Rapid and universal detection of SARS-CoV-2 and influenza A virus using a reusable dual-channel optic fiber immunosensorArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 신종인플루엔자, 치료기술, [키워드] clinical sample colloidal gold Delta demonstrated detect dual-channel optic fiber immunosensor enzyme-linked immunosorbent Evanescent fiber H1N1 H3N2 H7N9 Infectious disease influenza A influenza A virus influenza A virus limit of detection linear mobile phase detection. much higher omicron optical pathogenic viruses platform presenting Rapid Real-time monitoring respond SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 pseudovirus sensitivity specificity Strains Surveillance TCID the epidemic the SARS-CoV-2 the spike protein variants viruses [DOI] 10.1002/jmv.28015 PMC 바로가기
Diffusion-Induced Ingress of Angiotensin-Converting Enzyme 2 into the Charge Conducting Path of a Pentacene Channel for Efficient Detection of SARS-CoV-2 in Saliva SamplesArticle Published on 2022-10-282022-11-15 Journal: ACS Sensors [Category] COVID19(2023년), SARS, 치료기술, [키워드] accelerate ACE2 angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) biosensor can be used channel charge Conducting correlation COVID-19 detection diagnostic test disease efficient false-negative field-effect transistor. gold standard growth handling highest integration Laboratory Large-scale testing less medium molecular Organic field-effect transistor path pathogen platform POC point-of-care Rapid receptor remote monitoring reported Saliva Sample SARS-CoV-2 sensitivity specimens Spread statistical analysis the disease the epidemic the SARS-CoV-2 virus the spike protein transfer Viral RNA viral titer virus [DOI] 10.1021/acssensors.2c01287 PMC 바로가기
Insertion/deletion hotspots in the Nsp2, Nsp3, S1, and ORF8 genes of SARS-related coronavirusesArticle Published on 2022-10-282022-11-16 Journal: BMC Ecology and Evolution [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome animal hosts base bases bat bat coronavirus benefit Characteristics classical complex coronavirus determine Frame Future Genome genomic region hotspot Human human SARS-CoV-2 human SARS-CoV-2 strain INDEL Indel hotspot indels insertion/deletion insertion/deletion (indel). mechanism Multiple sequence alignment Mutation N-terminal domain Neutral non-structural protein Occurrence offer ORF8 ORF8 gene pangolin Pangolin coronavirus (PCoV) Point mutation RaTG13 Region reported RNA sequence S1 domain SARS-CoV SARS-CoV-2 SARS-related coronavirus SARS-related coronaviruses severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) survival the spike protein viral evolution virus virus viruses [DOI] 10.1186/s12862-022-02078-7 PMC 바로가기
Comparative Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Variants in the Ferret ModelArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome Airborne transmission Analysis assessment Beta changes Comparative Contact coronavirus coronavirus 2 COVID-19 Critical Delta disease evaluate ferret ferrets genomic variant Heterologous highest histopathological homologous homologous or heterologous Human in vivo infection with SARS-CoV-2 inoculated lineages lowest Mild Model offered pandemic Particle pathogenicity provided Reinfection replicated Replication replication kinetics respiratory respiratory tract risk RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strains SARS-CoV-2 variant Spread Strains Surveillance the spike protein the United State Transmissibility Transmission transmitted upper respiratory tract USA-WA1/2020 variant Variant. variants virulence virus virus virus infection virus load WA1 while [DOI] 10.1128/mbio.02421-22 PMC 바로가기
Neutralizing SARS-CoV-2 Spike Antibodies against Omicron in Paired Samples after Two or Three Doses of mRNA VaccineArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] addition antibodies antibody Beta booster dose confounder COVID-19 death Delta demonstrated detect eliminated Hospitalization Immune escape mRNA mRNA vaccination mRNA vaccine neutralization neutralization activity Neutralizing neutralizing capacity Neutralizing titer omicron Omicron variant other variant protection provide reactive Sample SARS-CoV-2 SARS-CoV-2 antibody testing seroprevalence. Serum Neutralization significant increase significantly higher spike spike IgG tested the spike protein the vaccine unique utility Vaccine vaccine response variant variants of concern [DOI] 10.1128/spectrum.02046-22 PMC 바로가기
Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and ReplicationArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Alpha Altered Anti-viral Anti-viral therapy Antiviral assays biological molecules cathepsin L Cell cell entry cellular proteases cleaved designer serpin effective enzyme expressing facilitate furin furin. generate host cell protease implicated in vitro infection with SARS-CoV-2 inhibit inhibition inhibitor inhibitors inhibitory inhibitory activity loop membrane fusion Mutagenesis P681R predicted produced protease Protein purified rate constant reactive Recombinant protein S protein cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral replication SARS-CoV-2 virus serine 2 serine protease inhibitor SerpinB3 shown specificity suppress target the Spike the spike protein TMPRSS2 transmembrane variant Vero E6 cell [DOI] 10.3390/ijms232012522 PMC 바로가기
Enhanced antibody responses in fully vaccinated individuals against pan-SARS-CoV-2 variants following Omicron breakthrough infectionArticle Published on 2022-10-182022-11-15 Journal: Cell Reports Medicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome ancestral Antibody Response Breakthrough infection coronavirus Course COVID-19 infection creating cross-neutralization cytokine D614G dominant enhanced evade immune Immunity individual induce memory T cell mRNA mRNA vaccination mRNA vaccine neutralization Neutralizing activity neutralizing antibody Neutralizing antibody response Neutralizing antibody titer omicron Omicron BA.1 Omicron BA.2 producing PROTECT recovered patient respond SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants serum T cell T cell immune response the spike protein vaccinated individual vaccination variant variants of concern variants of concern. virus [DOI] 10.1016/j.xcrm.2022.100764 PMC 바로가기
Kinetics of Drug Molecule Interactions with a Newly Developed Nano-Gold-Modified Spike Protein Electrochemical Receptor SensorArticle Published on 2022-10-172022-11-15 Journal: Biosensors [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] amplification antiviral drug Chloroquine compounds Concentration correlated COVID-19 Detection sensitivity Developed docking drug drug target drugs electrochemical receptor biosensor exhibit Gln group Hydrogen bond Hydroxychloroquine Interaction investigated kinetic Kinetics limit of detection linear linkage allosterism molecule pandemic Protein provide receptor reported Research residue SARS-CoV-2 sensor Seven spike Spike protein spike protein. the SARS-CoV-2 the spike protein Treatment was used WHO World Health Organization [DOI] 10.3390/bios12100888 PMC 바로가기
Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airwaysArticle Published on 2022-10-152022-11-16 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] airway airways Analysis Beta calu-3 cells cathepsin-dependent Cell cleavage cultured cells Essential furin Gamma host proteases in vivo infect Infection isolate mice mouse-adapted SARS-CoV-2 multiple pathway murine omicron pathway recent reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants shown significantly the spike protein TMPRSS2 variant [DOI] 10.1038/s41467-022-33911-8 PMC 바로가기
Antioxidant, Anti-inflammatory, and Immunomodulatory Roles of Nonvitamin Antioxidants in Anti-SARS-CoV-2 TherapyArticle Published on 2022-10-132022-11-15 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 바이오마커, 치료제, [키워드] ACE2 receptor Activation activities alleviate Alleviating alveolar antioxidant antiviral role conformational change COVID-19 Cytokine storm Dipeptidyl peptidase 4 Direct dosage Endothelium favor furin Helicase host receptor hyperinflammation Illness severity immunogenic Inflammatory Inflammatory responses influences membranes Organ failure oxidative stress Papain-like protease pathology pathway protease reactive oxygen specy Receptor binding domain Replication risk RNA-dependent RNA polymerase role serine 2 the spike protein transmembrane vicious cycle viral spike protein [DOI] 10.1021/acs.jmedchem.2c01134 PMC 바로가기