Characterizing the Spatiotemporal Heterogeneity of the COVID-19 Vaccination LandscapeArticle Published on 2022-09-282022-11-16 Journal: American journal of epidemiology [Category] SARS, 변종, [키워드] acute respiratory syndrome center Cluster Control coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 COVID-19 vaccination Critical data accuracy discrepancy effort exhibit foci growth heterogeneity IMPROVE landscape outcome prevention rising SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome coronavirus 2 spatiotemporal Spatiotemporal analysis statistically the SARS-CoV-2 the United State The United States These data Transmission United States vaccination variant widespread [DOI] 10.1093/aje/kwac080 PMC 바로가기
Comparison of Intracellular Transcriptional Response of NHBE Cells to Infection with SARS-CoV-2 Washington and New York StrainsArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] 24 hour acute respiratory syndrome affected analyzed bioinformatics caused Cell cellular coronavirus COVID-19 D614G mutation Data mining death DEGs different time point differentially expressed gene dysregulated Effect epithelial experiment Gene ontology Genome global pandemic GO terms Host host cells host response Host transcriptional response host-virus hpi identify immune IMPROVE include Infection infections inhibited Intracellular mechanism Mutation New York NHBE pathway Pathways Patient positive Post-infection reported response resulting RNA sequencing data SARS-CoV-2 SARS-CoV-2 isolate severe disease shown Signaling signaling pathways similarity stability strain Strains These data transcript translation viral isolate viral spike protein Virology virus virus replication Washington while Wuhan, China [DOI] 10.3389/fcimb.2022.1009328 PMC 바로가기
Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivationArticle Published on 2022-09-142022-11-16 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 유전자 메커니즘, [키워드] activated Activation acute respiratory syndrome Adenovirus aggravate Aggravated alleviate complement Complement pathway contribute coronavirus Coronaviruses expressing highly pathogenic human coronaviruses Hyperactivation in vitro in vivo Inflammation inflammatory lung injury Inflammatory response Interaction lectin pathway Lung injury MASP-2 mechanism MERS-CoV mice N protein Pathogenesis pathogenic coronavirus Pneumonia respiratory syndrome coronavirus resulting SARS-CoV SARS-CoV-2 SARS-CoV-2-infected patients serine protease significantly suggested the N protein Therapeutic approach These data [DOI] 10.1038/s41392-022-01133-5 PMC 바로가기
Detection of Higher Cycle Threshold Values in Culturable SARS-CoV-2 Omicron BA.1 Sublineage Compared with Pre-Omicron Variant Specimens – San Francisco Bay Area, California, July 2021-March 2022Article Published on 2022-09-092022-11-15 Journal: Morbidity and Mortality Weekly Report [Category] SARS, 변종, 치료기술, [키워드] Analysis Area B.1.1.529 cause CDC Cohort collected COVID-19 Culture cycle cycle threshold demonstrated detection generate Guidance in viral Infection infections Infectious virus marker nasal omicron participant positive public health reliability remains uncertain Research RNA RT-PCR San Francisco Bay SARS-CoV-2 SARS-CoV-2 test SARS-CoV-2 variant SARS-CoV-2 variants specimen Supporting These data unlikely value variant variant of SARS-CoV-2 Viral RNA virus were used [DOI] 10.15585/mmwr.mm7136a3 PMC 바로가기
Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactionsArticle Published on 2022-09-082022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] accompanied Activation animal model bioinformatics cells characterized chemokine COVID-19 COVID-19 patients E protein expression Extracellular matrix immune immune response immunological immunomodulatory property Inflammation Interaction intrinsic kinases lipid metabolism Loss of Smell machine metabolic molecular multifunctional olfactory Protein proteome proteomic proteomics receptor reveal SARS-CoV-2 secretion Signaling Smell structural protein survival Symptom TGF-beta signaling the SARS-CoV-2 These data trajectory transcriptomics tyrosine virion widespread [DOI] 10.3389/fimmu.2022.866564 PMC 바로가기
Hydroxypropyl-beta-cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication and virus-induced inflammatory cytokines하이드록시프로필-베타-사이클로덱스트린(HP-BCD)은 SARS-CoV-2 복제 및 바이러스 유발 염증성 사이토카인을 억제합니다Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] accompanied ACE2 Affect affected Alter antiviral activity Beta Beta-cyclodextrin Calu Calu-3 Cell cell line cell lines cholesterol COVID-19 COVID-19 disease cyclodextrin Cytokines cytopathic effects demonstrated disease drug Drug repurposing evidenced excipient experimental models expression Human Hyperinflammatory syndrome immunomodulatory effect in vitro in vivo Inflammation Inflammatory cytokine Inflammatory response inhibit inhibited inhibiting investigated microbial products mitigate Monocytes Particles pathophysiology primary human cells Proinflammatory cytokine proinflammatory cytokines protein levels reducing reduction in Replication replication complexes required Respiratory system safety profile SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV2 selected selective significantly systemic manifestations the disease therapeutic therapeutic agent therapeutic strategy These data treating Treatment viral cytopathic effect virus virus replication virus RNA [DOI] 10.1016/j.antiviral.2022.105373 PMC 바로가기 [Article Type] Article
Longitudinal dynamics of SARS-CoV-2 anti-receptor binding domain IgG antibodies in a wide population of health care workers after BNT162b2 vaccinationArticle Published on 2022-09-012022-11-15 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Analysis analyzed Anti-RBD antibody Anti-RBD IgG antibody binding antibody binding domain BNT162b2 BNT162b2 vaccine coronavirus decrease domain doses female female participant HCWs Health care Health care worker health care workers highest highlight Humoral response IgG antibody IgG level immune response Immunoglobulin longitudinal male quantitative assay RBD SARS-CoV-2 second dose Sex significant difference spike glycoprotein Support the RBD the S1 subunit the spike protein the vaccine These data vaccination Vaccines were measured [DOI] 10.1016/j.ijid.2022.05.061 PMC 바로가기
Commentary on CDC data showing an increased risk for pediatric diabetes with COVID-19 infectionArticle Published on 2022-09-012022-11-16 Journal: Journal of diabetes [Category] SARS, 변종, [키워드] body mass index CDC center children Control COVID‐19 infection diabete diabetes Health incidence increased risk Infection Interpretation lack pediatric prevention question report significant increase social determinant These data viral variant Weekly with COVID-19 [DOI] 10.1111/1753-0407.13311 PMC 바로가기
Rational design of AAVrh10-vectored ACE2 functional domain to broadly block the cell entry of SARS-CoV-2 variantsSARS-CoV-2 변이체의 세포 진입을 광범위하게 차단하기 위한 AAVrh10 벡터화 ACE2 기능 도메인의 합리적인 설계Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 ortholog ACE2 orthologs adeno-associated virus Adeno-associated virus (AAV) vector amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 breadth Candidates cell entry comprehensive analysis COVID-19 COVID-19 vaccine domain Effectiveness Ex vivo exhibited fragment of functional higher affinity human ACE2 in silico in vitro Infection Interaction neutralizing antibody Protein RBD Receptor binding domain sACE2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants serotype the RBD therapeutic strategy therapy These data tissue tropism variant variants virus was performed weakened [DOI] 10.1016/j.antiviral.2022.105383 PMC 바로가기 [Article Type] Article
Preserved recognition of Omicron spike following COVID-19 messenger RNA vaccination in pregnancy임신 중 COVID-19 메신저 RNA 백신 접종 후 오미크론 스파이크의 보존된 인식Article Published on 2022-09-012022-09-11 Journal: American journal of obstetrics and gynecology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] administration analyzed antibodies antibody attenuate binding center Complete Control COVID-19 COVID-19 vaccine COVID-19 vaccines disease disease control disease course disease severity during pregnancy Efficacy Evolution of SARS-CoV-2 Fc receptor Fc receptors Fcγ receptor full dose regimen Immunoglobulin immunoglobulin M Infection Luminex assay Messenger RNA Moderna mRNA mRNA vaccine mRNA-1273 neutralization Neutralizing activity Neutralizing antibodies obstetrics omicron Omicron variant organization Pfizer/BioNTech Pregnancy pregnant women preserved prevention PROTECT raised receiving receptor Receptor binding Receptor binding domain reduce reduced remained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe disease Spike-specific antibody These data vaccinated individuals vaccination Vaccine vaccine efficacy vaccine-induced antibodies vaccine-induced antibody Vaccine-induced immunity variant variants variants of concern [DOI] 10.1016/j.ajog.2022.04.009 PMC 바로가기 [Article Type] Article