transcriptionally – Communicable Diseases Research

An improved Fuzzy based GWO algorithm for predicting the potential host receptor of COVID-19 infection

Research article

Published on 2022-08-012022-10-05
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종,

Increased Abundance of Achromobacter xylosoxidans and Bacillus cereus in Upper Airway Transcriptionally Active Microbiome of COVID-19 Mortality Patients Indicates Role of Co-Infections in Disease Severity and Outcome

COVID-19 사망률 환자의 상부 기도에서 증가된 Achromobacter xylosoxidans 및 Bacillus cereus는 질병 심각도 및 결과에서 공동 감염의 역할을 나타냅니다.

Article

Published on 2022-06-292022-09-11
Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] abundance Achromobacter Actinomyce Alter Analysis Antibiotic therapy approaches Bacillus cereus Bacterial bacterial species bacterial specy Care clinical manifestation Co-infection complementary complications of COVID-19 contribute COVID-19 COVID-19 patient current disease disease outcome disease pathology disease severity disease sub-phenotype Exacerbation Factor feature functional groups highlight Holo-Seq hospital host-pathogen interactions Increased Inflammatory response Inflammatory responses Integrative analysis investigated involved isolate isolates Leptotrichia mechanism Medical care metabolic pathways microbe microbial Mild mild COVID-19 patients moderate modulate modulating Mortality nasopharyngeal nasopharyngeal RNA outcome parameters pathogen pathogen genomics Patient patients phenotype Phenotypes Phylogenetic analysis progression provide question recovered patient recovered patients reported respiratory virus respiratory virus oligo panel (RVOP) role SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 pathogenesis Sequencing severe COVID-19 severe disease severity susceptibility Symptoms the disease the patient transcript transcriptionally transcriptionally active microbial isolates. Transmissibility upper vaccination variants variants of concern VoC window
[DOI] 10.1128/spectrum.02311-21 PMC 바로가기 [Article Type] Article

Gene Set Enrichment Analysis Reveals That Fucoidan Induces Type I IFN Pathways in BMDC

유전자 세트 농축 분석을 통해 후코이단이 BMDC에서 I형 IFN 경로를 유도한다는 사실이 밝혀졌습니다

Article

Published on 2022-05-272022-09-11
Journal: Nutrients [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

[키워드] activate Analysis Antigen presentation Antiviral antiviral activity BMDC CD40 CD80 cytometric DEGs dendritic dendritic cell dendritic cells differentially expressed gene Differentially expressed genes differentially expressed genes (DEGs) driven by enrichment enrichment analysis Flow Flow cytometric analysis fucoidan gene set enrichment analysis gene set enrichment analysis (GSEA) greater GSEA highlighting IFN IFN-stimulated gene immune cells Inflammatory response innate immune Innate immune cells IRF ISG ISGs maturation mechanism MHCII NF-κB NLR nucleic acid pathway Pathways polysaccharide potential mechanism Prevent PRR receptor SARS-CoV-2 Signaling STAT STING sulfated surface marker TLR transcription factors transcriptional change transcriptionally Transcriptome transcriptome change treat Type type I Type I IFN type I interferon upregulated viral infections viruses
[DOI] 10.3390/nu14112242 PMC 바로가기 [Article Type] Article

A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection

새로운 글루코코르티코이드 및 안드로겐 수용체 조절제는 SARS-CoV-2 감염의 시리아 햄스터 모델에서 바이러스 진입 및 선천성 면역 염증 반응을 감소시킵니다

Immunology

Published on 2022-02-162022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료제,

[키워드] 2019-nCoV 2019-nCoV/USA-WA1/2020 ACE2 acting Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration amplify Analysis androgen Androgen receptor angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animal animals antagonist antagonists bind caused CD4 Cell clinical development Clinical studies clinical study coronavirus COVID-19 Critical days post-infection decrease Defense domain dose-dependent DPI Efficacy enzyme examined expression glucocorticoid Glucocorticoid receptor golden hamster hamster Host host defense humans IL-6 indicated infiltration Inflammation inflammatory lung injury Inflammatory response Innate innate immune Innate immunity intranasally lack lung Lung histopathology Lung injury lung tissue Macrophage macrophages mechanism mechanism of action Model modulator molecular docking studies Molecular docking study novel oral administration outcome patients Phylogenetic analysis positive Predictive Prevent progression protease Protein PT150 receptor receptors reduce regulated Replication replication of SARS-CoV-2 required Research respiratory response Result SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection sequence identity Serine serine 2 severe acute respiratory syndrome Coronavirus shown strain surface protein T-cell T-cells TCID the cell therapeutic therapeutic efficacy Therapeutics tissue damage tissue injury TMPRSS2 transcriptional repressor transcriptionally transmembrane Treatment USA-WA1/2020 variants variants of SARS-CoV-2 Viral viral entry Viral load virus were infected
[DOI] 10.3389/fimmu.2022.811430 PMC 바로가기 [Article Type] Immunology

Pulmonary Mesenchymal Stem Cells in Mild Cases of COVID-19 Are Dedicated to Proliferation; In Severe Cases, They Control Inflammation, Make Cell Dispersion, and Tissue Regeneration

Immunology

Published on 2022-01-132022-11-01
Journal: Frontiers in Immunology [Category] COVID-19,

[키워드] “cytokine storm” affected Alter Analysis biological function bronchoalveolar lavage sample CD40 Cell cell proliferation Cell therapy cell types chemotaxis clinical conditions Control COVID-19 COVID-19 patient Cytokine storm cytoplasmic Data analysis dispersion FHL2 Genes IFNGR1 IFNGR2 immune individual individuals induce inhibitor involved lung marker MDA5 mesenchymal stem cell Mild mild case mild COVID-19 patients MSC MSCs Necrosis NF-κB NFKBIA not express OPTN overexpression paracrine Patient performed PKR PPP2CB promote inflammation pulmonary receptors regeneration RNA secretion sequence Severe case severe COVID-19 single cell RNA sequencing single-cell RNA-seq STEM stem cell Target genes therapeutic therapeutic potential therapy for COVID-19 these cell tissue tlr-3 TLRs TNFR1 TNFR2 Transcription transcriptionally treat triggered upregulated upregulated gene upstream virus virus load
[DOI] 10.3389/fimmu.2021.780900 PMC 바로가기 [Article Type] Immunology

Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021

Reviews

Published on 2021-12-012022-10-05
Journal: Nature Medicine [Category] 바이오마커, 비임상, 치료제,

SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis

SARS-CoV-2는 STAT1-IRF1-NLRC5 축을 표적으로 하여 MHC 클래스 I 경로의 유도를 억제합니다

Article

Published on 2021-11-152022-09-10
Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료제,

Differential dynamics of peripheral immune responses to acute SARS-CoV-2 infection in older adults

Research

Published on 2021-10-282022-10-05
Journal: Nature Aging [Category] SARS, 임상,

COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1 + neutrophils and CD14 + monocytes

COVID-19와 RA는 PD-L1 + 호중구 및 CD14 + 단핵구를 구동하는 SPP1 골수성 경로를 공유합니다

Research Article

Published on 2021-06-182022-09-10
Journal: JCI Insight [Category] MERS, 바이오마커,

[키워드] Activation alveoli appear Arthritis Autoimmune diseases BALF Bronchoalveolar lavage fluid cause CD14 CD48 Chronic inflammatory arthritis Cluster Concentration COVID-19 COVID-19 pathogenesis disease driven by FABP4 FCN1 hallmark healthy high plasma levels IHC Infectious disease Inflammation innate response intensive care unit investigation lung Macrophage macrophage cluster macrophage clusters macrophages mechanism mediators monocyte Monocytes myeloid cell neutrophil Neutrophils pathogenic pathology pathway PD-L1 plasma plasma concentrations Pneumonitis predicted Predictive predominant proinflammatory remained rheumatoid arthritis S100A12 severe COVID-19 severe pneumonia SPP1 synovial synovitis tissue trajectory transcriptionally transfer TREM2 unique upstream
[DOI] 10.1172/jci.insight.147413 PMC 바로가기 [Article Type] Research Article

Generation of WAe001-A-58 human embryonic stem cell line with inducible expression of the SARS-CoV-2 nucleocapsid protein

SARS-CoV-2 뉴클레오캡시드 단백질의 유도성 발현을 갖는 WAe001-A-58 인간 배아 줄기 세포주의 생성

Article

Published on 2021-05-012022-09-11
Journal: Stem cell research [Category] SARS, 치료법,