TLR8 – Page 2 – Communicable Diseases Research

Role of toll-like receptor 7/8 pathways in regulation of interferon response and inflammatory mediators during SARS-CoV2 infection and potential therapeutic options

Article

Published on 2021-06-102023-06-16
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS,

[키워드] CD14, cluster of differentiation 14 COVID-19 ELK-1, ETS like gene 1 tyrosine kinase oncogene IκBα, I kappaB alpha IKK, inhibitor of nuclear factor kappa B kinase IL-1, interleukin 1 IL-1β IL-12, interleukin 12 IL-6 IRAK, interleukin 1 receptor associated kinase 1 JNK1, JUN N-terminal kinase JUN, jun oncogene LBP, lipopolysaccharide binding protein MD-2, myeloid differentiation protein 2 MEKK1, MAPK/ERK kinase kinase 1 MKK, mitogen activated protein kinase MYD88, Myeloid Differentiation primary response protein 88 NFκB, nuclear factor kappaB NIK, NF-kappa-beta inducing kinase PKR, protein kinase R PPAR, peroxisome proliferator activated receptor alpha SARS-CoV2 SITPEC or ECSIT, ECSIT signaling integrator ST-2, growth stimulation expressed gene 2 or interleukin 1 receptor like 1 (IL1RL1) TAB, TGFβ activated kinase (MAP3K7) binding protein TAK1, TGFβ activated kinase 1 TIRAP, ‘TIR’ domain containing adaptor protein TLR, Toll like Receptor TLR7 TLR7/8 agonists TLR8 TNFα, Tumor necrosis factor alpha TOLLIP, toll interacting protein TRAF, TNF receptor associated factor type I interferons
[DOI] 10.1016/j.biopha.2021.111794 PMC 바로가기 [Article Type] Article

Dysregulation of Pulmonary Responses in Severe COVID-19

심각한 COVID-19에서 폐 반응의 조절 장애

Communication

Published on 2021-05-212022-09-01
Journal: Viruses [Category] SARS, 바이오마커, 진단,

[키워드] B cells BALF Bronchoalveolar lavage fluid Cell cells contribute coronavirus disease Coronavirus disease 2019 COVID-19 dataset epithelial cell epithelial cells expressing HAS2 high mortality Hyaluronan IFN-I IFNA1 IgA IgA-expressing lower expression macrophages matrix metalloproteinase matrix metalloproteinases Mild disease PAI-1 Patient Potential biomarker potential biomarkers predict pulmonary Pulmonary pathology respiratory Respiratory failure respiratory tract infection response risk factor Risk factors severe COVID-19 severe disease single-cell susceptibility Symptom Th17 TLR7 TLR8 Toll-like receptor toll-like receptor 7 type I interferon with mild disease
[DOI] 10.3390/v13060957 PMC 바로가기 [Article Type] Communication

Differentially expressed immune response genes in COVID-19 patients based on disease severity

질병 중증도에 따라 COVID-19 환자에서 차등적으로 발현되는 면역 반응 유전자

Research Paper

Published on 2021-04-152022-09-10
Journal: Aging (Albany NY) [Category] SARS, 유전자 메커니즘,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antiviral antiviral genes APOBEC3G Apolipoprotein Apolipoprotein B appear blood sample Blood samples case-control study catalytic changes in chemokine chemokines city collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL10 CXCL11 CXCL9 cytokine Cytokines death decreased expression disease Disease progression disease severity domain downregulated dysregulated immune response dysregulated immune responses enzyme expressed FADD Gene Expression genes encoding healthy control healthy controls healthy subject Host IFN IFNA1 IFNA2 IFNAR1 IL12A IL12B IL15 IL1B IL6 Illness severity immune response gene immune response genes immune responses induction IRF7 ISG15 microRNA mRNA MX1 Patient patients PCR progression Proinflammatory cytokine proinflammatory cytokines Protein recovered COVID-19 patient recruited respiratory RNA extraction SARS-CoV-2 SARS-COV-2 infection second severe acute respiratory syndrome Coronavirus Signaling significantly thought TLR8 TLR9 type I interferon underlie upregulated
[DOI] 10.18632/aging.202877 PMC 바로가기 [Article Type] Research Paper

Virus in the pathogenesis of inflammatory bowel disease: role of Toll-like receptor 7/8/3

Review Article

Published on 2021-01-012022-10-31
Journal: Gastroenterology and Hepatology From Bed to Bench [Category] COVID-19,

[키워드] Activation antagonist antiviral immune responses association bowel cause COVID-19 Critical Crohn’s disease dendritic cells effective evaluated expressed finding help IBD IL-1 IL-6 immune system IMPROVE incidence induce Inflammation Inflammatory Inflammatory bowel disease Inflammatory mediators Influenza inhibitors innate immune interferons (IFNs involved less molecular mechanism Pathogenesis Patient patients Quality of life receptor receptors regulate SARS-CoV-2 shown the disease Therapies TLR TLR pathways TLR7 TLR8 TLRs Toll-like receptor Toll-like receptors Treatment ulcerative colitis understanding Vaccine viral infection virus
PMC 바로가기 [Article Type] Review Article

Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approaches

SARS-COV-2에 대한 차세대 멀티에피토프 기반 백신(MEV) 설계: 면역정보학 및 인실리코 접근법

Research Article

Published on 2020-12-222022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

[키워드] adjuvant Amino acid amino acids analyses antigenic antigenic proteins approach B-cell binding affinity caused conducted coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 demonstrated effective epitope Epitopes Escherichia coli Escherichia coli K-12 system flexible followed by global health security highly antigenic HLA-binding allele HLA-binding alleles human pathogenic toll-like receptors immunogenic profile in silico In silico cloning increased expression indicated K-12 linker MEV MEV codon MEV codons MEV construct MHC class MHC class I MHC class II epitopes molecular molecular docking molecular dynamics multiepitope based vaccine non-allergenic overlapping pandemic pathogenic predicted Protein respiratory Respiratory Coronavirus selected Selected epitopes severe acute respiratory coronavirus significant interaction T-cell target targets Till TLR TLR3 TLR8 Toll-like receptor Vaccine vaccine against SARS-COV-2 vaccine production
[DOI] 10.1371/journal.pone.0244176 PMC 바로가기 [Article Type] Research Article

Anti-COVID-19 multi-epitope vaccine designs employing global viral genome sequences

Bioinformatics

Published on 2020-08-032022-10-28
Journal: PeerJ [Category] COVID-19,

[키워드] alleles Analysis antigenic antigenicity approach approved B cell epitope binding binding affinity caused Complete consensus sequence coronavirus SARS-CoV-2 COVID-19 CTL epitope demonstrated develop epitope epitope mapping Escherichia coli expression Genome GISAID global pandemic global public health HLA HTL immune response Immunity immunogenic potential immunoinformatics in silico interferon molecular docking Multi-epitope vaccine NC_045512.2 non-allergenic ORFs overlapping Phylogeny predicted reading reference genome reference sequence reported Result retrieved SARS-CoV-2 SARS-CoV-2 strain screened significantly the Coronaviridae TLR8 Treatment Vaccine viral genome sequence viral strains was performed
[DOI] 10.7717/peerj.9541 PMC 바로가기 [Article Type] Bioinformatics

Vaccine Design from the Ensemble of Surface Glycoprotein Epitopes of SARS-CoV-2: An Immunoinformatics Approach

Article

Published on 2020-07-282022-10-28
Journal: Vaccines [Category] COVID-19,