Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics녹농균(Pseudomonas aeruginosa): 병인, 독성 인자, 항생제 내성, 숙주와의 상호 작용, 기술 발전 및 새로운 치료법Review Published on 2022-06-252022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 유전자 메커니즘, [키워드] addition Antibiotic resistance Antibiotics antimicrobial autophagy Bacterial Bacterial pathogenesis bioinformatics burn wounds Cancer caused Cell signaling cGAS chronic obstructive clinically COPD COVID-19 CRISPR CRISPR-Ca cystic fibrosis Defense develop disorder drug drug resistance Drug screening effective effort Factor Factors fibrosis gram Host host defense host immune responses host-pathogen interaction immune immune responses immunodeficiency IMPROVE infect Infection infections Inflammasome Interaction intractable invasive LPS mammalian cell mechanism metabolomics molecular Non-coding RNAs opportunistic pathogen outer membrane P. aeruginosa pathogen Pathogenesis Pathways Patient platform Pseudomona Pseudomonas aeruginosa rapid progress Regulation Research scRNA-seq secretion Severe infection signaling pathways Strains therapy traits treat use of antibiotics Ventilation Vesicle virulence widespread [DOI] 10.1038/s41392-022-01056-1 PMC 바로가기 [Article Type] Review
Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies Research Published on 2022-06-072022-10-05 Journal: Nature Communications [Category] 신약개발, 유전자 메커니즘, 임상, 치료제, [키워드] approach association competing Computational drug conformation ENhance epigenomic epigenomics eQTL expression expressions extension gene expression level genomic help increase independent Informed loci median Model outperform predict prediction Quantitative Region target gene traits transcriptome-wide variants [DOI] 10.1038/s41467-022-30956-7 [Article Type] Research
Coronavirus and Paramyxovirus Shedding by Bats in a Cave and Buildings in Ethiopia에티오피아의 동굴과 건물에서 박쥐에 의한 코로나바이러스 및 파라믹소바이러스 발산Article Published on 2022-06-012022-09-11 Journal: EcoHealth [Category] COVID19(2023년), SARS, 치료기술, [키워드] alphacoronavirus bat bats Biogeography building cave Combination Consensus coronavirus CoV dependent on Diversity Ethiopia expand Factor filoviruses FIVE geographic locations Host immunology include Infection knowledge life history Novel coronavirus pandemic paramyxovirus PCR assay positive rectal swab Rectal swabs risk reduction SARS-CoV SARS-CoV-2 shedding stressors Surveillance tested traits Transmission viral infection viral shedding virus wet season wildlife zoonotic zoonotic disease [DOI] 10.1007/s10393-022-01590-y PMC 바로가기 [Article Type] Article
Evidence of partner similarity for autistic traits, systemizing, and theory of mind via facial expressions Research Published on 2022-05-192022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] Analysis autism autistic correlation Effect effect size empathy evidence of examined expression eye facial figure hypothesised indicate indicated initial investigated lab measure mind phenotypic positive predicted reading recruited seeking similarity Spectrum statistically significant Stratification Test traits [DOI] 10.1038/s41598-022-11592-z [Article Type] Research
Shared genomic architectures of COVID-19 and antisocial behaviorCOVID-19의 공유 게놈 구조와 반사회적 행동Article Published on 2022-05-102022-09-11 Journal: Translational Psychiatry [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggression antisocial antisocial behavior average average income baby calculate cause chronic obstructive chronic obstructive pulmonary disease coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 Diseases estimate exposure to false-discovery rate Genetic genetics Genome-wide association studies Genome-wide association study genomic Health higher risk Linkage disequilibrium matrix measure mind obstructive pulmonary disease omicron overlap pandemic pulmonary disease SARS-CoV-2 severe acute respiratory syndrome Coronavirus text traits Vaccine variant verbal with COVID-19 [DOI] 10.1038/s41398-022-01948-4 PMC 바로가기 [Article Type] Article
Evolution of the human pathogenic lifestyle in fungi Reviews Published on 2022-05-042022-10-05 Journal: Nature Microbiology [Category] 유전자 메커니즘, [키워드] contribute contributed death develop drug ecological elements Evolution fungal fungal pathogen fungi Genetic genetic difference Genetic variation helping human infection insight mechanism pathogen pathogenic pathogenicity predict resulting traits understanding [DOI] 10.1038/s41564-022-01112-0 [Article Type] Reviews
Personality, gender, and age resilience to the mental health effects of COVID-19Research article Published on 2022-05-012022-10-05 Journal: Social science & medicine (1982) [Category] 유전자 메커니즘, [키워드] adaptive affected age assist can be used Characteristics Cohort COVID-19 COVID-19 pandemic Critical Effect event extroversion fixed Gender help identify Impact increase in individual individuals knowledge loneliness Longitudinal data Mental mental health objective occur Other pandemic Personality promote Psychological Psychological distress public health rationale Resilience response Result Support Symptom traits understanding worsening young adults [DOI] 10.1016/j.socscimed.2022.114884 [Article Type] Research article
The cannabinoid receptor-1 gene interacts with stressful life events to increase the risk for problematic alcohol use칸나비노이드 수용체-1 유전자는 스트레스가 많은 생활 사건과 상호작용하여 문제가 있는 알코올 사용의 위험을 증가시킵니다Article Published on 2022-03-232022-09-11 Journal: Scientific Reports [Category] 변종, [키워드] Activation adulthood Affect alcohol Alcohol Use Disorders Identification Test association Audit baseline binding Brain childhood CNR1 conducted COVID-19 pandemic Cross-sectional analyses cross-sectional analysis death develop disorders DNA event Evidence Factor functional Genetic variant genetic variants Genome-wide association study genotyped habituation humans identification identify implicated interact Interaction interactions Model Neuroticism not significant nucleotide outcome outcomes Personality Trait polymorphism predicted predictor provided Psychiatric public health reason for receptor repeated reported Research risk risk allele single nucleotide Single nucleotide polymorphism SLE Stress Stressor stressors substance Substance use substance use disorders Support Swedish targets Test traits Treatment turn [DOI] 10.1038/s41598-022-08980-w PMC 바로가기 [Article Type] Article
Integrative transcriptomic, evolutionary, and causal inference framework for region-level analysis: Application to COVID-19 Research Published on 2022-03-222022-10-05 Journal: NPJ Genomic Medicine [Category] 바이오마커, 신약개발, 유전자 메커니즘, [키워드] Analysis application applied approach average CCR5 CCR9 complications Concentration COVID-19 COVID-19 severity CXCR6 disease expression Genes Gustatory higher risk host genetics Immunity implication individual Inflammatory locus methodology molecular mechanism much higher olfactory phenotype severe COVID-19 severe disease severity SLC6A20 traits transcriptomic [DOI] 10.1038/s41525-022-00296-y [Article Type] Research
COVID-19 Vaccination and Mental Disorders, What Has Been Accomplished and Future DirectionPerspective Published on 2022-02-202022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] accompanied Affect Compliance consequence COVID-19 COVID-19 vaccination COVID-19 vaccine direction evaluate Factor Future General population implementation investigated involved Mental Disorders mental health negative emotion pandemic pathology Psychiatric psychiatry PTSD Scientific community Side effect the vaccine traits Vaccine Vaccine hesitancy [DOI] 10.3390/brainsci12020292 PMC 바로가기 [Article Type] Perspective