SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus InfectionReview Published on 2021-08-122022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 addition binding site boost codon codon 72 polymorphism of p53 CRISPR downstream element entry receptor Gene Expression global scientific community host cells Human IFNβ inhibiting Innate innate immune response Innate immunity interferon ISGF3 complex ISRE JAK/STAT signaling pathway mortality rate MOST p53 PARP1 promoter promoter region regulate response restrict role Safe SARS-CoV-2 serine protease TMPRSS2 Signaling Single nucleotide polymorphism (SNP) SNP Stat1 STAT2 target therapy TLRs (toll-like receptors) TMPRSS2 Transcription transcriptional level TSS Type I IFN understanding virus entry virus infection [DOI] 10.3390/ijms22168660 PMC 바로가기 [Article Type] Review
Multisystem inflammatory syndrome (MIS-C) in Pakistani children: A description of the phenotypes and comparison with historical cohorts of children with Kawasaki disease and myocarditisResearch Article Published on 2021-06-212022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] Administered Atypical children clinical feature Cohort cohorts criteria CRP determine diagnosed dysfunction echocardiography eight expired feature FIVE Inflammatory interquartile range Intravenous immunoglobulin Karachi Kawasaki disease laboratory feature left less lymphopenia median age MIS-C moderate Mortality myocarditis objective outcome outcomes pandemic Patient patients phenotype presenting Result steroid syndrome tertiary care center TSS World Health Organization [DOI] 10.1371/journal.pone.0253625 PMC 바로가기 [Article Type] Research Article
A Case of COVID-19 Mimicking Acute Appendicitis in Multi-System Inflammatory SyndromePediatrics Published on 2021-06-112022-10-31 Journal: Cureus [Category] COVID-19, [키워드] abdominal pain addition Adults Affect African American age Anemia Antibiotics BNP Brain children Course COVID-19 criteria diagnose diagnosed discharge Educating effective elevated female Fever headache healthy hypercoagulability immune system Immunoglobulin implication increasingly individual Inflammation Inflammatory Inflammatory marker inflammatory markers initial Kawasaki disease Kikuchi disease macrophage activation syndrome mechanical ventilation Methylprednisolone MIS-C multi-system inflammatory syndrome in children (mis-c) organ systems pathologic peptide positive preventative measure returned SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test Shock Symptoms syndrome systemic lupus erythematosus the patient treat Treatment TSS unique urinary tract infection UTI vasopressors virus [DOI] 10.7759/cureus.15600 PMC 바로가기 [Article Type] Pediatrics
Chest Computed Tomography (CT) as a Predictor of Clinical Course in Coronavirus Disease코로나바이러스 질병의 임상 경과 예측인자로서의 흉부 컴퓨터 단층촬영(CT)Article Published on 2021-06-032022-09-11 Journal: Medical science monitor : international medical jo [Category] SARS, 치료기술, [키워드] air bronchogram Air bubble analyzed bronchiolectasis bronchogram change character Chest CT chest imaging clinical Clinical data conducted consolidations correlation Course COVID-19 patients CT scan CT scans Diagnosis diagnostic discharged patient discharged patients disease course disease severity dominant Ground-glass opacities group Halo Halo sign Hospitalization Hospitalized imaging modality Infection infections interior Łańcut lesions lung Lung CT Lymphadenopathy non-survivor Non-survivors Occurrence Patient patients with SARS-CoV-2 pleural effusion pleural thickening Poland positive correlation Prognosis prognostic Prognostic value pulmonary lesion pulmonary lesions radiological feature retrospective retrospective review rRT-PCR SARS-COV-2 infection semi-quantitative severity statistically significant difference subpleural subsegmental the disease TSS utility vessel Warsaw was used [DOI] 10.12659/MSM.931285 PMC 바로가기 [Article Type] Article
Proposal to protect patients and healthcare professionals undergoing elective surgery during COVID-19 outbreakResearch Published on 2021-04-062022-10-31 Journal: The Egyptian Journal of Radiology and Nuclear Medicine [Category] COVID-19, [키워드] addition average calculated Characteristics Chest Chest CT chest CT scan collected complementary Computerized tomography correlated correlation COVID-19 COVID-19 disease COVID-19 outbreak demographic diagnosis of COVID-19 diagnostic Diagnostic method discharge Elective surgery follow-up time Health Healthcare professional hospital Hospital stay Hospitalized information Intensive lung negative RT-PCR pandemic Patient postoperative professional PROTECT reliability Reporting Result RT-PCR RT-PCR testing Safe score Society System the patient Total TSS undergo vital status [DOI] 10.1186/s43055-021-00478-1 PMC 바로가기 [Article Type] Research
Gene signature and immune cell profiling by high-dimensional, single-cell analysis in COVID-19 patients, presenting Low T3 syndrome and coexistent hematological malignanciesResearch Published on 2021-04-012022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, MERS, [키워드] acute phase addition Analysis analyzed approach CD3+ CD38 CD4+ CD79B CD8+ T cells change clinical disease Coagulation coexistent consecutive patients coronavirus disease (COVID-19) correlated correlation count COVID-19 COVID-19 patient COVID-19 patients Critical CyTOF cytokine Cytometry demonstrated Differentially expressed genes disease effector memory expressed expression First wave Gene expression profiling group Hematological malignancies Hematological malignancy Hospitalized Host immune response IFIT3 IL-6 Immune cell immune response indicate Inflammation intensive care unit involved IP-10 leukemia LIPI Low T3 syndrome marker mononuclear cell multiplex NanoString NLR NLRP3 outbreak Patient patients with COVID-19 PBMC performed Peripheral blood Pneumonia presenting radiologic reduced reduction reported Result Rome SARS-CoV-2 serum Serum level serum levels severe COVID-19 severity single-cell SOFA subtype supplementary material syndrome T lymphocytes target gene the disease thyroid function tissue damage TSS university [DOI] 10.1186/s12967-021-02805-6 PMC 바로가기 [Article Type] Research
Trends over Time of Lung Function and Radiological Abnormalities in COVID-19 Pneumonia: A Prospective, Observational, Cohort StudyArticle Published on 2021-03-022022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95%CI abnormality acute phase Admission age alveolar volume blood gas analysis calculated Chest computed tomography Chest CT cohort study consolidation COVID-19 D-dimer diffusion capacity DLCO function functional Gas exchange Hospitalization Italy lung lung diffusion Lung function males PaO parameter Patient patients with COVID-19 physiological Pneumonia predicted Prospective Radiologists repeated severity spirometry survivor the disease time trend TSS university ventilatory [DOI] 10.3390/jcm10051021 PMC 바로가기 [Article Type] Article
Chest CT features associated with the clinical characteristics of patients with COVID-19 pneumonia코로나19 폐렴 환자의 임상적 특징과 관련된 흉부 CT 특징Research Article Published on 2021-01-102022-09-01 Journal: Annals of Medicine [Category] 진단, [키워드] abnormality age bilateral lung Chest CT Clinical characteristics clinical manifestation Computed tomography consolidation coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients diagnosing enrolled feature Follow-up GGO Ground-glass opacities ground-glass opacity help initial lesion less lung men MONITOR Next-generation sequencing nodule nodules objective outcome Patient patients with COVID-19 Pneumonia predict predominant Prognosis Result RT-PCR SARS-CoV-2 imaging features Severe case severe cases severity significantly lower Stage TSS with COVID-19 women [DOI] 10.1080/07853890.2020.1851044 PMC 바로가기 [Article Type] Research Article
Case Report: Case Series of Children With Multisystem Inflammatory Syndrome Following SARS-CoV-2 Infection in SwitzerlandPediatrics Published on 2021-01-052022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] addition Anakinra anti-IL6 Anti-inflammatory benefit case sery Child children clinical feature Cohort country cytokine profile Cytokine storm defined dose Evidence Evolution Hyperinflammatory IL-1 IL-1ra IL-6 IL-6 blocking Immunoglobulin immunomodulator Incomplete Inflammatory Intravenous immunoglobulin Laboratory medication MIS-C one patient overlap pandemic Patient presenting recent reported SARS-CoV-2 SARS-CoV2 Serum level Sery severe SARS-CoV-2 steroid steroid treatment Switzerland syndrome tested therapy toxic TSS [DOI] 10.3389/fped.2020.594127 PMC 바로가기 [Article Type] Pediatrics
Relationship of the cycle threshold values of SARS-CoV-2 polymerase chain reaction and total severity score of computerized tomography in patients with COVID 19코로나19 환자의 SARS-CoV-2 중합효소연쇄반응 주기역치와 전산화단층촬영의 총 중증도 점수의 관계Article Published on 2020-12-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, 치료제, [키워드] acute lung inflammation age both groups buffer calculated Care Chain Reaction changes Chest Chest CT Chest tomography Computerized tomography contagious COVID 19 COVID-19 COVID-19 patient COVID-19 patients Critical Ct value Ct values cycle threshold Cycle threshold value died early stage early stages evaluate evaluated Factor FIVE help Hospitalization Hospitalized hospitalized patients identify in both groups lung lobes median age Medical care Mortality Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples nasopharynx nucleic acid older patient older patients Outpatient outpatients Patient patients performed polymerase chain polymerase chain reaction primer Primers probe probes quantified ranged RdRP RdRp gene relationship reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR RT-PCR test RT-PCR tests SARS-CoV-2 SARS-CoV-2 RNA severity significantly higher Spread Total Total severity score transcriptase TSS Turkey Viral Viral load viral nucleic acid virus was related [DOI] 10.1016/j.ijid.2020.09.1449 PMC 바로가기 [Article Type] Article