sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 ActivitySTREM-1은 COVID-19 환자의 질병 중증도 및 사망률을 예측합니다 : 말초 혈액 백혈구 및 MMP-8 활동의 관여Article Published on 2021-12-152022-08-31 Journal: Viruses [Category] SARS, 바이오마커, [키워드] activity Biomarker Characteristics clinical Clinical data coronavirus coronavirus disease correlated COVID-19 COVID-19 positive patient Critical death disease enrolled evaluated expressed expression groups IL-10 IL-6 IL-8 immunoassays indicated Inflammation inflammatory mediator inflammatory parameters Inflammatory response inflammatory signals intrinsic investigated Involvement lymphocyte lymphocyte counts matrix metalloproteinase matrix metalloproteinases mediator medical records Mild MMP-8 moderate Mortality MOST myeloid cells myeloid cells-1 neutrophil neutrophil counts outcome Patient patients with COVID-19 peripheral Peripheral blood peripheral blood cells pharmacological intervention pharmacological interventions plasma Plasma level Plasma levels positive correlation positive patients Predictive profile quantification severe disease severity severity of COVID-19 significant negative correlation significantly significantly higher sTREM-1 systemic the timing uncontrolled was related [DOI] 10.3390/v13122521 PMC 바로가기 [Article Type] Article
Emerging cases of mucormycosis under COVID-19 pandemic in India: Misuse of antibioticsObservational Study Published on 2021-11-012022-10-05 Journal: Drug development research [Category] 임상, [키워드] accounted addition Antibiotics Black fungus caused corticosteroid treatment COVID-19 COVID-19 case COVID-19 pandemic deaths Diabetic disease dropped drug First wave fungal Fungal infection glucocorticoid High dose Hypoxemia immune immunosuppressive India maintain Mild misuse Mucormycosis neutropenia pathway poor prognosis recorded reported risk factor SARS-CoV-2 second wave Spread stability Steroids Tocilizumab treated uncontrolled [DOI] 10.1002/ddr.21862 PMC 바로가기 [Article Type] Observational Study
Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice마우스에서 SARS-CoV-2 발병에 대한 렘데시비르의 경구 뉴클레오시드 유사체의 치료 효능Article Published on 2021-09-172022-09-11 Journal: bioRxiv [Category] 비임상, [키워드] administration Antiviral antiviral activity antivirals Breakthrough infection breakthrough infections breath conserved COVID-19 COVID-19 pandemic Culture develop dose-dependent drug effective Efficacy exhibited exploration GS-441524 human clinical trial humans IMPROVE in vitro in vivo increasingly infected with SARS-CoV-2 Infection lung cell lung cell line lung cell lines Lung pathology mice molnupiravir monoclonal antibodies monoclonal antibody nucleoside oral administration outcome outpatients parental pharmacokinetic Pulmonary function reduced Remdesivir RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants significantly Support target therapeutic therapeutic efficacy therapy These data translated Treatment uncontrolled vaccination Viral load Viral protein Viral proteins waning immunity [DOI] 10.1101/2021.09.13.460111 PMC 바로가기 [Article Type] Article
ECMM/ISHAM recommendations for clinical management of COVID-19 associated mucormycosis in low- and middle-income countries저소득 및 중간 소득 국가에서 COVID-19 관련 점막 진균증의 임상 관리를 위한 ECMM/ISHAM 권장 사항Article Published on 2021-09-012022-09-12 Journal: Mycoses [Category] SARS, 진단, [키워드] animal antifungal therapy Care Clinical management clinician Corticosteroid corticosteroid therapy Corticosteroids country COVID-19 COVID-19 patient diabetes Diabetes Mellitus diagnosing Diagnosis disease Endothelial cell Epidemic European Factor Factors Glucose glycaemic control GRP help High dose Human immunosuppressive Immunotherapy increased expression India indicated Infection management Misconception Mucorale Mucorales Mucormycosis mycology occur Protein provide recommendation regulated report SARS-CoV-2 Society spore surgical the disease tissues uncontrolled [DOI] 10.1111/myc.13335 PMC 바로가기 [Article Type] Article
Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, IndiaExpedited Published on 2021-09-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] Admission Amphotericin conducted coronavirus coronavirus disease COVID-19 COVID-19 pandemic diabetes Diabetes Mellitus Epidemiology evaluate fungi glucocorticoid hospitalized COVID-19 patients Hypoxemia increased mortality increases in India intensive care isavuconazole Mucormycosis multicenter outcome patients Posaconazole Prevalence respiratory infections Retrospective study SARS SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 study period survival Treatment uncontrolled underlying disease viruses zoonoses [DOI] 10.3201/eid2709.210934 PMC 바로가기 [Article Type] Expedited
The effect of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea and uncontrolled hypertension – Study design and challenges during the COVID-19 pandemicRandomized Controlled Trial Published on 2021-08-232022-10-04 Journal: Clinics [Category] SARS, 임상, [키워드] Analysis antihypertensive medication blood pressure brachial calculated co-morbidities co-primary endpoint COVID-19 pandemic CPAP defined Effect evaluate evaluated Final hypertension include kidney male medication multicenter nasal obstructive sleep apnea occur organ damage OSA outcome pandemic parameter Patient Placebo positive airway pressure post-hoc prevented Randomized controlled trial Sample size secondary Study design Treatment Trial uncontrolled uncontrolled hypertension unique [DOI] 10.6061/clinics/2021/e2926 PMC 바로가기 [Article Type] Randomized Controlled Trial
Natural products provide a new perspective for anti-complement treatment of severe COVID-19: a reviewReview Published on 2021-07-282022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] accounted Activation alleviate Anti-complement therapy Chinese chronic inflammation Coagulopathy complement Complement inhibitor contribute COVID-19 Critically ill Critically ill patient Cytokine storm drug resistance Efficacy Efficiency etiological hotspot immune response intravascular coagulation Mortality multiple organ failure natural natural products New organ dysfunction Perspective progressive respiratory failure reduction Regulation severity of COVID-19 Side effect supplementary material Symptom therapy Toxicity Treatment uncontrolled upstream with COVID-19 [DOI] 10.1186/s13020-021-00478-3 PMC 바로가기 [Article Type] Review
Targeting TLR4 Signaling to Blunt Viral-Mediated Acute Lung Injury둔기 바이러스 매개 급성 폐 손상에 대한 TLR4 신호 표적화Review Published on 2021-07-022022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome addition ALI antiviral agent Antiviral agents antiviral treatments approach ARDS caused circulating Consequences Critical cytokine Cytokine storm DAMPs danger-associated molecular pattern death effective Efficacy HMGB1 Hospitalization Infection Inflammatory response Influenza influenza infection influenza infections initiated innate immune response Interaction lead lethal infection life life threatening Local Lung injury PAMPs Pandemics pathogen pathogen-associated molecular pattern pathogen-associated molecular patterns Pathogens Pattern recognition pattern recognition receptor Pattern recognition receptors predicted PRRs respiratory respiratory distress Respiratory distress syndrome respiratory viral infections SARS-CoV-2 pandemic Signaling strain Symptom syndrome targeting TLR4 Treatment triggered uncontrolled Vaccine Viral viral infection viral infections Viral resistance virus viruses while [DOI] 10.3389/fimmu.2021.705080 PMC 바로가기 [Article Type] Review
Updates on clinical trials evaluating the regenerative potential of allogenic mesenchymal stem cells in COVID-19Review Article Published on 2021-06-302022-10-04 Journal: NPJ Regenerative Medicine [Category] 임상, 치료제, [키워드] acute respiratory distress acute respiratory syndrome Adaptive immune response alleviate ARDS caused clinical clinical study clinical trial clinics coronavirus coronavirus disease COVID-19 COVID-19 patient cytokine production Cytokine storm death decrease develop effective Efficacy enrolled evaluate fraction hypoxia immunomodulatory IMPROVE infected patient Inflammatory cytokine lack majority Mesenchymal stem cells Mild-to-moderate mortality rate MSC MSCs multiple organ failure outcome pandemic Patient patients performed placebo-controlled reduce regenerative potential Safe SARS-CoV-2 severe COVID-19 patients severe COVID-19 symptoms severe symptoms Standard of care statistically stem cell Support survival Symptoms syndrome therapeutic therapeutic potential Treatment uncontrolled viral infection [DOI] 10.1038/s41536-021-00147-x PMC 바로가기 [Article Type] Review Article
Effects of Social Distancing During the COVID-19 Pandemic on Anxiety and Eating Behavior—A Longitudinal StudyPsychology Published on 2021-06-012022-10-31 Journal: Frontiers in Psychology [Category] COVID-19, [키워드] Affect age Anxiety average cognitive conducted confinement Contact COVID-19 COVID-19 pandemic Data collection dietary behavior eating Effect emotional Evolution fatty groups Human Human evolution individuals investigation longitudinal measure mental health New coronavirus pandemic Participants Population positive Premenstrual raising recommendation reduce Regulation responsible SARS-CoV-2 Screening significantly significantly lower social distancing social isolation survival sweet Symptom Symptoms Transmission uncontrolled women [DOI] 10.3389/fpsyg.2021.645754 PMC 바로가기 [Article Type] Psychology