SARS-CoV-2 N Protein Targets TRIM25-Mediated RIG-I Activation to Suppress Innate ImmunitySARS-COV-2 N 단백질은 타고난 면역을 억제하기 위해 TRIM25- 매개 RIG-I 활성화를 표적으로합니다.Article Published on 2021-07-232022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, 치료법, [키워드] accessory proteins Activation Affect affecting antagonistic characterized clinical picture contributing to counteract COVID-19 Cytokines decrease demonstrated domain ENCODE exacerbated expressed feature host immune system IFN Infection Innate innate immune response Innate immunity Interaction involved Mask mechanism molecular mechanism molecular mechanisms N protein novel SARS-CoV-2 virus occurred Pathways Pattern recognition pattern recognition receptor pro-inflammatory cytokine pro-inflammatory cytokines Protein PRR Recognition reported RIG-I RIG-I activation SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein SARS-CoV-2 virus secretion signaling pathways suppresse target the N protein the SARS-CoV-2 TRIM25 Viral viral pathogenesis [DOI] 10.3390/v13081439 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 RNA interactomeSARS-CoV-2 RNA 상호작용체Article Published on 2021-07-012022-09-11 Journal: Molecular Cell [Category] SARS, 유전자 메커니즘, [키워드] Analysis Antiviral Applying conserved Coronaviral coronavirus COVID-19 CSDE1 develop downstream EIF3D evade experiment Factor HCoV HCoV-OC43 Host host proteins identify interact Interaction knockdown LARP1 life cycle mass spectrometry mRNA mTOR mTOR signaling OC43 PARP12 pathogen pathway Protein protocol provide Replication responsible ribonucleoprotein RNA RNA interactome capture RNA virus RNA-binding proteins RNAs robust SARS-CoV-2 SARS-CoV-2 RNA SHFL the SARS-CoV-2 therapeutic interventions Transcriptome TRIM25 virus ZC3HAV1 [DOI] 10.1016/j.molcel.2021.04.022 PMC 바로가기 [Article Type] Article
Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection비교 전 사체 분석은 SARS-CoV-2 감염의 주요 후성 유전 적 표적을 나타냅니다Article Published on 2021-05-242022-09-10 Journal: NPJ Systems Biology and Applications [Category] SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome coronavirus 2 Analysis analyzed Candidates caused cell line cell lines change Comparative coronavirus COVID-19 current described effort EP300 Epigenetic Factor feasible gene co-expression network host cell host cell response Infection involved MERS MERS-CoV molecular mechanism molecular mechanisms MOV10 outbreak pathway pathway enrichment Protein Regulation Regulatory networks RELA Research respiratory respiratory syndrome coronavirus 2 reveal SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Systems analysis target therapeutic options therapeutic potential transcription factors Transcriptional changes Transcriptome transcriptomes treat TRIM25 Viral viral infection [DOI] 10.1038/s41540-021-00181-x PMC 바로가기 [Article Type] Article
LncRNA XIST upregulates TRIM25 via negatively regulating miR-192 in hepatitis B virus-related hepatocellular carcinomaResearch Article Published on 2021-04-152023-06-03 Journal: Molecular Medicine [Category] B형 간염, [키워드] Hepatocellular carcinoma human hepatitis B virus lncRNA XIST miR-192 TRIM25 [DOI] 10.1186/s10020-021-00278-3 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon ResponseArticle Published on 2021-03-022022-10-06 Journal: Cells [Category] SARS, 진단, [키워드] acute respiratory syndrome antiviral drug antiviral immune response antiviral immunity association characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Gene Expression Host IFN IFN signaling induction Influenza virus inhibited Interaction interferon interferon regulatory factor IRF3 lack modulating molecular motif N protein nonstructural protein 1 nuclear translocation nucleocapsid protein pandemic pathogenesis of SARS-CoV-2 Protein response RIG-I RIG-I like receptors SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein suppressed target TBK1 the SARS-CoV-2 TRIM25 type I urgency Zika virus [DOI] 10.3390/cells10030530 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in HumansResearch Article Published on 2020-10-162022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Analysis Antiviral bat bat coronaviruses cofactor Comprehensive conserved coronavirus coronavirus disease COVID-19 CpG CpG suppression defined dinucleotide effective effector Efficiency Environment evaluated Evidence Evolution experiment expressed expression expression levels finger genomic greater Host Human human coronaviruses human lung cells humans I, II IFN IFN-α IFN-γ IFNs immune in viral inhibit SARS-CoV-2 inhibited innate response interferon isoform KHNYN lowest orthologue orthologues pandemic pathogen promote Protein recent reduced restrict Restricted RNA sequences SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA sequence significantly suppressed target the SARS-CoV-2 genome therapy Treatment TRIM25 Type viral pathogen ZAP Zinc zoonosis [DOI] 10.1128/mBio.01930-20 PMC 바로가기 [Article Type] Research Article
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-IArticle Published on 2020-01-242023-06-24 Journal: The Journal of Biological Chemistry [Category] 신종인플루엔자, [키워드] 1918 H1N1 Host–pathogen interaction Infectious disease Influenza Innate immunity non-structural protein 1 NS1 nuclear magnetic resonance (NMR) RIG-I TRIM25 Viral protein [DOI] 10.1074/jbc.RA119.011410 PMC 바로가기