COVID-19 mortality and excess mortality among working-age residents in California, USA, by occupational sector: a longitudinal cohort analysis of mortality surveillance dataArticle Published on 2022-09-012022-11-16 Journal: The Lancet. Public Health [Category] SARS, 변종, [키워드] 95% prediction interval Abuse aging Analysis anticipated average B.1.617.2 calculated causes cohort analysis Coverage COVID-19 COVID-19 mortality COVID-19 pandemic death deaths Department died disparity driven by drug foundation highest Infection infections longitudinal cohort study Mortality nine occur occurred pandemic PROTECT provided Public Region reported risk SARS-COV-2 infection SARS-CoV-2 variant Science stratified surveillance data threat USA vaccination Vaccine vaccine availability variant variants widespread worker [DOI] 10.1016/S2468-2667(22)00191-8 PMC 바로가기
A comprehensive review of artificial intelligence and network based approaches to drug repurposing in Covid-19Review Published on 2022-09-012022-10-04 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 변종, 신약개발, 임상, 치료제, [키워드] AI on networks Analysis approach attrition rates Conventional de novo deep deep learning diffusion Diseases drug Drug discovery Drug repurposing effective Interaction limitation machine machine learning mitigate network network analysis Network diffusion Network proximity platform previous study recommendation required risk shown threat variety [DOI] 10.1016/j.biopha.2022.113350 PMC 바로가기 [Article Type] Review
On virus and nanomaterials – Lessons learned from the innate immune system – ACE activation in the invertebrate model Enchytraeus crypticus바이러스 및 나노물질에 관하여 - 선천적 면역계에서 배운 교훈 - 무척추동물 모델 Enchytraeus crypticus에서 ACE 활성화Article Published on 2022-08-152022-09-11 Journal: Journal of hazardous materials [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE ACE gene ACE2 Activation angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 caused Cell Community Conserved mechanisms Corona Corona virus COVID-19 current database develop down-regulation enzyme experiment expression fold functional immune immune system Inflammatory Innate innate immune response innate immune system invertebrate invertebrates knowledge lesson mechanism Nanomaterial nanomaterials Other receptor Research respiratory responses SARS-CoV-2 Severe acute respiratory syndrome Spike proteins stress condition stress conditions stress response Support the spike protein therapy threat Threats Total transfer triggering vertebrates virus [DOI] 10.1016/j.jhazmat.2022.129173 PMC 바로가기 [Article Type] Article
Attractive targeted sugar bait phase III trials in Kenya, Mali, and Zambia케냐, 말리, 잠비아에서 매력적인 표적 설탕 미끼 3상 시험Clinical Trial Published on 2022-08-092022-09-11 Journal: Trials [Category] 말라리아, 임상, 치료제, [키워드] adaptive ARMS Attractive targeted sugar bait children Cluster cluster separation Cluster-randomized controlled trial Clusters Cohort Contamination Controlled trial core covariate covariates COVID-19 pandemic detect determine dinotefuran Effects External validity Follow-up Imbalance IMPROVE incidence include insecticidal insecticide interim analysis internal validity Intervention Kenya kill Longevity malaria morbidity mosquito density Open-label open-label design phase III trial Prevalence Primary outcome Primary outcomes randomization receive reduce reduction in reductions in Restricted resulting risk Sample size secondary outcome strength Structure sugar threat Transmission transmission pattern Trial Two-arm Validity Variation vector vector control vectors [DOI] 10.1186/s13063-022-06555-8 PMC 바로가기 [Article Type] Clinical Trial
Comparing the Cytokine Storms of COVID-19 and Pandemic InfluenzaCOVID-19와 유행성 인플루엔자의 사이토카인 폭풍 비교Article Published on 2022-08-012022-09-11 Journal: Journal of interferon & cytokine research : the of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration caused Characteristics coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine cytokine profile Cytokine storm Cytokine storms Cytokines death determine diagnostic disease driving emerging respiratory viruses Factor flu Health help homology immune immune mechanism immune signature immunopathological immunopathology Immunotherapy increasingly Infection infections Influenza less Manifestations morbidity Outbreaks over pandemic pathogenic mechanisms Perspective Protective respiratory infections respiratory virus respiratory viruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe infection severe respiratory infection similarities similarity storm target targets threat translational unique [DOI] 10.1089/jir.2022.0029 PMC 바로가기 [Article Type] Article
COVID-19 vaccination in patients with long QT syndromeReview article Published on 2022-08-012022-10-05 Journal: Heart Rhythm O2 [Category] 변종, 유전자 메커니즘, [키워드] arrhythmia booster dose Complication conditions COVID-19 COVID-19 vaccination eligible febrile Inherited cardiac arrhythmias life-threatening Long QT syndrome myocarditis orthostatic Patient QT interval QT prolongation reduce risk SARS-CoV-2 susceptible syndrome Tachycardia threat vaccination Vaccinations variant [DOI] 10.1016/j.hroo.2022.07.011 [Article Type] Review article
The impact of non-pharmaceutical interventions on COVID-19 cases in South Australia and Victoria사우스 오스트레일리아와 빅토리아의 COVID-19 사례에 대한 비약물적 개입의 영향Article Published on 2022-08-012022-09-11 Journal: Australian and New Zealand journal of public healt [Category] COVID19(2023년), SARS, 변종, [키워드] 95%CI border control Coverage COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic death decrease disease disease control Effectiveness First wave implementation incidence incidence rate Infectious diseases Intervention interventions lockdown management Mask NPI NPIs Pandemics Poisson regression Poisson regression models provide public health rate ratio Society South thought threat Threats vaccination variants variants of concern Victoria [DOI] 10.1111/1753-6405.13249 PMC 바로가기 [Article Type] Article
Preclinical immunogenicity and efficacy of a candidate COVID-19 vaccine based on a vesicular stomatitis virus-SARS-CoV-2 chimera수포성 구내염 바이러스-SARS-CoV-2 키메라 기반 코로나19 후보 백신의 전임상 면역원성과 효능Article Published on 2022-08-012022-09-12 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome administration AIDS approach authority candidate vaccine chimeric coding sequence coronavirus coronavirus disease cotton Cotton rat COVID-19 COVID-19 vaccine Department develop development dose Ebola virus Efficacy evaluated glycoprotein hamster hamsters Immunity immunogenic immunogenicity Inc Inc. initiative injection intramuscular lung mucosal Mucosal vaccination nasal nasal tissue New York Part Preclinical PROTECT reduce reduced replacing Research respond SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 vaccine Sharp significantly single vaccine spike stomatitis supported Syrian hamster the SARS-CoV-2 the vaccine threat tissues Transmission USA vaccination Vaccine vaccine candidate vesicular stomatitis vesicular stomatitis virus virus virus load VSV weight loss [DOI] 10.1016/j.ebiom.2022.104203 PMC 바로가기 [Article Type] Article
The genetic and evolutionary determinants of COVID-19 susceptibilityCOVID-19 감수성의 유전적 및 진화적 결정 요인Review Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] admixture applied approach archaic humans cellular contribute Course COVID-19 COVID-19 illness COVID-19 susceptibility determinant disease disease susceptibility Diseases Ethnic groups event explain facilitated Factor Genetic Genetic predisposition Human genetics humans immunological immunological mechanism individual Infection infectious agents Infectious disease Infectious diseases knowledge molecular outbreak outcome Pandemics Pathogens Perspective recent finding recent findings reported SARS-COV-2 infection severity severity of COVID-19 susceptibility threat Threats Variability [DOI] 10.1038/s41431-022-01141-7 PMC 바로가기 [Article Type] Review
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies마비 관련 키나아제는 SARS-CoV-2 감염에 필요하며 항바이러스 전략의 세포 표적입니다Article Published on 2022-08-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 치료제, [키워드] AAK1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral strategy approach approaches approved caused cellular combination treatment coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated drugs epithelial cells Erlotinib experiment expression functional GAK Genetic global health Health Host-targeted antivirals human lung human lung epithelial cells implication in vitro inhibited kinase kinase inhibitors kinases late stage life cycle multiple RNA viruses Numb Numb-associated kinases other coronaviruses pandemic pharmacological principle probe reported required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro SARS-CoV-2 life cycle SARS-CoV-2 pseudovirus severe acute respiratory syndrome Coronavirus siRNA small molecule STK16 sunitinib suppressed synergistic synergistic effect target the SARS-CoV-2 threat treat viral entry wild type [DOI] 10.1016/j.antiviral.2022.105367 PMC 바로가기 [Article Type] Article