SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in miceArticle Published on 2023-02-172024-09-05 Journal: Cell Reports [Category] update2024, [키워드] Cognitive dysfunction Genetic variant Long COVID microgliosis Neuroinflammation post-COVID syndrome SARS-CoV-2 spike protein synapse loss synaptic pruning TLR4 [DOI] 10.1016/j.celrep.2023.112189 PMC 바로가기 [Article Type] Article
Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathwayArticle Published on 2023-01-302022-11-16 Journal: Journal of ethnopharmacology [Category] 신종인플루엔자, 치료기술, [키워드] acute lung injury analyzed Anti-inflammation Apoptosis approved attenuate BALF Bcl-xL caspase Cell changes China confocal microscope coronavirus COVID-19 declined downstream drug Effect expression fatal complication flow cytometry food Granule H1N1 influenza histological histopathological IL-1β IL-6 immunofluorescence Infectious disease Influenza virus inhibited injection intrinsic investigated Jinhua Qinggan granules LPS lung Lung injury Lungs material mechanism mice Mild mitochondrial apoptotic pathway moderate morbidity and mortality MPO neutrophil Neutrophil apoptosis novel coronavirus disease Nuclear factor kappa-B nuclei p65 pathway pharmacological positive proportion Protein protein concentration protein expression pulmonary inflammation receptor reduced Respiratory disease Respiratory virus infection Signaling signaling pathway significantly staining survival survival rate TLR4 TNF-α toll-like receptor 4 treated Treatment were assessed were measured [DOI] 10.1016/j.jep.2022.115763 PMC 바로가기
Jacareubin inhibits TLR4-induced lung inflammatory response caused by the RBD domain of SARS-CoV-2 Spike proteinArticle Published on 2022-12-012023-07-10 Journal: Pharmacological Reports [Category] COVID19(2023년), [키워드] coronavirus Lung inflammation RBD Spike protein TLR4 [DOI] 10.1007/s43440-022-00398-5 PMC 바로가기
Evidence for Interplay Between the Renin-Angiotensin System and Toll-Like Receptor 4 Signaling Pathways in the Induction of Virus-Induced Acute Lung InjuryArticle Published on 2022-12-012023-07-10 Journal: Journal of interferon & cytokine research : the of [Category] COVID19(2023년), [키워드] ACE2 ALI angiotensin Inflammation macrophages RAS S protein SARS-CoV2 TLR4 [DOI] 10.1089/jir.2022.0081
The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to OmicronArticle Published on 2022-10-062022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 100% conserved Analysis Antigen Beta caused CD4 CD4+ CD8 CD8+ T cell clade clades composed confirmed cases conserved COVID-19 cross-protective deaths Delta epitope Epitopes Epsilon Eta Gamma Genome genomes GISAID greater highly antigenic HLA binding hydrophobic IFN-γ IL-10 IL-12 IL-2 IL-6 immune response immune responses immunoinformatics in silico approaches in vivo Lambda long-lasting majority memory Metadata molecular docking Mortality Mutation non-toxic offer omicron ORF ORF1ab ORF8 proteins peptide performed promoted Protein reduced Reinfection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants secretion severity Strains suffered T cell epitope TGF-β Th1 the Spike the vaccine TLR4 Vaccine variant variants virus virus transmission WHO Wuhan [DOI] 10.1038/s41598-022-21207-2 PMC 바로가기
Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike proteinArticle Published on 2022-09-122022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] activate blocking calprotectin circulating contribute COVID-19 Cytokine storm Delta Dok3 downstream dysregulated immune response effective elevated hallmark Increased JAK2 mechanism neutrophil Neutrophils omicron Prevent Protein recruit S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein severe COVID-19 severe COVID-19 manifestation Signaling STAT3 susceptible patients target therapy TLR4 variant variants [DOI] 10.3389/fimmu.2022.996637 PMC 바로가기
The Th1/Tfh-like biased responses elicited by the rASP-1 innate adjuvant are dependent on TRIF and Type I IFN receptor pathwaysArticle Published on 2022-09-022023-06-14 Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자, [키워드] conventional DCs influenza vaccine innate adjuvant rASP-1. RNA-Seq TLR4 TRIF type I interferon receptor [DOI] 10.3389/fimmu.2022.961094 PMC 바로가기
mTOR regulation of metabolism limits LPS-induced monocyte inflammatory and procoagulant responses Research Published on 2022-08-262022-10-05 Journal: Communications Biology [Category] 바이오마커, 진단, [키워드] activate Analysis cardiovascular disease catalytic Coagulopathy expression gene product IL-1β IL-6 immune cell type Inflammatory Inflammatory response limit LPS mechanism metabolism monocyte Monocytes mTOR inhibitor NAD+ pathway polyfunctional responses primary human monocyte pro-inflammatory pro-inflammatory cytokine procoagulant Regulation response risk Support tested tissue TLR4 transcriptional activity transcriptional response Treatment with HIV [DOI] 10.1038/s42003-022-03804-z [Article Type] Research
Identifying potential pharmacological targets and mechanisms of vitamin D for hepatocellular carcinoma and COVID-19Article Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, 진단, 치료제, [키워드] ACTA1 aggressiveness ALB analyses Analysis analyzed Anti-inflammatory anti-inflammatory action Antiviral effect binding activity bioinformatics Biological functions chemokine Coronavirus disease 2019 COVID-19 cytokine production digestive system Effect effective enrichment analysis epithelial evaluate HCC HCC patient HCC patients help hepatocellular Hepatocellular carcinoma HMOX1 identifying immune response immunomodulatory involved malignancy mechanism molecular molecular docking molecular mechanism network pharmacology pandemic performed pharmacological target poor prognosis Predictive Prognosis prognostic public health RBP4 Regulation risk Seven signaling pathway target gene Target genes therapeutic effect TLR4 TTR Vitamin D with COVID-19 [DOI] 10.3389/fimmu.2022.985781 PMC 바로가기