Newly Emerged Antiviral Strategies for SARS-CoV-2: From Deciphering Viral Protein Structural Function to the Development of Vaccines, Antibodies, and Small MoleculesSARS-CoV-2에 대한 새로 등장한 항바이러스 전략: 바이러스 단백질 구조 기능 해독에서 백신, 항체 및 소분자 개발까지Review Published on 2022-05-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody antibody cocktail antibody treatment Antiviral caused chemical compounds clustered regularly interspaced short palindromic repeats compounds contribute coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 infection CRISPR development disease pathogenesis DNA dual exploration focus function functional Health Health crisis host cells inactive Infection inhibitors life cycle molecule monoclonal antibodies monoclonal antibody mRNA nonstructural proteins palindromic repeat Particles peptide-based Protein protein-based vaccine Protein-based vaccines Proteins provide research findings respiratory RNA vaccines SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 genome severe acute respiratory syndrome Coronavirus single-stranded Strategy structural proteins structure-function systematic review target targeted therapy targets the SARS-CoV-2 genome therapeutic option Therapeutic strategies therapy Treatment Vaccine Vaccine development Vaccines Viral viral life cycle Viral protein Viral proteins viral replication virus [DOI] 10.3390/ijms23116083 PMC 바로가기 [Article Type] Review
Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor팔미토일에탄올아미드(PEA)는 S 단백질 및 ACE-2 수용체와 상호작용하여 SARS-CoV-2 진입을 억제합니다Article Published on 2022-05-172022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE-2 activate activated adjuvant therapy Antiviral antiviral agent antiviral drug antiviral drugs antiviral potency binding bioactive lipids cascade cause cellular clinical test Clinical tests clinical trial connection Coronaviruses counteract Course COVID-19 COVID-19 pandemic Degradation derangement Disruption drop droplets energy entry receptor event Evidence fatty Fatty acid generate glycoprotein Glycoproteins highlight Huh-7 cells humans in viral Infection Inflammation inflammatory stimuli lack life cycle Lipid lipid droplets lipid metabolism lipids mechanism of action mechanisms membrane metabolism nutraceutical palmitoylethanolamide Pathways PEA Prevent protective effect Protective effects recent replicate Replication Research RNA virus S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein second significantly Spike protein the SARS-CoV-2 therapy Toxicity transcription factor Treatment Usage viral infection viral life cycle virus viruses VSV [DOI] 10.3390/v14051080 PMC 바로가기 [Article Type] Article
The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies숙주와 SARS-CoV-2의 전투: 선천 면역과 바이러스 회피 전략Review Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] activated Antiviral antiviral gene antiviral genes antiviral targets caused confirmed cases COVID-19 death Defense evade highlight Host host response immune immune evasion immune surveillance Immunity Inflammation Innate innate immune innate immune response innate immune system Innate immunity interferon interferons Invasion knowledge life cycle mechanism pathogen Pattern recognition pattern recognition receptor Pattern recognition receptors PRRs recognizing Replication restrict resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Signaling signaling cascade signaling transduction. Surveillance transduction type I type I and III interferons viral life cycle viral spread [DOI] 10.1016/j.ymthe.2022.02.014 PMC 바로가기 [Article Type] Review
Human phospho-signaling networks of SARS-CoV-2 infection are rewired by population genetic variantsSARS-CoV-2 감염의 인간 phospho-signaling 네트워크는 인구 유전 변이에 의해 재배선됩니다Article Published on 2022-05-012022-09-11 Journal: Molecular Systems Biology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] alterations Amino acid amino acid substitution amino acid substitutions Analysis ARFGEF2 association Comorbidities contributing to COVID-19 COVID-19 pathology disrupt Evolution Factor Genetic genetic factors Genetic variant Genetic variation Glucose highlight homeostasis Hospitalization Host host defenses host responses Human human genetic variation identify immune responses in viral induce Infection innate immune responses Inter-individual variation interferon interferon response involved kinase leads life cycle MAPK Missense modulated motif motifs nucleotide pathology Pathways phosphorylation site phosphorylation sites protein-protein interaction RNA splicing SARS-CoV-2 SARS-COV-2 infection sequence Sequence motifs severe COVID-19 Signaling signaling pathway signaling pathways Single nucleotide variant SNV SNVs STARD13 TANK TBC1D4 TBK1 translational TRIM28 Viral viral life cycle Viral proteins with COVID-19 [DOI] 10.15252/msb.202110823 PMC 바로가기 [Article Type] Article
Synthesis of Dihydrobenzofuro[3,2-b]chromenes as Potential 3CLpro Inhibitors of SARS-CoV-2: A Molecular Docking and Molecular Dynamics StudySARS-CoV-2의 잠재적인 3CLpro 억제제로서의 디하이드로벤조푸로[3,2-b]크로멘 합성: 분자 도킹 및 분자 역학 연구Article Published on 2022-04-202022-09-11 Journal: ChemMedChem [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro 3CLpro inhibitors acute respiratory syndrome acute respiratory syndrome coronavirus approach Bioactivity bioinformatics caused chymotrypsin Clustering analysis Compound Control coronavirus Coronavirus replication COVID-19 cysteine cysteine protease derivatives drug target Dynamics enzyme flavonoid flavonoids fused fused flavonoids Health in-silico Infection inhibitor inhibitor N3 inhibitors life cycle MERS-CoV methodology Middle East Middle East respiratory syndrome Coronavirus molecular molecular docking molecular dynamics Molecular dynamics simulation molecular interaction pandemic Potential Protein raised respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus synthesis therapeutic Toxicity unavailability viral life cycle [DOI] 10.1002/cmdc.202100782 PMC 바로가기 [Article Type] Article
Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory CompoundsSARS-CoV-2 3CLpro 억제제에 대한 진행 상황: SARS-CoV 3CLpro 펩티드 모방체 및 소분자 항염 화합물에서 영감Review Published on 2022-04-082022-09-11 Journal: Drug design, development and therapy [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] 3CLpro accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-inflammatory anti-inflammatory agents anti-inflammatory effect Anti-inflammatory effects Antiviral antiviral target caused Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Health inhibitor inhibitors inspiration life cycle pathophysiological peptidomimetics Progress protease protease inhibitors Protein proteinase SARS-CoV SARS-CoV-2 sequence homology Sequencing severe acute respiratory syndrome Coronavirus similarity small-molecule inhibitors. viral life cycle whole-genome sequencing [DOI] 10.2147/DDDT.S359009 PMC 바로가기 [Article Type] Review
SARS-CoV-2 M pro inhibitors: identification of anti-SARS-CoV-2 M pro compounds from FDA approved drugsArticle Published on 2022-04-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, [키워드] Analysis anti-SARS-CoV-2 binding affinity binding free energy caused complex Compound Coronavirus replication Correlation analysis COVID-19 COVID-19 pandemic cysteine protease database docking drug Drug discovery Drug repurposing end point enzyme FDA approved drug in vitro in vivo Interaction Ligand M pro molecular molecular docking Molecular dynamics simulation Molecular simulation N3 inhibitor outbreak public health R428 raised recent SARS-CoV-2 screened stability Structure-based virtual screening Teniposide viral life cycle Virtual screening VS-5584 [DOI] 10.1080/07391102.2020.1842807 PMC 바로가기 [Article Type] Article
Inhibition of the main protease of SARS-CoV-2 (Mpro) by repurposing/designing drug-like substances and utilizing nature’s toolbox of bioactive compoundsReview article Published on 2022-03-142022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 신약개발, [키워드] approved drug assays binding affinity candidate clinical trials Compound compounds consequence coronavirus Coronaviruses drug effective Enzyme inhibition Extracts in silico in vitro in vivo Infection inhibiting inhibition inhibitor inhibitors inhibitory involved main protease MPro mutations natural compounds Outbreaks pandemic protease protease active site Repurposed drugs Research respiratory SARS-CoV-2 shown vaccination viral life cycle viral replication virus [DOI] 10.1016/j.csbj.2022.03.009 [Article Type] Review article
Non-covalent SARS-CoV-2 M pro inhibitors developed from in silico screen hitsArticle Published on 2022-02-152022-10-04 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome analogues binding chemotype clinically Compound coronavirus culture cells denatured described effort evaluated examined FIVE group identify in silico in vitro inhibit inhibited inhibitor inhibitors M pro performed protease Protease activity Replication SARS-CoV-2 SARS-CoV-2 infections Screening selected Small molecules suppressed temperature the SARS-CoV-2 virus these compound tissue treat viral life cycle was determined X-ray crystallography [DOI] 10.1038/s41598-022-06306-4 PMC 바로가기 [Article Type] Article
Reconstruction of the unbinding pathways of noncovalent SARS-CoV and SARS-CoV-2 3CLpro inhibitors using unbiased molecular dynamics simulations비공유 SARS-COV 및 SARS-COV-2 3CLPRO 억제제의 비 결합 경로의 재구성 편향되지 않은 분자 역학 시뮬레이션Research Article Published on 2022-02-092022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 신약개발, 치료제, [키워드] 3CLpro accelerate addition binding binding pocket component COVID-19 pandemic drug drug design FDA approval help In silico method inhibit inhibitor Interaction Laboratory life cycle molecular molecular dynamics Molecular dynamics simulation molecular target pathway PDB Perspective protease protein-ligand interaction reconstruction Region Research residue residues SARS-CoV SARS-CoV-2 selected significantly these viruses Viral viral life cycle viruses water water molecule water molecules weakened [DOI] 10.1371/journal.pone.0263251 PMC 바로가기 [Article Type] Research Article