Reciprocal regulation of lncRNA MEF and c-Myc drives colorectal cancer tumorigenesisOriginal Research Published on 2024-02-012024-09-05 Journal: Neoplasia (New York, N.Y.) [Category] update2024, [키워드] c-MYC Colorectal cancer hnRNPK lncRNA-MEF TRIM25 [DOI] 10.1016/j.neo.2024.100971 PMC 바로가기 [Article Type] Original Research
SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon inductionOriginal Article Published on 2023-11-202024-09-05 Journal: Cellular and Molecular Life Sciences [Category] update2024, [키워드] ORF6 RIG-I SARS-CoV-2 TRIM25 Type-I IFN ubiquitination [DOI] 10.1007/s00018-023-05011-3 PMC 바로가기 [Article Type] Original Article
Interleukin-22 facilitates the interferon-λ-mediated production of tripartite motif protein 25 to inhibit replication of duck viral hepatitis A virus type 1article Published on 2023-06-302024-09-05 Journal: Veterinary Research [Category] update2024, [키워드] IFN-λ IL-22 Phosphorylation STAT3 TRIM25 [DOI] 10.1186/s13567-023-01188-4 PMC 바로가기 [Article Type] article
New Avenues to Explore in SARS-CoV-2 Infection: Both TRIM25 and TRIM56 Positively Correlate with VEGF, GAS6, and sAXL in COVID-19 PatientsArticle Published on 2022-12-012023-07-10 Journal: Viral immunology [Category] COVID19(2023년), [키워드] GAS6 HIF-1α sAXL. TRIM25 TRIM56 VEGF [DOI] 10.1089/vim.2022.0112
Avian Influenza NS1 Proteins Inhibit Human, but Not Duck, RIG-I Ubiquitination and Interferon SignalingArticle Published on 2022-09-282023-06-22 Journal: Journal of Virology [Category] 조류인플루엔자, [키워드] avian viruses Cell signaling duck influenza viruses interferons Reservoir host TRIM25 ubiquitination viral pathogenesis [DOI] 10.1128/jvi.00776-22 PMC 바로가기
Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19Covid-19의 처리를위한 유비 퀴 틸화 및 이슬 화 기계를 표적으로Review Published on 2022-02-122022-09-10 Journal: Biomolecules [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, [키워드] A20 Activation avoidance COVID-19 CYLD effective enzyme Enzymes event highlight host defense host defense response host immune system host–pathogen interactions involved ISG15 ISGylation pathway Pattern recognition pattern recognition receptor PLPro post-translational modification protease Protein PRRs PTMs SARS-CoV-2 targeting the disease therapeutic intervention Treatment TRIM25 ubiquitin ubiquitin proteasome system ubiquitomics USP18 vaccine-resistant variant Viral viral replication virus viruses [DOI] 10.3390/biom12020300 PMC 바로가기 [Article Type] Review
Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart심장 SARS-CoV-2 감염은 심장 내 전염증성 전사체 변화와 관련이 있습니다Article Published on 2022-01-292022-09-11 Journal: Cardiovascular Research [Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] adverse outcome Analysis Atla Autopsy cardiac Cardiac infection Cardiac signature matrix caused cDNA Cell consequence COVID-19 Cytometry Deceased DEGs destruction Diagnosis differentially expressed gene downregulated Effects endothelial Endothelial cell endothelial cells fraction Gene ontology GO term heart heart tissue ICAM1 identify IFI44L Immune cell Immune cell infiltration immune response Immunofluorescent staining immunohistochemistry In situ hybridization Increased Infection interferon interferon pathway investigated MACE marker massive molecular MYPN no difference NPPB paracrine Pathomechanism positive pro-inflammatory pro-inflammatory gene expression q-value Quantitative reveal RNA-Seq RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus sequencing data signature matrix single-cell dataset staining tissue transcriptomic alteration TRIM25 upregulated Viral Viral protein virus virus load was performed while [DOI] 10.1093/cvr/cvab322 PMC 바로가기 [Article Type] Article
S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategiesResearch Article Published on 2021-10-252022-10-29 Journal: PLoS Pathogens [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Antiviral antiviral activity assist association binding broad inhibitor C-terminal C-terminal region catalytic site catalytically caused cofactor complex coronavirus CpG cysteine cytoplasm Degradation dependent on determinant dinucleotide distribution domain element Endoplasmic reticulum Factors highlight HIV-1 Human immunodeficiency virus hydrophobic in viral inactive Interaction isoform KHNYN lack membrane membranes Microscopy modulate motif N-terminal RNA-binding domain nucleus PARP physical plasma membrane polymerase post-translational modification Prevent Protein provide recruitment regulate replicate Replication required residue restored RNA RNA virus RNAs SARS-CoV-2 Structure subcellular translation TRIM25 type I Vesicle viral pathogens Viral RNA virion virus virus replication ZAP [DOI] 10.1371/journal.ppat.1009726 PMC 바로가기 [Article Type] Research Article
Interactome Analysis of the Nucleocapsid Protein of SARS-CoV-2 VirusArticle Published on 2021-09-082022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Affinity purification Analysis antiviral strategy binding biogenesis calu-3 cells caused cellular complex damaged EIF2AK2 functions G3BP1 global pandemic HEK293T human cell human cells Infection interaction partner interactome MOV10 multifunctional N protein nucleocapsid protein Pathogenesis Protein public health responses ribonucleocapsid ribonucleoprotein ribosome biogenesis RNA SARS-CoV-2 SARS-COV-2 infection small subunit the N protein the SARS-CoV-2 Transcription translation TRIM25 viral genome replication viral–host interactome virus ZC3HAV1 ZCCHC3 [DOI] 10.3390/pathogens10091155 PMC 바로가기 [Article Type] Article
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response선천성 면역 반응을 조절하는 SARS-CoV-2 뉴클레오캡시드 단백질의 이중 역할Article Published on 2021-09-012022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료법, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 causative agent contribute coronavirus COVID-19 Cytokines demonstrated early stage effective strategy global pandemic High-dose IFN-I IFN-I signaling immune response immune responses Immunosuppression Infection Inflammatory cytokines innate immune response innate immune responses Innate immunity IRF3 late stage low-dose mechanism N protein nuclear translocation nucleocapsid overactive Pathogenesis pathogenesis of SARS-CoV-2 Phosphorylation promoted Protein regulated Regulatory respiratory retinoic acid retinoic acid-inducible gene I RIG-I SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid SARS-like coronaviruses severe acute respiratory syndrome Coronavirus Signaling Stat1 STAT2 suppress suppressed the SARS-CoV-2 Trigger TRIM25 type I interferon [DOI] 10.1038/s41392-021-00742-w PMC 바로가기 [Article Type] Article