Towards Covid-19 TMPRSS2 enzyme inhibitors and antimicrobial agents: Synthesis, antimicrobial potency, molecular docking, and drug-likeness prediction of thiadiazole-triazole hybridsResearch article Published on 2022-11-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] 1 2 3 3-Triazoles 4-Thiadiazole analogue antimicrobial activity Bacillus subtilis binding affinity Candida albican candidate chalcone chloride Compound COVID-19 drug-likeness enzyme Escherichia coli exhibited FIVE Hydrazonoyl halides identify in silico in vitro inhibitor molecular docking pathogen Prevent proliferation Pseudomonas aeruginosa screened Staphylococcus aureus submitted synthesis synthesised therapeutic activity TMPRSS2 TMPRSS2 enzyme transmembrane serine protease Treatment Vanillin was tested [DOI] 10.1016/j.molstruc.2022.133659 [Article Type] Research article
Expression of SARS-Cov-2 Entry Factors in Patients with Chronic HepatitisArticle Published on 2022-10-292023-07-10 Journal: Viruses [Category] COVID19(2023년), [키워드] ACE2 chronic hepatitis. NAFLD SARS-CoV-2 TMPRSS2 [DOI] 10.3390/v14112397 PMC 바로가기
Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airwaysArticle Published on 2022-10-282022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 airway airway epithelium airways association C15orf48 cell population changes in characterized club co-expressed cohorts CTSL diagnostic workup disease severity elevated epithelial cells expressed expressing expression expression data Gene Expression gene expression pattern Goblet cell increase in indicated individual Infection lung cancer lung cancer risk modulate modulated nasal Population SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection scRNA-seq secretory cell severe disease significantly similarity smoker smoking smoking status subpopulation TMPRSS2 viral entry Viral load [DOI] 10.1038/s41598-022-17832-6 PMC 바로가기
Genetic Association between ACE2 (rs2285666 and rs2074192) and TMPRSS2 (rs12329760 and rs2070788) Polymorphisms with Post-COVID Symptoms in Previously Hospitalized COVID-19 SurvivorsArticle Published on 2022-10-242023-07-10 Journal: Genes [Category] COVID19(2023년), [키워드] ACE2 long-COVID Post-COVID single nucleotide polymorphism. TMPRSS2 [DOI] 10.3390/genes13111935 PMC 바로가기
Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and ReplicationArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Alpha Altered Anti-viral Anti-viral therapy Antiviral assays biological molecules cathepsin L Cell cell entry cellular proteases cleaved designer serpin effective enzyme expressing facilitate furin furin. generate host cell protease implicated in vitro infection with SARS-CoV-2 inhibit inhibition inhibitor inhibitors inhibitory inhibitory activity loop membrane fusion Mutagenesis P681R predicted produced protease Protein purified rate constant reactive Recombinant protein S protein cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral replication SARS-CoV-2 virus serine 2 serine protease inhibitor SerpinB3 shown specificity suppress target the Spike the spike protein TMPRSS2 transmembrane variant Vero E6 cell [DOI] 10.3390/ijms232012522 PMC 바로가기
Host Genetic Risk Factors Associated with COVID-19 Susceptibility and Severity in VietnameseArticle Published on 2022-10-182022-11-16 Journal: Genes [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ABO ABO blood type ADAM17 allele association Blood Control COVID-19 COVID-19 patient DPP9 Europe Factor Frequency Genetic Genetic variant Genotype Host host gene host genetic variants IFNAR2 immune system increased the risk infected individuals Infection mechanism moderate outcome outcomes Pathogenesis Population protective factor reduced SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 susceptibility searched sensitivity significantly significantly higher SLC6A20 Symptoms TMPRSS2 transmission of SARS-CoV-2 TYK2 variant virus whole-exome data whole-exome sequencing whole-exome sequencing. with COVID-19 [DOI] 10.3390/genes13101884 PMC 바로가기
Why Does the Omicron Variant Largely Spare Olfactory Function? Implications for the Pathogenesis of Anosmia in Coronavirus Disease 2019Article Published on 2022-10-172022-11-16 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome alkaline Anosmia cause Cell coronavirus COVID-19 D614G D614G mutation Efficiency Express expressing host cell hydrophobic less Loss of Smell Mucus Mutation olfactory dysfunction Olfactory epithelium olfactory function omicron Omicron variant penetration potential mechanism Prevalence Prevalence. Receptor binding reduce reduced SARS-CoV-2 Support target cell tissue tropism TMPRSS2 transmembrane serine protease variants [DOI] 10.1093/infdis/jiac113 PMC 바로가기
Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airwaysArticle Published on 2022-10-152022-11-16 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] airway airways Analysis Beta calu-3 cells cathepsin-dependent Cell cleavage cultured cells Essential furin Gamma host proteases in vivo infect Infection isolate mice mouse-adapted SARS-CoV-2 multiple pathway murine omicron pathway recent reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants shown significantly the spike protein TMPRSS2 variant [DOI] 10.1038/s41467-022-33911-8 PMC 바로가기
Molecular mechanisms involved in anosmia induced by SARS-CoV-2, with a focus on the transmembrane serine protease TMPRSS2막횡단 세린 프로테아제 TMPRSS2를 중심으로 SARS-CoV-2에 의해 유도된 후각장애와 관련된 분자 기전Review Published on 2022-10-012022-09-11 Journal: Archives of Virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Anosmia Apoptosis blockade camostat caused cell entry cellular and molecular chromosome chromosome 21 cleaving Delta dependent on disease disorder dysfunction entry of SARS-CoV-2 event ExoN exons facilitate functional gene encoding Genetic variations help host cell Inflammation involved mechanism nafamostat neuronal number of symptoms olfactory dysfunction olfactory neuroepithelium omicron overcome pandemic virus receptor receptors risk SARS-CoV-2 Serine serine protease serine protease inhibitor serine protease inhibitors shown strain Strains Symptoms therapeutic TMPRSS2 transmembrane serine protease viral S protein virus [DOI] 10.1007/s00705-022-05545-0 PMC 바로가기 [Article Type] Review
Proviral role of human respiratory epithelial cell-derived small extracellular vesicles in SARS-CoV-2 infectionArticle Published on 2022-10-012023-07-10 Journal: Journal of Extracellular Vesicles [Category] COVID19(2023년), [키워드] human nasal epithelial cells SARS-CoV-2 small extracellular vesicles. Spike prefusion priming TMPRSS2 [DOI] 10.1002/jev2.12269 PMC 바로가기