Comparison of viral propagation and drug response among SARS-CoV-2 VOCs using replicons capable of recapitulating virion assembly and releaseArticle Published on 2022-10-012022-11-15 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome assays Beta changed coronavirus Delta delta VoCs drug resistance drug response ENhance Evolution of SARS-CoV-2 genomes immune evasion inhibitor manifested Mutation novel antiviral drugs Protein provide quantification released remained Remdesivir replicon RNA S gene SARS-CoV-2 sgRNA supernatant Support Transcription variants variants of concern variants of concern (VOC) viral genome replication viral infectivity viral life cycle viral propagation Viral protein Viral-like particle (VLP). viral-like particles virion assembly VLP VoC VOCs WIV04 strain [DOI] 10.1016/j.virs.2022.06.008 PMC 바로가기
Diagnostic efficiency of RT-LAMP integrated CRISPR-Cas technique for COVID-19: A systematic review and meta-analysisArticle Published on 2022-10-012022-11-15 Journal: Pathogens and global health [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Accuracy applicability article calculated Care chain conducted confidence interval COVID-19 COVID-19 diagnosis COVID-19 pandemic CRISPR-Ca CRISPR-Cas database Diagnosis diagnostic Diagnostic method Efficiency eligibility criteria epidemiological equipment False-positive faster feasible forest plot isothermal amplification limit management Meta-analysis Meta-analysis. molecular N gene Precision problem QUADAS-2 Quantitative reaction Region regions resource reverse transcription RT-LAMP RT-qPCR SARS-CoV-2 sensitivity specificity systematic review Transcription USA was performed with COVID-19 [DOI] 10.1080/20477724.2022.2035625 PMC 바로가기
A quantitative RT-qLAMP for the detection of SARS-CoV-2 and human gene in clinical applicationArticle Published on 2022-10-012022-11-16 Journal: Microbial Biotechnology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] applied BBIBP-CorV Beta clinical sample clinical samples Clinical treatment cycle threshold Delta demonstrated detect evaluate evaluated fluorescent full-length help human gene inactivated isothermal isothermal amplification linear linear relationship management omicron pandemic Patient physician positive qPCR Quantitative required RNA RT-qPCR SARS-CoV-2 swab samples threshold Transcription variants of SARS-CoV-2 Viral load viral loads viral particle was used [DOI] 10.1111/1751-7915.14112 PMC 바로가기
Toehold-controlled ligation and transcription for accurate COVID-19 genotyping정확한 COVID-19 유전자형 분석을 위한 발가락 제어 결찰 및 전사Article Published on 2022-10-012022-09-11 Journal: Analytical biochemistry [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] approach Chain Reaction contagious coronavirus disease Coronavirus disease 2019 COVID-19 feature genotyping global pandemic in vitro transcription isothermal Ligase Ligase chain reaction linear Mutation point-of-care probe risk SARS-CoV-2 SARS-CoV-2 variant SNV SNVs specificity Toehold-mediated strand displacement reaction. Transcription variant virus [DOI] 10.1016/j.ab.2022.114803 PMC 바로가기 [Article Type] Article
Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthmaArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] addition allergic Allergic asthma Analysis approach association Asthma asthmatic bioinformatics Biomarker can be used candidate drug candidate drugs Comorbidity conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression COVID-19 symptom Critical dataset datasets DEGs determine differentially expressed gene disease disease biomarker drug Effect elevated Evidence expression level Gene ontology Genes health systems hub gene identify IL-13 IL-5 Increasing Interaction interactions lung mechanism molecular molecular mechanism MUC5AC murine murine model pandemic pathway Pathway analysis Patient patients with COVID-19 phenotype potential molecular risk factor severity shared pathways statistical Systems biology systems-biology. Transcription [DOI] 10.3389/fimmu.2022.988479 PMC 바로가기
Preclinical findings: The pharmacological targets and molecular mechanisms of ferulic acid treatment for COVID-19 and osteosarcoma via targeting autophagyArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Endocrinology [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] 2019 coronavirus disease activities acute respiratory disease applied autophagy Bioinformatics analysis characterized clinical coronavirus COVID-19 deficiency determine develop Effectiveness Evidence ferulic acid Genes impacted individuals MAPK1 mechanism mechanisms medication methodology molecular docking molecular docking analysis molecular mechanism network pharmacology number of infected Ontology osteosarcoma pandemic pathway enrichment Patient Patients with cancer pharmacological pharmacological target PIK3R1 Population potential therapeutic target Preclinical Protein regulatory subunit SARS-CoV-2 STAT3 target targets therapeutic therapeutic targets therapeutic targets. Transcription treat treatment for COVID-19 variant [DOI] 10.3389/fendo.2022.971687 PMC 바로가기
Bioinformatics and systems biology approach to identify the pathogenetic link of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue SyndromeArticle Published on 2022-09-162022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome analyses analysis Analysis approach bioinformatics bioinformatics analyses biological function caused CD8A Clinical practice collected Compound condition coronavirus COVID COVID-19 infection COVID-19 pandemic CXCL8 database dataset demonstrated develop discharge enrichment analysis Evidence fatigue Genes greater healthcare help hub protein identify IL-1B IL-6 Infection information Interaction Intersection Laboratory Long Long COVID ME/CFS mechanism multicenter Myalgic encephalomyelitis/chronic fatigue syndrome network analysis nine Ontology pathway enrichment performed PPI PPI network predicted protein-protein interaction Protein–protein interaction protein–protein interaction network required SARS-CoV-2 signaling pathway Symptom syndrome Systems biology systems biology. therapeutic drug TP53 Transcription transcription factor [DOI] 10.3389/fimmu.2022.952987 PMC 바로가기
Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19Article Published on 2022-09-062022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단, [키워드] alarmin antiviral response approach binding blood leukocyte characterized COVID-19 COVID-19 pathogenesis differentially expressed down-regulation driver expression humans Immunity immunopathology JAK-STAT pathway knockout lincRNA lncRNA long noncoding RNA LUCAT1 monocyte Monocytes naïve NF-κB NF-κB-dependent gene noncoding RNA nuclear promote promoter pseudogene PU.1 Release remained RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Single-cell RNA sequencing single-cell RNA-seq single-cell RNA-seq. Stat1 suggested systemic immune response target Transcription transcription factor transcription factors transcriptional transgene viral infection [DOI] 10.1073/pnas.2120680119 PMC 바로가기
Impaired activation of transposable elements in SARS-CoV-2 infectionArticle Published on 2022-09-052022-11-15 Journal: EMBO Reports [Category] SARS, 유전자 메커니즘, 치료제, [키워드] activate activated Activation Cell cellular changes in Chromatin structure correlation COVID-19 Defense drug target element elements Epigenetic epigenetics Evidence explain expression expression level functional Genes Host host immune system identify immune Impaired Infection interferon interferon response mechanism primary cells Proteins provide regulate robust SARS-CoV-2 SARS-COV-2 infection suggested the SARS-CoV-2 Transcription transposable elements. upregulation variable viral infections Viral load viruses [DOI] 10.15252/embr.202255101 PMC 바로가기
Deciphering SARS CoV-2-associated pathways from RNA sequencing data of COVID-19-infected A549 cells and potential therapeutics using in silico methodsArticle Published on 2022-09-022022-11-16 Journal: Medicine [Category] SARS, 유전자 메커니즘, [키워드] A549 cell activated Activation acute respiratory syndrome addition Analysis Atypical candidate caused characterized CLC complications CoV COVID COVID-19 COVID-19 infection cytokine deaths DEGs Determining differentially expressed gene disease drug effective experimental validation Gene Expression Omnibus gene signatures Genomics GEO GSE147507 human-to-human transmission identify IFNβ IL-17 IL-1β Illumina in silico In silico method influenza A Interaction interferon beta interferon regulatory factor IRF3 IRF9 JQ1 knowledge mechanism Methylprednisolone mock-treated pathology pathway Pneumonia Prednisolone Quality control receptors RNA RNA sequencing RNA sequencing data SARS CoV-2 signaling pathway signaling pathways small molecule STAT2 the Coronaviridae the disease therapy Transcription Treatment underlying disease upstream Viral protein virus infection was used with COVID-19 Wuhan, China [DOI] 10.1097/MD.0000000000029554 PMC 바로가기