SARS-CoV-2 variants of concern and spike protein mutational dynamics in a Swedish cohort during 2021, studied by Nanopore sequencingArticle Published on 2022-10-182022-11-15 Journal: Virology Journal [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] A222V analysed approach ARTIC Network assist bioinformatics can be used circulating variant Cohort COVID-19 COVID-19 pandemic Delta delta variant distribution genomic Health include less mapped Mutation mutations nanopore sequencing National occurred omicron Patient positive primer Protein public health public health measures Q677H S protein SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 variant sequence Sequencing sequencing method spike Spike protein Surveillance Swedish the S protein the SARS-CoV-2 the Spike Uppsala County variant variants variants of concern. variants of interest VoC whole-genome sequencing [DOI] 10.1186/s12985-022-01896-x PMC 바로가기
Detection of SARS-CoV-2 in a dog with hemorrhagic diarrheaArticle Published on 2022-10-122022-11-15 Journal: BMC veterinary research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome Affect African amino acid substitution analyzed Asymptomatic B.1.177 Bacterial Cell Ceuta characteristic circulation coronavirus COVID-19 detection diarrhea disease dog Dog COVID-19 excluded fecal gastrointestinal tract Genome Hemorrhagic Highland human SARS-CoV-2 human-to-animal transmission Ile402Val S protein substitution Infection Interaction intrinsic knowledge mapped microbial Microbiome MOST negative test Next-generation sequencing NGS North one health pandemic Pathogens pathology positive presenting RBD Receptor binding domain reported RT-PCR test S protein SARS-CoV-2 SARS-CoV-2 genome sequence Sequencing Spain Spanish suffered Terrier the S protein the spike protein USA variant viral loads viral variant virus West zoonosis. [DOI] 10.1186/s12917-022-03453-8 PMC 바로가기
Divergent SARS-CoV-2-specific T cell responses in intensive care unit workers following mRNA COVID-19 vaccinationArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome analyzed antibody CD4 CD4+ CD4+ T cells CD8 CD8+ CD8+ T cells Cellular immune response competent coronavirus COVID-19 COVID-19 vaccination develop dose elicited ELISPOT exhibited had no healthy individuals humoral ICU immune protection immune response individual individuals information intensive care intensive care unit workers lack maintain mRNA mRNA COVID-19 vaccines mRNA vaccine neutralizing antibody proportion Protein protein S reactive receiving reduction in SARS-CoV-2 SARS-CoV-2-specific T cell Seroconversion seronegative Specific T-cell response susceptibility T cell T cell response T cells T lymphocyte T-cell the S protein the SARS-CoV-2 the spike protein vaccination vaccination. viral infection Viral protein [DOI] 10.3389/fimmu.2022.942192 PMC 바로가기
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike proteinArticle Published on 2022-10-042022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome affected Antiviral assays coronavirus coronavirus disease epitope glycoprotein heptad repeat host cell HR2 include inhibit inhibitor interact interfere less membrane membrane fusion Modification monoclonal antibody Mutation N-terminal offer peptide Peptide Inhibitors peptide. peptides performed Protein Receptor binding domain Region related viruses S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Support target the S protein the SARS-CoV-2 the spike protein therapy Vaccine variants viral entry viral membrane viral spike virus infection [DOI] 10.1073/pnas.2210990119 PMC 바로가기
RBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challengeArticle Published on 2022-10-012022-11-15 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] amino acid change antibody B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.427 B.1.429 B.1.617.1 B.1.617.2 Beta Combination D614G mutation Delta disease severity domain E484K evaluated expressing Gamma greater highlight human-to-human transmission induce L452R Lineage lineages mice moderate mouse-adapted SARS-CoV-2 mRNA vaccine Multiple multiple mutations Mutation mutations N439K N501Y neutralization neutralized Neutralizing activity neutralizing antibody observation omicron other variant P.1 P681R pandemic PROTECT Protein pseudotyped pseudovirus reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants serum antibody T478K the S protein Transmissibility vaccination Vaccine variant variants virulent [DOI] 10.1016/j.trsl.2022.04.007 PMC 바로가기
Antiviral Immunoglobulins of Chicken Egg Yolk for Potential Prevention of SARS-CoV-2 InfectionArticle Published on 2022-09-262022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료제, [키워드] addition amplification analyzed anti-RBD antibody Antiviral antiviral strategy. assays Cell chicken clinical development cytokine domain Egg ELISA examined expression of SARS-CoV-2 Gene Expression golden hamster Host IgY immune immunization immunized immunoblot in vitro in vivo interval layer lung management monoclonal antibody neutralization capacity neutralized neutralizing antibody outbreak Outbreaks polyclonal Potential prevention purified qRT-PCR RBD SARS-CoV-2 SARS-COV-2 infection Syrian golden hamster target the S protein VERO-E6 Vero-E6 cell viability viral outbreak viral RBD Viral RNA virus virus variant viruses was measured yolk [DOI] 10.3390/v14102121 PMC 바로가기
Biophysical Modeling of SARS-CoV-2 Assembly: Genome Condensation and BuddingArticle Published on 2022-09-202022-11-16 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] assembly budding caused cellular condensation coronavirus 2 COVID-19 pandemic curtail de novo develop drug target envelope Genome genome condensation genomic RNA host cell identify Infectious virus Interaction intrinsic M protein mechanism membranes modeling molecular Mutation N protein oligomerization pathogen Protein protein intrinsic curvature. Research respiratory responsible resulting RNA SARS-CoV-2 spike structural protein structural proteins the S protein therapeutic target therapy Vaccines viral entry viral life cycle viral particle virus while [DOI] 10.3390/v14102089 PMC 바로가기
Model of the SARS-CoV-2 Virus for Development of a DNA-Modified, Surface-Enhanced Raman Spectroscopy Sensor with a Novel Hybrid Plasmonic Platform in Sandwich ModeArticle Published on 2022-09-192022-11-15 Journal: Biosensors [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome amplification amplifying Antigen approach aptasensor Combination complexes component Compound coronavirus coronavirus detect Developed development DNA domain high stability hybrid Infection Interaction investigated mode Model novel Particle platform Protein provided RBD S-protein Sandwich SARS-CoV-2 SARS-CoV-2 virus scattering sensitivity sensor Spectroscopy Structure Surface-enhanced Raman scattering (SERS). the S protein the SARS-CoV-2 the SARS-CoV-2 virus virion virus viruses Wuhan [DOI] 10.3390/bios12090768 PMC 바로가기
Structural- and Site-Specific N- Glycosylation Characterization of COVID-19 Virus Spike with StrucGPArticle Published on 2022-09-132022-11-15 Journal: Analytical Chemistry [Category] SARS, 치료기술, [키워드] addition Algorithm analyzed characterization COVID-19 COVID-19 virus glycan glycosylation Infection Mannose 6-phosphate mapped motif Previous studies previous study Protein residues SARS-CoV-2 Sequencing spike Structure structures Support the S protein trimer [DOI] 10.1021/acs.analchem.2c02265 PMC 바로가기
Variation of Proteolytic Cleavage Sites towards the N-Terminal End of the S2 Subunit of the Novel SARS-CoV-2 Omicron Sublineage BA.2.12.1Article Published on 2022-09-082022-11-16 Journal: Molecules [Category] SARS, 변종, [키워드] accompanied Activation amino acid substitution BA.2.12.1 binding cathepsin G Cell cleavage site cleaved complex COVID-19 digested End furin immune response Infection MHC modify neutrophil Neutrophil elastase Neutrophils novel omicron Omicron variant Pathogens peptide polybasic Prevalence priming protease Protein proteinase proteinase 3 S1/S2 S2 antigen S2 subunit SARS-CoV-2 SARS-CoV-2 variant secrete sequence serine protease serine proteases serine proteases. Site Support T cell activation the major histocompatibility the S protein the Spike TMPRSS2 viral entry [DOI] 10.3390/molecules27185817 PMC 바로가기