CpG-Adjuvanted Hepatitis B Vaccine (HEPLISAV-B®) UpdateReview Published on 2021-05-012023-06-11 Journal: Expert review of vaccines [Category] B형 간염, [키워드] anti-HBsAg antibody CpG adjuvant Engerix-B Hepatitis B virus injection site reaction poor responder recombinant vaccine Sci-B-Vac Seroprotection rate TLR9 [DOI] 10.1080/14760584.2021.1908133 [Article Type] Review
Differentially expressed immune response genes in COVID-19 patients based on disease severity질병 중증도에 따라 COVID-19 환자에서 차등적으로 발현되는 면역 반응 유전자Research Paper Published on 2021-04-152022-09-10 Journal: Aging (Albany NY) [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antiviral antiviral genes APOBEC3G Apolipoprotein Apolipoprotein B appear blood sample Blood samples case-control study catalytic changes in chemokine chemokines city collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL10 CXCL11 CXCL9 cytokine Cytokines death decreased expression disease Disease progression disease severity domain downregulated dysregulated immune response dysregulated immune responses enzyme expressed FADD Gene Expression genes encoding healthy control healthy controls healthy subject Host IFN IFNA1 IFNA2 IFNAR1 IL12A IL12B IL15 IL1B IL6 Illness severity immune response gene immune response genes immune responses induction IRF7 ISG15 microRNA mRNA MX1 Patient patients PCR progression Proinflammatory cytokine proinflammatory cytokines Protein recovered COVID-19 patient recruited respiratory RNA extraction SARS-CoV-2 SARS-COV-2 infection second severe acute respiratory syndrome Coronavirus Signaling significantly thought TLR8 TLR9 type I interferon underlie upregulated [DOI] 10.18632/aging.202877 PMC 바로가기 [Article Type] Research Paper
Treatment with the Immunomodulator AIC649 in Combination with Entecavir Produces Antiviral Efficacy in the Woodchuck Model of Chronic Hepatitis BArticle Published on 2021-04-092023-06-02 Journal: Viruses [Category] B형 간염, [키워드] parapoxvirus antiviral efficacy Chronic Hepatitis B entecavir immune response TLR9 Woodchuck [DOI] 10.3390/v13040648 PMC 바로가기 [Article Type] Article
Cell-free DNA maps COVID-19 tissue injury and risk of death and can cause tissue injury무세포 DNA는 COVID-19 조직 손상과 사망 위험을 매핑하고 조직 손상을 유발할 수 있습니다.Multicenter Study Published on 2021-04-082022-09-10 Journal: JCI Insight [Category] MERS, SARS, 바이오마커, 진단, [키워드] (cfDNA adipocytes Admission Analysis analyzed bioinformatics Biomarker bisulfite bisulfite sequencing C-reactive protein cell-free DNA cfDNA Clinical course Comparator group conducted contribute coronavirus Coronavirus 2019 correlation COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient D-dimer death died disease severity DNA DNA methylation elevated funding healthy control healthy controls heart hematopoietic cells hepatocytes heterogeneous Hospitalization Inflammation Influenza inhibited Injury intensive care Intramural kidney library lung measure Mild mitochondrial Molecular genetics multicenter multiorgan failure NIH outcome outcomes Patient patients with COVID-19 performed plasma samples positively correlated predict prospective cohort study renal tubular cell renal tubular cells required respiratory syncytial virus risk of death ROS sequence subject tissue tissue injury tissue source TLR9 to define Trajectories tubular cells Vascular endothelium was used with COVID-19 [DOI] 10.1172/jci.insight.147610 PMC 바로가기 [Article Type] Multicenter Study
Adjuvanting a subunit COVID-19 vaccine to induce protective immunity Research Published on 2021-04-012022-10-05 Journal: Nature [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] adjuvant adjuvants AS03 B.1.1.7 SARS-CoV-2 variant B.1.351 B.1.351 variant breadth Bronchoalveolar lavage CD4 clinical trial correlated COVID-19 vaccine domain Efficacy evaluated FIVE HexaPro highlight immunization immunized immunogenic induce Infection Live virus nare neutralization Neutralizing-antibody produced protective immunity Protein public health reduced reduction in response rhesus macaques robust SARS-CoV-2 SARS-COV-2 infection Spike protein stimulate subunit T cell responses the SARS-CoV-2 TLR7 TLR9 toll-like receptor 7 vaccinate vaccination Vaccine [DOI] 10.1038/s41586-021-03530-2 [Article Type] Research
S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates코로나19 소단위 백신 후보 S-트리머, 비인간 영장류 보호 면역 유도Article Published on 2021-03-012022-09-12 Journal: Nature Communications [Category] SARS, 변종, 비임상, 임상, 진단, 치료기술, 치료법, [키워드] adjuvant alum animal model animal models Antigen AS03 Cellular immune response clinical observation clinical observations controls COVID-19 COVID-19 pandemic CpG effective enveloped RNA viruses host cells immune responses immunization immunized immunogenicity induce Like Lungs Neutralizing antibodies neutralizing antibody non-human primates pandemic platform protective immunity reduction rhesus macaque rhesus macaques RNA viruses Safe SARS-CoV-2 SARS-CoV-2 spike protein Spike protein subunit Subunit vaccine surface antigen TLR9 trimeric Vaccine vaccine candidate Vaccines Viral load viral loads water [DOI] 10.1038/s41467-021-21634-1 PMC 바로가기 [Article Type] Article
Innate Receptor Activation Patterns Involving TLR and NLR Synergisms in COVID-19, ALI/ARDS and Sepsis Cytokine Storms: A Review and Model Making Novel Predictions and Therapeutic SuggestionsReview Published on 2021-02-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] “cytokine storm” activate Activation acute lung injury acute lung injury (ALI) acute respiratory distress acute respiratory distress syndrome (ARDS) Bacterial Bacterial coinfection characteristic characterized Combination coronavirus COVID-19 Cytokine release syndrome Cytokine storm effective eight Evidence exhibiting fungal fungal coinfection Fungal infection fungal infections healthy control hyperinflammation implication Infection Innate Innate immunity Interaction Involving Making mechanism melatonin microbes Mild mild cases mild COVID-19 patient Model NLR NLRP3 novel nucleotide-oligomer-recognition-domain-like receptors (NLR) oligomerization outlined pattern prediction receptor respiratory resulting review SARS-CoV-2 Sepsis severe COVID-19 severe COVID-19 patients suggestion Symptoms syndrome synergistic synergy therapeutic TLR TLR antagonists TLR2 TLR3 TLR4 TLR7 TLR9 Toll-like receptor toll-like receptors (TLR) treating COVID-19 [DOI] 10.3390/ijms22042108 PMC 바로가기 [Article Type] Review
TLR9 and COVID-19: A Multidisciplinary Theory of a Multifaceted Therapeutic TargetPharmacology Published on 2021-01-152022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] adjuvant agonist Biomarker clinical testing Complication coronavirus 2 Coronavirus disease 2019 COVID-19 disorder drug candidate drug target identification Epidemiology explain favor healthcare hyperinflammation Hypothesis identify immune immunology individual Intervention introduced lack late stage limitation manifestation manuscript mechanism of action medical need mitochondrial DNA modulating novel coronavirus disease onset of disease pathogen pathogenesis of COVID-19 pathophysiology Patient prevented preventive measures Prophylactic reached receptor resource respiratory risk severe acute respiratory syndrome coronavirus 2 severe COVID-19 target theory therapeutic thrombotic complication TLR9 toll-like receptor 9 Treatment Vaccine vulnerable patient [DOI] 10.3389/fphar.2020.601685 PMC 바로가기 [Article Type] Pharmacology
Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19Article Published on 2020-11-182022-10-04 Journal: Scientific Reports [Category] 변종, 치료기술, [키워드] addition Administered adverse effect aluminum applied candidate vaccine Combination COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 vaccine CpG cross-neutralize cytokine D614G variant development dominant elicited ENhance health emergency hydroxide immunized immunized mice immunology immunopathology lentivirus MERS-CoV mice Microbiology mitigate neutralizing antibody prefusion Prevent pseudotyped pseudovirus reporter S-2P SARS-CoV-2 spike antigen SARS-CoV-2 spike protein secreted sera splenocyte subunit Support Th1 the antibody the spike protein TLR9 Toll-like receptor Treatment two-dose regimen Vaccine was selected wild-type SARS-CoV-2 [DOI] 10.1038/s41598-020-77077-z PMC 바로가기 [Article Type] Article
Designing spike protein (S-Protein) based multi-epitope peptide vaccine against SARS COVID-19 by immunoinformaticsResearch article Published on 2020-11-162022-10-05 Journal: Heliyon [Category] 유전자 메커니즘, [키워드] AAY analysed antigenic approach B-cell bioinformatics China computational approach Concentration conducted COVID 19 COVID-19 COVID-19 infection criteria cytotoxic develop docking EAAAK linker effective effective drug Effectiveness epitope experiment expressed expression GPGPG help Humoral immunity immune response Immune simulation immunogenic immunoinformatics induce Interaction Laboratory linkers molecular docking Multi-epitope multi-epitope peptide vaccine outbreak peptide peptides physiochemical properties predicted Protein Proteins respiratory responsible SARS-COVID 19 scientist selected Spike protein T-cell TLR TLR3 TLR4 TLR9 vaccination Vaccine vaccine construct viral disease virus was performed was used β-defensin [DOI] 10.1016/j.heliyon.2020.e05528 [Article Type] Research article