SARS-CoV-2 primed platelets–derived microRNAs enhance NETs formation by extracellular vesicle transmission and TLR7/8 activationarticle Published on 2023-10-302024-09-05 Journal: Cell Communication and Signaling : CCS [Category] update2024, [키워드] COVID-19 Extracellular vesicles MicroRNAs Platelets, NETs TLR8 [DOI] 10.1186/s12964-023-01345-4 PMC 바로가기 [Article Type] article
TLR8 agonist partially improves IFN-γ deficiency of NK cells in chronic hepatitis B through the synergy of monocytesArticle Published on 2023-02-012023-06-13 Journal: Alimentary pharmacology & therapeutics [Category] B형 간염, [키워드] Chronic Hepatitis B IFN-γ IL-10 Natural killer cells TLR8 [DOI] 10.1111/apt.17382
Nucleic acid-sensing toll-like receptors: Important players in Sjögren’s syndromeReview Published on 2022-10-312023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] Autoimmunity COVID-19 nucleic acid-sensing TLRs Sjögren’s syndrome systemic lupus erythematosus TLR7 TLR8 TLR9 [DOI] 10.3389/fimmu.2022.980400 PMC 바로가기 [Article Type] Review
TLR8 is activated by 5′-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathwayArticle Published on 2022-04-122024-08-28 Journal: Cell Reports [Category] 말라리아, [키워드] 5ʹ-methylthioadenosine 5ʹ-methylthioinosine CP: Immunology CU-CPT9a immucillin Monocytes MTA MTI PBMC Plasmodium falciparum TLR8
Role of toll-like receptors in modulation of cytokine storm signaling in SARS-CoV-2-induced COVID-19SARS-CoV-2로 유발된 COVID-19에서 사이토카인 폭풍 신호전달의 조절에서 톨 유사 수용체의 역할Review Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료법, [키워드] Balanced Blood circulation COVID-19 cytokine Cytokine storm Cytokine storms Cytokines death driving dsRNA Elimination endosomal Factor help IL-1β IL-4 IL-6 IL-8 Imbalance immune regulation individual Inflammatory inflammatory signaling innate immune system interferon interleukin killing MAPK membrane-bound modulation multiple organ failure multiple organ failures multiple-organ multiple-organ failure Necrosis NF-κB nonself other organs pathogen Pro-inflammatory genes pro-inflammatory mediator pro-inflammatory mediators recognize recognizing replicate role SARS-CoV-2 Signaling ssRNA ssRNA. systemic circulation the cytokine storm TLR TLR3 TLR4 TLR7 TLR7/8 TLR8 TLRs Toll-like receptor Toll-like receptors Transcription translation TRIF Tumor tumor necrosis tumor necrosis factor [DOI] 10.1002/jmv.27405 PMC 바로가기 [Article Type] Review
Innate immune response analysis in COVID-19 and kawasaki disease reveals MIS-C predictorsCOVID-19 및 가와사키병의 타고난 면역 반응 분석은 MIS-C 예측 인자를 밝힙니다Article Published on 2022-03-012022-09-11 Journal: Journal of the Formosan Medical Association = Taiw [Category] SARS, 변종, 치료기술, [키워드] acute SARS-CoV-2 infection Adults analyses Analysis ArrayExpress association Blood blood cell Blood cells CASP1 CD14 CD36 children Cohort correlated COVID-19 COVID-19 diagnosis COVID-19 severity dataset determine disease downloaded dysregulated dysregulation enriched pathway enriched pathways expression level FCGR2A gene expression signature genetic polymorphisms HLA-DOB IFI16 IFNAR1 immune dysregulation immune response immune responses increased expression Inflammatory Innate innate immune innate immune gene innate immune genes innate immune response Innate immunity Interaction interactions irak4 IRF3 Kawasaki disease MIS-C moderate Multisystem inflammatory syndrome network network analysis NLRP3 pathway Patient PELI1 polymorphism predict predictor predisposition Pycard reveal SARS-CoV-2 infections severe COVID-19 severity STAT3 STING susceptibility syndrome TLR2 TLR7 TLR8 Transcriptome transcriptome datasets transcriptomes variant variants was used with COVID-19 [DOI] 10.1016/j.jfma.2021.06.009 PMC 바로가기 [Article Type] Article
High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike AntigensObservation Published on 2022-02-162022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, COVID19(2023년), SARS, [키워드] adjuvant aluminum animal models Antigen Beta candidate vaccine Combination COVID-19 COVID-19 vaccine defined Delta delta variant distribution driven by Efficacy elevated humoral hydroxide immune response Immunity immunity after vaccination immunogenic in vitro induced mice NAb NAb titer NAbs neutralize Neutralizing Pathways plasma produced PROTECT Protective protective immunity Protein receptor response Safe SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant SARS-CoV-2 variants sera spike Spike protein subunit Subunit vaccine Support sustained the SARS-CoV-2 TLR TLR8 trimeric trimeric spike vaccination Vaccine vaccine candidate variant [DOI] 10.1128/spectrum.01695-21 PMC 바로가기 [Article Type] Observation
Molecular docking of SARS-COV-2 Spike epitope sequences identifies heterodimeric peptide-protein complex formation with human Zo-1, TLR8 and brain specific glial proteinsSARS-COV-2 스파이크 에피토프 서열의 분자 도킹으로 인간 Zo-1, TLR8 및 뇌 특이적 신경교 단백질과의 이종이량체 펩티드-단백질 복합체 형성 확인Article Published on 2021-12-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 유전자 메커니즘, [키워드] allele asphyxia binding Blood brain barrier blurred vision Brain Brain infection cause clinical observation clinical observations complex death deviation docking epitope epitope peptide Epitopes experiment Glia glial cell headache heterodimeric HLA-DRB1 Human brain human population Hypothesis identify immunogenic induce infect Infection Inflammation Interaction Loss of Smell mechanism modify molecular molecule NDRG2 neurological abnormalities neurological abnormality observation observations peptide peptides performed Protein Proteins question receptor respiratory tract illness RMSD root S100B SARS-CoV-2 SARS-COV-2 infection selected sequence specific protein spike spike epitopes Spike protein structures Symptoms tested the Spike TLR TLR8 Toll-like receptor VCAM1 virus working hypothesis zonula zonula occludens [DOI] 10.1016/j.mehy.2021.110706 PMC 바로가기 [Article Type] Article
Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome무증상 코비드 -19 감염에서 상향 조절 된 유형 I 인터페론 반응은 개선 된 임상 결과와 관련이 있습니다.Article Published on 2021-11-252022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 치료법, 치료제, [키워드] Antigen presentation approach Asymptomatic Asymptomatic cases Asymptomatic COVID-19 Biomarker Biomarkers blood transcriptome CD177 Clinical outcome Computational biology and bioinformatics COVID-19 COVID-19 case COVID-19 disease disease Disease progression downregulated downregulation dysregulation early response early stage effectively controlled help Host humoral ICAM3 IFN IFNAR2 immunology IMPROVE Infection Inflammatory initial interferon interferons IRF2BP1 IRF2BP2 IRF2BPL IRF4 ISG ISGs limit marker MAVS Microbiology Mild mRNA translation neutrophil pathway Pathways progressive disease protective mechanism protective mechanisms response SAMHD1 SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severity of COVID-19 significantly SOCS3 stimulated suppression symptomatic disease These data TLR8 Transcriptome Treatment type I interferon type I interferons understanding uninfected upregulated upregulation Viral [DOI] 10.1038/s41598-021-02489-4 PMC 바로가기 [Article Type] Article
Novel ACE2 protein interactions relevant to COVID-19 predicted by evolutionary rate correlationsBioinformatics Published on 2021-09-152022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] ACE2 ACE2 protein ACE2 receptor affecting androgen approach bind biological interaction candidate caused cell receptor Chronic illness clusterin Coagulation coagulation pathways coevolution component connection contributing to coronavirus coronavirus SARS-CoV-2 correlated correlation COVID-19 cytokine signaling Cytokine storms detect disease manifestation enzyme ERC Evolution Evolutionary inference Evolutionary rate Extracellular factor V FGA FGB FGG fibrinogen function GPR141 human cells identify IFNAR2 immune response Immunity infect Inflammatory response information interact Interaction interactions involved mammalian mammalian protein novel organ systems pandemic disease pathogen Pathologies pathology pathway predict predicted Protein protein interaction Protein networks Proteins reported Respiratory disease SARS-COV-2 infection severe COVID-19 suggestion the disease TLR8 Treatment XCR1 [DOI] 10.7717/peerj.12159 PMC 바로가기 [Article Type] Bioinformatics