Inhibition of IRAK4 dysregulates SARS-CoV-2 spike protein-induced macrophage inflammatory and glycolytic reprogrammingIRAK4의 억제는 SARS-CoV-2 스파이크 단백질 유도 대식세포 염증 및 해당과정 재프로그래밍을 조절하지 못함Article Published on 2022-05-192022-09-11 Journal: Cellular and Molecular Life Sciences [Category] Coronavirus, COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 activate AKT baseline blockade CCL2 cells citrate counteract Critical dysregulated ERK expression Glycolysis human SARS-CoV-2 Hyperactivation IL-6 IL-8 impair independent Inflammatory Inflammatory marker inflammatory markers inhibition inhibitor Innate immunity irak4 IRAK4 inhibitor IRF5 IRF7 knockdown Lactate LDHA Macrophage macrophages metabolic activity mitochondrial Mitochondrial oxidative phosphorylation molecular mechanism monokines murine models NF-κB NF-κB activation oxidative oxidative phosphorylation phenotype Phosphorylation promoted Protein reduction response responsible reversal SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein severe COVID-19 patient severe COVID-19 patients shown Signaling siRNA spike Spike protein succinate suppression Therapeutic strategies therapy TLR TLR-mediated TLR2 TLR7 TLRs TNFα treated Treatment triggered without affecting [DOI] 10.1007/s00018-022-04329-8 PMC 바로가기 [Article Type] Article
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infectionTLR2 및 TLR7은 SARS-CoV-2 감염에 대한 뚜렷한 면역병리학적 및 항바이러스 형질세포양 수지상 세포 반응을 매개합니다Article Published on 2022-05-162022-09-12 Journal: The EMBO Journal [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Antiviral antiviral interferon circulating COVID-19 patient Critical CXCL10 cytokine de novo decreased expression dendritic cell disease severity driving engage epithelial cell identify IFNs IFNα IL-6 IL-8 immunopathological in vitro Inflammatory Inflammatory response innate immune innate immune pathways innate immune sensing interferon response mitigate molecular Neuropilin-1 pathway pDC pDC. pDCs plasmacytoid dendritic cell potential therapeutic target PROTECT receptor response responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe COVID-19 Signaling symptom onset systemic inflammatory TLR2 TLR7 Treatment type I understanding Via virus [DOI] 10.15252/embj.2021109622 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 InterventionsArticle Published on 2022-05-082023-07-09 Journal: Viruses [Category] COVID19(2023년), [키워드] CXCL8 envelop (E) protein. SARS-CoV-2 TLR2 [DOI] 10.3390/v14050999 PMC 바로가기
Recognition of Immune Cell Markers of COVID-19 Severity with Machine Learning Methods기계 학습 방법을 통한 COVID-19 심각도의 면역 세포 마커 인식Article Published on 2022-04-282022-09-11 Journal: BioMed Research International [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, [키워드] Algorithms analyzed B cell best Biomarker Biomarkers CD4 CD8 Cell cell type classifiers COVID-19 COVID-19 disease COVID-19 disease severity CX3CR1 Decision tree determine disease Disease progression disease severity feature filtered Gene expression analysis gene expression profile Host IL1B Immune cell immune cells immune response Immunological response immunological responses Inflammatory involved ITK KEGG pathway machine learning molecular mechanism molecular mechanisms monocyte Mortality NK cell Numerous PRDM1 random Random forest Recognition Regulation resulting SARS-COV-2 infection single-cell these cell These cells TLR2 [DOI] 10.1155/2022/6089242 PMC 바로가기 [Article Type] Article
The serum of COVID-19 asymptomatic patients up-regulates proteins related to endothelial dysfunction and viral response in circulating angiogenic cells ex-vivoCOVID-19 무증상 환자의 혈청은 생체 외 순환하는 혈관 신생 세포에서 내피 기능 장애 및 바이러스 반응과 관련된 단백질을 상향 조절합니다Article Published on 2022-04-092022-09-12 Journal: Molecular Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] Activation acute respiratory syndrome applied approach Asymptomatic Asymptomatic COVID-19 asymptomatic individual Asymptomatic individuals asymptomatic patient caused Cell cellular change circulating Circulating angiogenic cells Coagulation coronavirus correlated COVID-19 COVID-19 negative critical COVID-19 patients death Donor donors endothelial Endothelial dysfunction Endothelial progenitor cells evaluated Ex vivo Factor highest ICAM-1 identify IgG immune response incubated individuals Infection infective Inflammatory Inflammatory response inhibitor initial machine learning algorithm marker pathway PCR platform positive potential long-term sequelae promote promoted Protein protein level proteomics provoke Quantitative responsible SARS-CoV-2 SARS-COV-2 infection serum significantly Stage Symptoms Thromboembolic event TLR2 transmissions treated triggered understanding up-regulate up-regulated Vascular Vascular damage viral infection virus virus entry while [DOI] 10.1186/s10020-022-00465-w PMC 바로가기 [Article Type] Article
Does SARS-CoV-2 affect neurodegenerative disorders? TLR2, a potential receptor for SARS-CoV-2 in the CNS Reviews Published on 2022-04-082022-10-05 Journal: Experimental & Molecular Medicine [Category] COVID19(2023년), SARS, 바이오마커, [키워드] accumulating ACE2 ACE2 expression addition Affect Alzheimer’s disease binding caused Central nervous system CNS component components coronavirus COVID-19 Critical disease highlight identify infected patients Infection infiltration innate immune Interaction Lungs microbial neurodegenerative Neurological symptom pandemic Parkinson’s disease Pathogenesis pathogenic mechanism pathology patients Protein receptor recognize Respiratory system resulting SARS-CoV-2 SARS-COV-2 infection seeking shown therapy TLR2 unlikely viral entry virus [DOI] 10.1038/s12276-022-00755-7 [Article Type] Reviews
Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposingSARS-COV-2 감염 및 약물 용도에 영향을 미치는 기능, 경로 및 조절제를 강조하는 숙주 게놈 바이오 마커의 계산 식별Article Published on 2022-03-112022-08-31 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, 신약개발, 치료제, [키워드] 3CL Analysis analyzed binding affinities Biomarker candidate drugs Computational biology and bioinformatics control sample COVID-19 CXCL2 daclatasvir DEGs differentially expressed gene docking drug Drug discovery drug target drugs Economy effective enrichment analysis FDA approved Drugs function functional functions genomic GUCY1A2 highlighting Host hub-genes identify IGF2 independent indicate infections Interaction investigated IRF7 Ivermectin KEGG pathway KLF6 life miRNA miRNAs molecular docking analysis NEDD9 network analysis PAG1 pandemic pathway Pathways performed PPI Protein Protein–protein interaction Proteins Radotinib Rapamycin receptor receptor protein receptor proteins receptors reduced RNA sequence SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Seven signaling pathway signaling pathways significantly SNRPD2 stability Stat1 Systems biology tacrolimus the SARS-CoV-2 Thiostrepton TLR2 transcriptomics Treatment USP53 vaccination variants of SARS-CoV-2 ZFP36 [DOI] 10.1038/s41598-022-08073-8 PMC 바로가기 [Article Type] Article
Novel Synthetic Lipopeptides as Potential Mucosal Adjuvants Enhanced SARS-CoV-2 rRBD-Induced Immune ResponseSARS-CoV-2 rRBD 유도 면역 반응을 향상시키는 잠재적 점막 보조제로서의 새로운 합성 리포펩티드Article Published on 2022-03-092022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] activity adjuvant adjuvants Affect agonist agonists Bacterial BALF candidate vaccine charged residue COVID-19 vaccine CSK cytotoxicity Effect enhanced evaluated exhibited Figuring IgA IgG immune response immunized in vitro induce investigated lipopeptide lipoprotein mimicking mucosal N-terminal nasal novel OVA peptide Potential promote RBD residue response rRBD SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 rRBD sequence sera serum significantly increased significantly lower Structure Structure-activity relationship suggested Support support vector machine SVM synthetic the SARS-CoV-2 TLR2 Vaccine vaccine adjuvant [DOI] 10.3389/fimmu.2022.833418 PMC 바로가기 [Article Type] Article
Innate immune response analysis in COVID-19 and kawasaki disease reveals MIS-C predictorsCOVID-19 및 가와사키병의 타고난 면역 반응 분석은 MIS-C 예측 인자를 밝힙니다Article Published on 2022-03-012022-09-11 Journal: Journal of the Formosan Medical Association = Taiw [Category] SARS, 변종, 치료기술, [키워드] acute SARS-CoV-2 infection Adults analyses Analysis ArrayExpress association Blood blood cell Blood cells CASP1 CD14 CD36 children Cohort correlated COVID-19 COVID-19 diagnosis COVID-19 severity dataset determine disease downloaded dysregulated dysregulation enriched pathway enriched pathways expression level FCGR2A gene expression signature genetic polymorphisms HLA-DOB IFI16 IFNAR1 immune dysregulation immune response immune responses increased expression Inflammatory Innate innate immune innate immune gene innate immune genes innate immune response Innate immunity Interaction interactions irak4 IRF3 Kawasaki disease MIS-C moderate Multisystem inflammatory syndrome network network analysis NLRP3 pathway Patient PELI1 polymorphism predict predictor predisposition Pycard reveal SARS-CoV-2 infections severe COVID-19 severity STAT3 STING susceptibility syndrome TLR2 TLR7 TLR8 Transcriptome transcriptome datasets transcriptomes variant variants was used with COVID-19 [DOI] 10.1016/j.jfma.2021.06.009 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like propertiesSARS-CoV-2 스파이크 S1 소단위체는 신경염증, 소교세포 및 행동병 반응을 유도합니다: PAMP 유사 특성의 증거Article Published on 2022-02-012022-09-11 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] activated Activation Anxiety avoidance Brain brain region brain regions CAGE CD11b CD200R1 cells characterized CNS cognitive CXCL1 cytokine signaling demonstrated Depression Direct direct viral infection Evidence evidence of examined function Gene Expression GFAp HEK293 HEK293 cells HMGB1 Hypothesis IFNγ IL-10 IL-1β IL-2 IL-6 IL1B in vitro include independent independent of induce Infection Inflammatory injected male mechanism MHCII microglia microglial modulated Neuroinflammation neurological Neuropsychiatric NLRP3 PAMP PAMPs pathogen pathogen-associated molecular Pattern recognition pattern recognition receptor Protein protein level protein levels receptor signaling reduced S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein Sickness Sickness behavior spike Spike protein structural protein structural proteins Symptom the S1 subunit the SARS-CoV-2 TLR TLR. TLR2 TLR4 TNF transgenic Treatment vehicle viral infection [DOI] 10.1016/j.bbi.2021.12.007 PMC 바로가기 [Article Type] Article