Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults조직 특이성 인식 TWAS(TSA-TWAS) 프레임워크는 HIV 양성 성인의 대사, 면역 및 바이러스 특성과의 새로운 연관성을 식별합니다.Research Article Published on 2021-04-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect affected AIDS Analysis applied association associations assumption Bilirubin bioinformatics CETP cholesterol cholesteryl ester clinical complex contribute current dataset enzyme eQTLs error rate evaluate experimental design expressed expression expression quantitative trait loci False positive Gene Expression Genes greater group High-density lipoprotein High-density lipoprotein cholesterol highlighting identify Laboratory loci mechanisms methodology multiple tissues novel association plasma pleiotropic gene power previous study promote Protein provide Quantitative regulated Regulatory replicated Research robust specificity statistical tissue tissues total bilirubin total bilirubin levels traits transcriptional transcriptionally transcriptome-wide transfer Triglyceride type I type I error UGT1A1 uridine uridine diphosphate variety Viral Viral load [DOI] 10.1371/journal.pgen.1009464 PMC 바로가기 [Article Type] Research Article
COMPARE Analysis, a Bioinformatic Approach to Accelerate Drug Repurposing against Covid-19 and Other Emerging EpidemicsResearch article Published on 2021-03-012022-10-05 Journal: SLAS discovery : advancing life sciences R & D [Category] SARS, 신약개발, 치료제, [키워드] Algorithm Analysis Anti-SARS-CoV-2 Activity Antibiotics Antiviral antiviral activity approach Bioinformatic bioinformatics cancer cell lines COMPARE analysis Compound COVID-19 described Dexamethasone drug Drug discovery Drug repurposing drugs growth Hydroxychloroquine in silico In silico methods include inhibitory methotrexate National Cancer Institute nicotinamide nucleosides Other Outbreaks pharmacological profile Repository repurposing resource Ritonavir SARS-CoV-2 structures tested uridine viral epidemics vitamin A vitamins were used [DOI] 10.1177/2472555220975672 [Article Type] Research article
A Negative Feedback Model to Explain Regulation of SARS-CoV-2 Replication and TranscriptionGenetics Published on 2021-02-262022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] acute respiratory syndrome caused cleavage site cleaving comprehensive analysis Control coronavirus Coronavirus disease 2019 CoV CoV replication COVID-19 CoVs derivatives drug explain expression level feedback Gene Expression genome sequence genomic RNA hosts influence knowledge mechanism Model molecular basis motif negative Nsp15 persistence proportion Protein regulate regulated Regulation regulation model Replication Result RNA SARS-CoV-2 sgRNA sgRNAs subgenomic RNA Transcription transcription regulatory sequence TRS TRSs turn uridine [DOI] 10.3389/fgene.2021.641445 PMC 바로가기 [Article Type] Genetics
Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2Tipiracil은 우리딘 부위에 결합하여 SARS-CoV-2의 Nsp15 엔도리보뉴클레아제 NendoU를 억제합니다.Article Published on 2021-02-092022-09-10 Journal: Communications Biology [Category] MERS, 치료제, [키워드] active site addition approved assays bind binding pocket binding site biochemical C-terminal catalytic catalytic domain cleave Colorectal cancer complex conserved Coronaviruses crystal structure crystal structures Crystallography drugs endoribonuclease EndoU enzyme Evidence FDA inhibit innate immune response Interaction Interference ions knowledge manganese mechanism mechanisms Molecular biology Nsp15 nucleotide nucleotides recognize responsible RNAs SARS-CoV-2 SARS-CoV-2 Nsp15 sequence specificity structural biology Structure therapeutic intervention tipiracil transition Treatment uracil uridine [DOI] 10.1038/s42003-021-01735-9 PMC 바로가기 [Article Type] Article
Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamicsArticle Published on 2021-01-272022-10-04 Journal: Nature Communications [Category] 변종, [키워드] Analysis biochemical Biochemistry catalytic cleavage conformational conserved coronavirus Coronaviruses Critical cryo-EM cryo-EM structure Cryoelectron microscopy crystal structure dataset Defense determine enzyme evade experiments facilitate Host mass spectrometry mechanism molecular Molecular dynamics simulation phosphate phosphodiester bond recognize regulate residue RNA RNA decay SARS-CoV-2 shown specificity structural framework Structure the SARS-CoV-2 uridine viral infection Viral RNA [DOI] 10.1038/s41467-020-20608-z PMC 바로가기 [Article Type] Article