Simultaneous monitoring of eight human respiratory viruses including SARS-CoV-2 using liquid chromatography-tandem mass spectrometry액체 크로마토그래피-탠덤 질량분석기를 이용한 SARS-CoV-2를 포함한 8종의 인간 호흡기 바이러스 동시 모니터링Article Published on 2022-08-042022-09-11 Journal: Scientific Reports [Category] SARS, 신종인플루엔자, 진단, 치료기술, 치료제, [키워드] 229E absence acute infection acute respiratory syndrome coronavirus applied Chain Reaction characterisation clinical sample clinical samples conditions coronavirus 2 Coverage Culture Diagnosis eight H1N1 H3N2 human respiratory virus Infection Influenza Influenza A/H1N1 influenza B information liquid Liquid chromatography mass spectrometry moderate not used nucleoprotein OC43 Orf9b peptide peptides polymerase chain polymerase chain reaction positive presence or absence Protein proteomics provide Replication respiratory respiratory virus respiratory viruses reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 ORF9b serology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simultaneous specimens Tandem mass spectrometry the SARS-CoV-2 transcriptase viral infection Viral load Viral protein Viral proteins Viral RNA virus virus replication [DOI] 10.1038/s41598-022-16250-y PMC 바로가기 [Article Type] Article
A randomized, controlled, blinded, parallel group, clinical trial to study the role of Ayurcov (AyurCoro3), one day regimen as an adjuvant therapy for COVID-19 disease management, at dedicated Covid Hospital (DCH) in India인도의 코비드 전용 병원(DCH)에서 COVID-19 질병 관리를 위한 보조 요법으로서 Ayurcov(AyurCoro3)의 역할을 연구하기 위한 무작위, 통제, 맹검, 병렬 그룹 임상 시험Randomized Controlled Trial Published on 2022-08-012022-09-11 Journal: Complementary therapies in medicine [Category] SARS, 임상, 치료제, [키워드] adjuvant adverse events alternative medicine alum Antiviral Ayurcov Ayurveda blinded CAM carried Chain Reaction clinical trial complementary Complementary and alternative medicine. control group Controlled trial COVID-19 COVID-19 disease COVID-19 infections Ct values Curcuma Day diagnosed discharge disease dose evaluate Formulation functional Functional status higher risk India ingredient Limited management Mild mild to moderate Mild-to-moderate milk moderate outcome parallel group Patient polymerase chain polymerase chain reaction proportion Randomized real time receiving recruited reduction in regimen resolution of symptom reverse transcriptase Reverse transcriptase polymerase chain reaction Rock Candy rRT-PCR severe COVID-19 disease Severe COVID-19 Infection severe symptoms severity significantly significantly lower significantly more Sita Standard of care Symptom symptom resolution therapeutic effect therapeutic options therapy for COVID-19 transcriptase Treatment Urine [DOI] 10.1016/j.ctim.2022.102824 PMC 바로가기 [Article Type] Randomized Controlled Trial
Repeated transmission of SARS-CoV-2 in an overcrowded Irish emergency department elucidated by whole-genome sequencing전체 게놈 시퀀싱으로 밝혀진 과밀 아일랜드 응급실에서 SARS-CoV-2의 반복 전파Article Published on 2022-08-012022-09-11 Journal: The Journal of hospital infection [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis assigned B.1.1.7 B.1.1.7 lineage bioinformatics Chain Reaction Cluster Community complex consensus genome Contact tracing COVID COVID-19 COVID-19 pandemic defined demonstrated effort emergency department epidemiologically Genomic epidemiology hospital Hospital overcrowding hospital ward Infection infections Limerick Local maximum-likelihood nasopharyngeal swabs occurred outbreak Outbreak investigation Oxford pangolin Patient Phylogenetic tree polymerase chain polymerase chain reaction Prevent Prevention and control protocol resulting reverse transcriptase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections sequence Sequencing Single nucleotide polymorphism SNPs surveillance testing threshold transcriptase Transmission transmission of SARS-CoV-2 university Viral RNA viral RNA extracted Viral transmission was performed WGS whole-genome sequencing [DOI] 10.1016/j.jhin.2022.04.015 PMC 바로가기 [Article Type] Article
Serum SARS-CoV-2 Antigens for the Determination of COVID-19 SeverityCOVID-19 중증도 결정을 위한 혈청 SARS-CoV-2 항원Article Published on 2022-07-282022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Antigen antigenic Antigenic assay Chemiluminescent assay CLIA COVID-19 COVID-19 diagnosis Determination diagnostic disease severity evaluate false-negative false-negative results followed by help intensive care Kinetics likelihood ratio marker N antigen nasopharyngeal non-severe patient non-severe patients onset of symptoms Patient performed polymerase chain reaction polymerase chain reactions positive Prognosis prognosis test. progression provided reverse transcriptase risk RT-PCR RT-PCRs SARS-CoV-2 SARS-COV-2 infection sensitive serum severe and non-severe patients severe COVID-19 severe patients severity Simoa swabs the WHO threshold transcriptase Viremia was determined were measured WHO Clinical Progression Scale [DOI] 10.3390/v14081653 PMC 바로가기 [Article Type] Article
COVID-19 vaccine effectiveness against symptomatic SARS-CoV-2 infection and severe COVID-19 outcomes from Delta AY.4.2: Cohort and test-negative study of 5.4 million individuals in ScotlandDelta AY.4.2의 증상이 있는 SARS-CoV-2 감염 및 심각한 COVID-19 결과에 대한 COVID-19 백신 효과: 스코틀랜드의 540만 개인에 대한 코호트 및 테스트 음성 연구Article Published on 2022-07-092022-09-11 Journal: Journal of Global Health [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 95% CI 95% confidence interval accounted acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults age BNT162b2 ChAdOx1 Chain Reaction cohort study Community conditions conducted confounders contributed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 admission COVID-19 hospitalisation COVID-19 vaccine Cox proportional hazard Cox proportional hazards model death Delta Effectiveness enhanced Good hazard ratio Hospital admission increased risk individual individuals Infection Lineage mRNA mRNA-1273 mRNA-1273 vaccine mRNA-1273 vaccines offered omicron Omicron variant outcome performed platform polymerase chain polymerase chain reaction proportional hazards model provided reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-COV-2 infection second vaccination security severe acute respiratory syndrome Coronavirus severe COVID-19 Sex socioeconomic status spline splines symptomatic symptomatic COVID-19 symptomatic infection symptomatic SARS-CoV-2 infection transcriptase United Kingdom vaccination Vaccine vaccine dose Vaccines variant variant of SARS-CoV-2 were infected [DOI] 10.7189/jogh.12.05025 PMC 바로가기 [Article Type] Article
Breastfeeding during the COVID-19 pandemic: what do we know so far?COVID-19 전염병 동안 모유 수유: 우리는 지금까지 무엇을 알고 있습니까?Review Published on 2022-07-082022-09-11 Journal: Einstein [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition addressed analyzed antibody appear article breast milk Breastfeeding carried Chain Reaction clinical suspicion confirmation COVID-19 Evidence evidence of expressed Health Organization human milk immunological protection Infection International LILACS literature review measure mother National polymerase chain polymerase chain reaction promoted protective factor reverse transcriptase Reverse transcriptase polymerase chain reaction risk Safe SARS-CoV-2 SciELO selected took place transcriptase transfer Transmission vertical transmission Viral RNA with COVID-19 World Health Organization [DOI] 10.31744/einstein_journal/2022RW6609 PMC 바로가기 [Article Type] Review
Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposingReview article Published on 2022-07-012022-10-05 Journal: Drug discovery today [Category] 신약개발, [키워드] active sites affecting AIDS binding both virus cause common drug complexes Diseases drug Drug development drug resistance drugs HBV hepatitis B virus polymerase HIV HIV-1 reverse transcriptase human liver immune system implication inhibitors L-nucleoside opportunity pathogen polymerase problem public health remained repurposing structures transcriptase virus with HIV [DOI] 10.1016/j.drudis.2022.02.016 [Article Type] Review article
SARS-CoV-2 Viral Load Quantification, Clinical Findings and Outcomes in Children Seeking Emergency Department Care: Prospective Cohort StudySARS-CoV-2 바이러스 부하 정량화, 응급실 치료를 원하는 어린이의 임상 결과 및 결과: 전향적 코호트 연구Article Published on 2022-07-012022-09-11 Journal: The Pediatric Infectious Disease Journal [Category] COVID19(2023년), SARS, 치료법, [키워드] 95% CI Chain Reaction children clinical concerning Department digital PCR Emergency false-negative rate finding load negative RT-PCR Nucleocapsid gene PCR testing polymerase chain polymerase chain reaction positive Prospective reverse transcriptase RT-PCR RT-PCR testing SARS-CoV-2 SARS-CoV-2 RT-PCR sensitivities sensitivity specimens transcriptase yielding [DOI] 10.1097/INF.0000000000003527 PMC 바로가기 [Article Type] Article
The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2뉴클레오사이드/뉴클레오타이드 유사체 테노포비르와 엠트리시타빈은 SARS-CoV-2에 대해 비활성입니다Article Published on 2022-06-302022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] accelerated active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity antiviral agent Antiviral agents Antiviral effect approaches approved approved drug biochemical causative pathogen caution Cell clinicians and researcher Concentration coronavirus COVID-19 COVID-19 pandemic demonstrated Efficiency emtricitabine epithelial FTC HIV-1 HIV-1 NRTI human lung in vitro data inactive indicate inhibitor lack metabolite NHBE NTP nucleoside polymerase Prevent RdRP RdRp active site required reverse transcriptase RNA polymerase SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus TAF TDF tenofovir Tenofovir alafenamide the SARS-CoV-2 transcriptase treat unlikely [DOI] 10.3390/molecules27134212 PMC 바로가기 [Article Type] Article
LUNG ULTRASOUND IN OUTPATIENTS WITH COVID-19 INFECTION ASSOCIATED PNEUMONIAConference abstract Published on 2022-06-202022-10-05 Journal: Ultrasound in medicine & biology [Category] 진단, [키워드] 95% CI abnormality Accuracy Analysis blinded calculated chronic heart failure computer tomography correlated COVID-19 COVID-19 infection CT scan cut-off diagnosing Diagnosis diagnostic Diagnostic Criteria disease evaluate examined False positive feature Infection interstitial Interstitial lung disease lung Lung ultrasound material median men Mild moderate nasopharynx objective Outpatient parenchymal consolidation Patient patients Pneumonia point-of-care ultrasonography polymerase chain protocol quantitative assessment respiratory diseases Result Safe SARS-CoV-2 severity significantly subpleural the epidemic transcriptase Ultrasound was performed WHO with COVID-19 women zone [DOI] 10.1016/j.ultrasmedbio.2022.04.023 [Article Type] Conference abstract