Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults조직 특이성 인식 TWAS(TSA-TWAS) 프레임워크는 HIV 양성 성인의 대사, 면역 및 바이러스 특성과의 새로운 연관성을 식별합니다.Research Article Published on 2021-04-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect affected AIDS Analysis applied association associations assumption Bilirubin bioinformatics CETP cholesterol cholesteryl ester clinical complex contribute current dataset enzyme eQTLs error rate evaluate experimental design expressed expression expression quantitative trait loci False positive Gene Expression Genes greater group High-density lipoprotein High-density lipoprotein cholesterol highlighting identify Laboratory loci mechanisms methodology multiple tissues novel association plasma pleiotropic gene power previous study promote Protein provide Quantitative regulated Regulatory replicated Research robust specificity statistical tissue tissues total bilirubin total bilirubin levels traits transcriptional transcriptionally transcriptome-wide transfer Triglyceride type I type I error UGT1A1 uridine uridine diphosphate variety Viral Viral load [DOI] 10.1371/journal.pgen.1009464 PMC 바로가기 [Article Type] Research Article
Unique inflammatory profile is associated with higher SARS-CoV-2 acute respiratory distress syndrome (ARDS) mortality독특한 염증 프로파일은 더 높은 SARS-CoV-2 급성 호흡 곤란 증후군(ARDS) 사망률과 관련이 있습니다.Article Published on 2021-03-012022-09-12 Journal: American Journal of Physiology - Regulatory, Integrative and Comparative Physiology [Category] MERS, SARS, 진단, [키워드] acute respiratory distress ARDS association calibrated caused chemokines circulating circulating leukocyte circulating leukocytes Complication conducted correlation COVID19 Critical Cytokines death EGF Gene Expression group had no Hyperinflammatory IL1RA IL8 Infection Inflammatory inflammatory mediator information leukocyte mechanically ventilated patient Mortality outcome pandemic Patient patients with COVID19 phenotype plasma prospective cohort study Protein RANTES regulated SARS-CoV-2 statistically significant syndrome to define transcriptionally transcriptomic unique [DOI] 10.1152/ajpregu.00324.2020 PMC 바로가기 [Article Type] Article
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunityMetabolism Published on 2021-01-132022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS, [키워드] Activation activity ADP-ribose ADP-ribosylation antiviral activity antiviral responses biosynthetic boost cellular coronavirus Coronaviruses COVID-19 decrease demonstrated DNA damage ENhance enzyme expression expression of gene gene transcription host cell induce Infection Innate immunity interferon isozyme MHV murine hepatitis virus NAD biosynthesis NADP NAMPT nicotinamide nicotinamide adenine dinucleotide (NAD) nicotinamide riboside overexpression PARP PARP10 PARP12 PARP14 PARP7 Pathways pharmacological pharmacological intervention plus-stranded RNA virus poly(ADP-ribose) polymerase polymerase post-translational modification (PTM) Protein Replication RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 transcriptionally transcriptomics up-regulate [DOI] 10.1074/jbc.RA120.015138 PMC 바로가기 [Article Type] Metabolism
The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2SARS-CoV-2와 관련된 인간 폐의 노화 전사체 및 세포 경관Article Published on 2021-01-042022-09-10 Journal: Nature Communications [Category] MERS, 유전자 메커니즘, 진단, [키워드] age airway smooth muscle alveolar Analysis basal cells Cell cells cellular change characterized contribute coronavirus coronavirus disease COVID-19 Data integration deconvolution analysis decrease dendritic cell dendritic cells dysregulated Endothelial cell endothelial cells Factor feature fibroblasts goblet cells human lung identify IGSF21 Immunogenetics in vitro lung Mitochondria Older Patient pericytes populations proportion proportions proteome reduced Replication responses reveal risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro SARS-CoV-2 proteome severe coronavirus disease severe COVID-19 severity of COVID-19 smooth muscle Stress stress responses the SARS-CoV-2 the strongest transcriptional transcriptionally Transcriptome transcriptomes viral infection [DOI] 10.1038/s41467-020-20323-9 PMC 바로가기 [Article Type] Article
Increased expression of hypoxia-induced factor 1α mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patientsResearch Article Published on 2020-12-212022-10-28 Journal: Annals of Medicine [Category] COVID-19, [키워드] blood cell bronchoalveolar Cell cells cellular cellular response characterized clinical manifestations COVID-19 COVID-19 patient COVID-19 severity Critically ill CXCL8 CXCR1 CXCR2 event events explain Express expressed expression FIVE GAPDH Genes HIF1α hypoxia immature immature myeloid cells Immunopathogenesis Increased Inflammation involved leukocyte lung cell marker metabolism molecular monocyte monocyte-macrophages Monocytes mRNA myeloid cell Neutrophils oxygen levels performed peripheral blood cells PFKFB3 PGK1 physiological response potential molecular precursors regulated Result RNAseq SARS-CoV-2 scRNAseq severe cases SLC2A3 SOD2 subset target targets therapy TLR TLR2 transcription factor transcriptional transcriptionally virus [DOI] 10.1080/07853890.2020.1858234 PMC 바로가기 [Article Type] Research Article
Baricitinib restrains the immune dysregulation in patients with severe COVID-19Clinical Trial Published on 2020-12-012022-10-05 Journal: The Journal of Clinical Investigation [Category] SARS, 임상, [키워드] anti-SARS-CoV-2 antibody antibody production approved B cell Baricitinib blood cell change circulating Clinical outcome clinically coronavirus disease correlated COVID-19 cytokine level cytokine release develop Disabled evaluated Evidence expression extreme fraction frequencies functional IL-1β IL-6 immune immune dysregulation Immune phenotype Immunity immunology increase in Inflammatory response Innate Innate immunity JAK/STAT signaling Local lymphopenia modulating myeloid cell need for oxygen off-label oxygen P/F PaO2 Pathways Patient patients treated patients with COVID-19 per day phosphorylated Pneumonia prevented progression reduction in regulated Serum level severe COVID-19 Spike protein STAT3 supported the patient the SARS-CoV-2 therapy TNF-α transcriptionally treated Trial viral disease [DOI] 10.1172/JCI141772 PMC 바로가기 [Article Type] Clinical Trial
Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor Research Published on 2020-10-192022-10-05 Journal: Nature Genetics [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome amino acids angiotensin-converting enzyme 2 atlas binding cause cellular entry Co-infection condition coronavirus COVID-19 expression full-length SARS-CoV-2 independent induce Infection Inflammatory interferon-stimulated gene ISG isoform lack outcomes promote receptor SARS-CoV-2 Spike protein susceptibility target cells the SARS-CoV-2 transcriptionally Tumor tumor microenvironment unlikely Variability virus [DOI] 10.1038/s41588-020-00731-9 [Article Type] Research
Presence of Genetic Variants Among Young Men With Severe COVID-19Case Reports Published on 2020-08-182022-10-04 Journal: JAMA [Category] MERS, 변종, [키워드] acute respiratory syndrome affected age Analysis Blood carried case sery caused Cell chronic disease Control controls coronavirus coronavirus disease COVID-19 criteria died downregulated downstream experiments exposure Final finding Follow-up functional Genetic Genetic variant hospital ICU identify IFN IFN-γ IFNB1 immune defects immunodeficiency immunological Immunological test Importance individual intensive care interferon interferon signaling IRF7 ISG15 loss-of-function male measure mechanical ventilation Medical conditions men missense variant mononuclear cell mRNA expression Netherland Netherlands objective occur one patient participant pathogenesis of COVID-19 Patient patients patients hospitalized patients with COVID-19 performed Peripheral blood Point preliminary finding Presence primary immune cell Rapid Relevance responses Result SARS-CoV-2 setting severe coronavirus disease severe COVID-19 Severe infection Signaling significantly the mean the patient TLR7 transcriptionally type I type I interferon type II IFN variant ventilatory support whole-exome sequencing [DOI] 10.1001/jama.2020.13719 PMC 바로가기 [Article Type] Case Reports
Overexpression of the nucleocapsid protein of Middle East respiratory syndrome coronavirus up-regulates CXCL10Research Articles Published on 2018-09-212022-10-28 Journal: Bioscience Reports [Category] Coronavirus, [키워드] A549 cells addition airway epithelial cell antiviral genes antiviral response cause cells cellular processe CXCL10 dendritic cells determine Factor fibroblast cells Genes high mortality rate Host Human IL6 IL8 independent infected cell Infection interactions knowledge lung MERS-CoV Middle East Middle East respiratory syndrome Coronavirus monoclonal antibody monocyte-derived macrophage motif murine N-terminal domain nucleocapsid nucleocapsid protein overexpressed overexpression Patient PCR Protein regulate regulated reported residue Respiratory disease respiratory syndrome coronavirus secretion selected Severity of disease TNF transcriptional transcriptionally transiently transfected translational up-regulate up-regulated was used [DOI] 10.1042/BSR20181059 PMC 바로가기 [Article Type] Research Articles
Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balanceH3K9 메틸화 균형을 조절하여 H3K9 탈메틸화효소 Jmjd1a 결핍 마우스의 비정상적인 성 발달 구조Research Article Published on 2017-09-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activities activity administration approach balance biological function Cancer chromatin complex core histones deficiency demethylase demonstrated Diseases DNA Embryo embryonic enzyme Epigenetic eukaryotes expression Genetic hallmark heterochromatin heterozygous histone histone methylation Histones inhibitor initiate intellectual disability leads locus lysine mammals Methylation methyltransferase mice Modification modulating modulation molecular mechanism mutant Mutation pharmacological phenotype principle proof provide rescued reveal Sex Sex determination Therapeutic strategies therapeutic strategy transcriptional regulation transcriptionally tuning [DOI] 10.1371/journal.pgen.1007034 PMC 바로가기 [Article Type] Research Article