virions – Page 2 – Communicable Diseases Research

Published on 2022-05-032022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 진단, 치료기술,

[키워드] 19 outcome 2 RNAemia 2 viremia acute respiratory syndrome acute respiratory syndrome coronavirus Admission Antibody titers bloodstream Care clinical clinical outcomes Cohort coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 COVID-19 patient COVID-19 severity cross-sectional discharge disease severity electron tomography hazard ratio Health Organization Hospitalized Host immune response host immune responses ICU ICU Patients immune responses immunostaining indicate Inflammatory biomarker Inpatients Level Mortality Neutralizing antibody titer neutralizing antibody titers non-ICU outcome outcomes Outpatient outpatients Patient pellet plasma plasma sample plasma samples quantified reflect respiratory SARS-CoV-2 SARS. severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly significantly higher Viral Viral RNA Viremia virion virions virus particle virus particles Visualization vRNA WHO World Health Organization
[DOI] 10.1093/cid/ciab686 PMC 바로가기 [Article Type] Observational Study

Elucidating Design Principles for Engineering Cell-Derived Vesicles to Inhibit SARS-CoV-2 Infection

SARS-CoV-2 감염을 억제하기 위해 세포 유래 소포를 엔지니어링하기 위한 설계 원리 설명

Article

Published on 2022-05-012022-09-11
Journal: Small (Weinheim an der Bergstrasse, Germany)
[Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus addition administration antiviral efficacy binding affinities clinic coronavirus decoy decoys develop drug resistance Engineering evade Extracellular Extracellular vesicles feature foundation Health inhibit inhibitor inhibitors knowledge mAb mAbs monoclonal antibody nanovesicles. neutralization overcome Particle pathogen Pathogens principle provide Quantitative Recombinant protein repeated respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virions sera several variant several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sustained Therapeutics therapy Toxicity Vesicle vesicles Viral viral infections virions
[DOI] 10.1002/smll.202200125 PMC 바로가기 [Article Type] Article

SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13

기도 세포의 SARS-CoV-2 감염은 IL-13에 의해 영향을 받는 두 가지 확산 메커니즘인 강력한 바이러스 및 세포 방출을 유발합니다

Article

Published on 2022-04-192022-09-11
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected airway airways Allergic asthma analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral Asthma asthmatic cause caused Cell Cell culture cell cultures cell tropism cells ciliated cell ciliated cells coronavirus COVID-19 COVID-19 severity down-regulated gene down-regulated genes electron microscopy enzyme epithelial epithelial cells examined expression gene expression analyses Gene Expression Omnibus Genes glycoprotein HAE high risk host–virus interaction human airway human airway epithelial human airway epithelial cells IL-13 IL-13 cytokine immunohistochemistry In situ hybridization infected cells Infection infection. interferon interleukin interleukin-13 Intracellular involved keratan sulfate Lung disease mechanism Messenger RNA Microscopy MUC5AC mucin Mucus number of infected primary human airway reduced removal Replication RNA RNA-sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shedding shielding significantly Spread sulfate susceptibility Transmission Transport TRAP treated up-regulated viral egress viral entry Viral load Viral reservoir viral spread viral titers virions viruses were infected
[DOI] 10.1073/pnas.2119680119 PMC 바로가기 [Article Type] Article

In Vitro SARS-CoV-2 Infection of Microvascular Endothelial Cells: Effect on Pro-Inflammatory Cytokine and Chemokine Release

미세혈관 내피 세포의 시험관 내 SARS-CoV-2 감염: 염증성 사이토카인 및 케모카인 방출에 대한 영향

Article

Published on 2022-04-062022-09-11
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), SARS, 치료기술,

[키워드] ACE2 receptor Activation Analysis chemokine contribute coronavirus disease Coronavirus disease 2019 cytokine release Cytokines cytoplasm days post-infection dysfunction Effect electron ELISA endothelial Endothelial cell evaluated expressed expression Human Human Microvascular Endothelial Cells (HMEC-1) IFN-α IL-6 IL-6 level IL-6 levels IL-8 in vitro Inflammatory mediators inflammatory mediators. mRNA mRNA expression pandemic pro-inflammatory cytokine pro-inflammatory cytokines pro-inflammatory mediators Release RT-PCR SARS-CoV-2 SARS-COV-2 infection significantly higher significantly lower supernatant supernatants susceptible TEM These data thrombotic Thrombotic events tissue Tissue Factor TNF-α transmission electron microscopy uninfected viral amplification Viral load virion virions western blot Western blot analysis
[DOI] 10.3390/ijms23074063 PMC 바로가기 [Article Type] Article

Targeting SARS-CoV-2 nucleocapsid oligomerization: Insights from molecular docking and molecular dynamics simulations

SARS-CoV-2 뉴클레오캡시드 올리고머화 표적화: 분자 도킹 및 분자 역학 시뮬레이션의 통찰력

Article

Published on 2022-04-012022-09-11
Journal: Journal of biomolecular structure & dynamics
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법,

[키워드] Analysis anti-N drugs antiviral drug antiviral drugs binding binding affinity C-terminal C-terminal domain caused complex complexes Compound computational approach COVID-19 CTD distribution drug drugs effective examined filament FIVE followed by free energy free energy landscape highest binding affinity hydrogen Hydrogen bond increase indicated infect inhibitor insight MD simulation molecular molecular docking molecular dynamics Molecular dynamics simulation N protein nucleocapsid nucleocapsid. oligomerization outbreak packaged parameter PCA PDB population distribution potential mechanism potential mechanisms Protein Rapamycin Replication RMSD RMSF Sapanisertib SARS-CoV-2 nucleocapsid SARS-CoV-2 virus self-assembly Silmitasertib stability targeting the SARS-CoV-2 virus Transcription Viral protein Viral RNA virions
[DOI] 10.1080/07391102.2020.1839563 PMC 바로가기 [Article Type] Article

Basic virology of SARS-CoV 2

SARS-CoV 2의 기본 바이러스학

Review

Published on 2022-04-012022-09-11
Journal: Indian journal of medical microbiology
[Category] Coronavirus, COVID19(2023년), SARS, 치료법,

[키워드] 229E acute respiratory disease acute respiratory syndrome acute respiratory syndrome coronavirus basic bats bind cats Cell cell surface cellular membrane Characteristics clinical manifestation coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID 19 COVID-19 disease envelope Exocytosis followed by fusion Genome genomic genomic RNA global public health helical symmetry HKU1 host cell host cell cytosol hosts human coronaviruses humans Immunological response Infection mammalian membrane MERS MERS-CoV Mild NL63 nucleocapsid OC43 pandemic Pathogenesis pathogenic pathogenic coronavirus positive Protein receptor Receptor binding released RNA genome RNA synthesis S protein SARS CoV SARS CoV-2 SARS-CoV 2 SARS-CoV-2 Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spread structural proteins the S protein translation transported Vesicle vesicles viral genome viral genomic RNA viral replication virion virions Virology Virology. virus
[DOI] 10.1016/j.ijmmb.2022.02.005 PMC 바로가기 [Article Type] Review