viral adaptation

[키워드] accumulated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Affect antigenic evolution approach approved assumption available dose available doses build building can be used Characteristics clinical evaluation Combination condition consequence continuous spectrum coronavirus country COVID-19 infection COVID-19 infections Critical decrease dependent on determine disease severity distribution dose dosing regimen effective vaccine effort elicited epidemiological equity Evolution example first dose highlight immune Immune escape immune response immune responses Immunity immunized Impact imperative improves in some increase increase in individual individual immunity individuals Infection infections International Intervention long term medium middle mitigate mutations natural immunity Numerous outcome outcomes pandemic parameters phylodynamic population immunity Primary infection problems proportion public policies question rationale receiving reduce reduced replicate respiratory resulting robustness Safe SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 viral Science second dose secondary infections serological data severe acute respiratory syndrome Coronavirus short term single dose single vaccine Spread strength Stress subsequent susceptibility susceptible switching the timing the vaccine trajectory vaccinal vaccination vaccination rate vaccination rates Vaccine vaccine dose Vaccines variants Variation variations Viral viral adaptation viral antigenic evolution Viral load viral loads virus
[DOI] 10.1126/science.abg8663 PMC 바로가기 [Article Type] Research Article