SARS-CoV-2 Achieves Immune Escape by Destroying Mitochondrial Quality: Comprehensive Analysis of the Cellular Landscapes of Lung and Blood Specimens From Patients With COVID-19SARS-CoV-2, 미토콘드리아 품질을 파괴하여 면역 탈출 달성: COVID-19 환자의 폐 및 혈액 표본의 세포 환경에 대한 종합 분석Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated activating alveolar alveolar epithelial cell alveolar epithelial cells alveolar macrophage Alveolar macrophages analyzed antiviral immunity B cell B cells blocked Blood calcium cell count Comprehensive coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients crossfire cytokine Cytokine storm dataset Defense Degradation energy metabolism epithelial epithelial cell epithelial cells escape exacerbated excessive inflammation explain expression Gene Expression HIF1a Host IFI27 immune immune cells Immune escape Inflammation inhibited Interaction interferon landscape lung tissue Lungs Macrophage macrophages manifestation MCU metabolic pathway metabolism Mitochondria mitochondrial mitochondrial fission mitochondrial functions mitochondrial quality. pathway patients with COVID-19 Perspective plasma pro-inflammatory Regulatory T cell regulatory T cells released Replication respiratory capacity resulting RNA-sequencing SARS-CoV-2 significant changes in Single-cell RNA-sequencing T cells target transformation Tregs type I viral infection [DOI] 10.3389/fimmu.2022.946731 PMC 바로가기 [Article Type] Article
Assessment of CD39 expression in regulatory T-cell subsets by disease severity in adult and juvenile COVID-19 casesArticle Published on 2022-05-012023-06-20 Journal: Journal of medical virology [Category] Fulltext, MERS, [키워드] CD39 COVID-19 FOXP3 Infectious diseases Tregs [DOI] 10.1002/jmv.27593 PMC 바로가기
The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19Review article Published on 2022-04-012022-10-05 Journal: Life sciences [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 Affect cardiac damage cardiovascular cardiovascular complication cardiovascular complications Cardiovascular function cause Cell cells cellular chemokine Comorbidity contribute coronavirus COVID-19 COVID-19 pathogenesis COVID-19 patients Cytokine storm disorder evaluated expressed fibroblasts function immune Immune cell immunological mechanism IMPROVE infect Inflammation Inflammatory cytokine Inflammatory responses macrophages mechanism mechanisms molecular Monocytes Patient pericytes reducing regulate Regulatory T cell Research risk SARS Coronavirus SARS CoV-2 severe COVID-19 subset suppress T cell target cell therapeutic potential These cells Treatment Treg Tregs variety viral infection [DOI] 10.1016/j.lfs.2022.120392 [Article Type] Review article
Persistent Overactive Cytotoxic Immune Response in a Spanish Cohort of Individuals With Long-COVID: Identification of Diagnostic Biomarkers장기간 코로나바이러스를 가진 개인의 스페인 코호트에서 지속되는 과민성 세포독성 면역 반응: 진단 바이오마커의 식별Article Published on 2022-03-252022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] Accuracy Algorithm analyzed Antiviral Autoimmune disease Blood blood type caused CD3 CD4 CD56 CD57 CD8 CD8+ CD8+ T cells cells characterized chest pain clinical feature Clinical management Cohort cytotoxic cytotoxic activity cytotoxic immune response Definition demographic factor Demographic factors detect diagnostic biomarker Diagnostic biomarkers expression female gender forest functional hypotheses identification immune immune exhaustion. immune parameter immunological parameter immunological parameters IMPROVE individual Infection Inflammatory response lethargy Long long-COVID long-lasting Lymphocytes marker mechanism memory cell Memory cells NK cell NK cells organ participant patients PD-1 persistence persistent phenotype pleuritic Population Post-infection predicted Random forest Random Forest algorithm recovered completely response SARS-CoV-2 significantly increased Signs and symptoms Spanish supported sustained Symptom symptoms of COVID-19 syndrome T cells T lymphocytes Temra cells tissue Treg Tregs [DOI] 10.3389/fimmu.2022.848886 PMC 바로가기 [Article Type] Article
Low Levels of Granulocytic Myeloid-Derived Suppressor Cells May Be a Good Marker of Survival in the Follow-Up of Patients With Severe COVID-19낮은 수준의 과립구 골수 유래 억제 세포는 중증 COVID-19 환자의 추적 관찰에서 생존의 좋은 지표가 될 수 있습니다Observational Study Published on 2022-01-282022-09-12 Journal: Frontiers in Immunology [Category] 임상, 진단, [키워드] activated acute respiratory syndrome association cause Cell cells circulating contribute coronavirus coronavirus disease COVID-19 COVID-19 patients death develop died discharge discharged disease Endpoint Evolution examined Follow-up Good Granulocytic ICU immunological Immunosuppression Increased Infection inhibitory intensive care Level lymphocyte Lymphocytes MDSCs Mortality OX40 Pathogenesis Patient patients Patients with cancer PD-1 question raised SARS-CoV-2 SARS-CoV2 severe COVID-19 suppressor Tregs two group [DOI] 10.3389/fimmu.2021.801410 PMC 바로가기 [Article Type] Observational Study
A Novel Prognostic Signature for Survival Prediction and Immune Implication Based on SARS-CoV-2–Related Genes in Kidney Renal Clear Cell CarcinomaBioengineering and Biotechnology Published on 2022-01-242022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] ACADM Accuracy Analysis applicability carcinoma caused Cell CENPF cohorts correlation COVID-19 CTLA-4 dataset enrichment analysis exhibit expand expressed gene expression follicular General population Genes global public health GSEA higher risk immune Immune cell indicated investigated kidney renal clear cell carcinoma LAG-3 Macrophage malignancy nomogram novel pathway Patient patients PDCD1 PLOD2 potential therapeutic target prediction Predictive predictor prognostic prognostic signature proportion provided Regulatory T cell renal reported SARS-CoV-2 SARS-COV-2 infection serious complication severe disease signature significantly survival TIGIT tissues Tregs TRMT1 urinary system [DOI] 10.3389/fbioe.2021.744659 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
Regulatory T cells in COVID-19Commentary Published on 2021-10-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] acute respiratory syndrome Affect alleviate caused coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated disease Disease progression exacerbated highlight immune response immune responses immune system immunosuppressive effects Infection Inflammation Inflammatory multiple organ dysfunction outbreak Perspective prevalent recent recent finding reduced reduction Regulation Regulatory T cell regulatory T cells Respiratory failure risk SARS-CoV-2 significantly subpopulation Symptom syndrome T cell therapy Treg Tregs [DOI] 10.14336/AD.2021.0709 PMC 바로가기 [Article Type] Commentary
Asymptomatic and Mild SARS-CoV-2 Infections Elicit Lower Immune Activation and Higher Specific Neutralizing Antibodies in Children Than in Adults무증상 및 경증의 SARS-CoV-2 감염은 성인보다 어린이의 면역 활성화를 낮추고 특정 중화 항체를 더 많이 유발합니다Immunology Published on 2021-09-302022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults age analyzed anti-SARS-CoV-2 antibody baseline blood sample Blood samples Breg children Clinical outcome contribute coronavirus coronavirus disease Coronavirus disease 2019 correlated CoV COVID-19 COVID-19 children COVID-19 group COVID-19 patient COVID-19 patients enrolled Exhaustion expression first positive flow cytometry greater immune activation Immune profile immune response Infection interquartile investigated Lower median NAb NAbs Nasopharyngeal swab nasopharyngeal swabs neutralization test Neutralizing antibodies neutralizing antibodies (NAbs) Non-COVID-19 not differ Patient PCR pediatric plaque reduction neutralization Plaque reduction neutralization test positively correlated quantified reduce regulatory cell regulatory cells respiratory Result SARS-CoV-2 senescence senescent cell serology severe acute respiratory syndrome Coronavirus Specific subjects symptom onset Treg Tregs Tregs and Bregs Viral Viral load virus virus detection [DOI] 10.3389/fimmu.2021.741796 PMC 바로가기 [Article Type] Immunology
Profound Treg perturbations correlate with COVID-19 severity420 Published on 2021-09-142022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] Antiviral Complication contribute Convalescent patients COVID-19 COVID-19 pathology detrimental dysfunction effectors excessive inflammation expression FOXP3 hallmark IL-18 IL-6 Immune homeostasis immunological increase in Inflammatory response MOST notable outcomes overexpression Patient Perturbation perturbations phenotype poor prognosis proinflammatory proinflammatory mediators proinflammatory molecule proportion proportions Regulatory T cell responses responsible resulting severe COVID-19 severe COVID-19 patients severe disease Severe patient severity Significance similarity suppress T cell response T regulatory cell the disease these cell transcription factor transcriptional transcriptomic Treg Tregs tumor Tregs with COVID-19 [DOI] 10.1073/pnas.2111315118 PMC 바로가기 [Article Type] 420
Cutaneous Adverse Reactions to COVID-19 Vaccines: Insights from an Immuno-Dermatological PerspectiveReview Published on 2021-08-252022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] ADR ADRS Adverse Adverse drug reaction adverse event approval arising clinical development concerning coronavirus disease Course COVID-19 COVID-19 vaccines Cutaneous cytokine profile determine Efficacy Exanthema group immunogenic reaction Inflammatory injection site insight natural infection Numerous occur outcome Patient patients performed profiles reached reaction required Research SARS-CoV-2 Side effect Specific subset T-cell Th1 Th2 Tregs type I interferons Vaccine Vaccines [DOI] 10.3390/vaccines9090944 PMC 바로가기 [Article Type] Review