A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Simulations Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Using a “systems therapeutic for physiological renormalization” approach to vaccine development. Covid-19 as an example백신 개발에 "생리학적 재정규화를 위한 시스템 치료" 접근 방식을 사용합니다. 코로나19를 예로 들어Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] 변종, [키워드] adaptive immune system approach current example induce infectious agent mimicry Mutation physiological Prevent Recombination replicate respiratory tract respiratory tracts sera Spread the disease therapeutic Vaccine Vaccine development variant virions virulent [DOI] 10.1080/21645515.2022.2043105 PMC 바로가기 [Article Type] Article
Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cellsArticle Published on 2022-11-022022-11-15 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 진단, [키워드] Affect analyses autophagy Better boost cancer cell cancer cell lines Cell cell type ciliated conducted COVID-19 pathology COVID19 Critical eight endocytosed enterocytes experiment expressed Factor Genetic genetic screen Gut help Host host cell human cell human lung identify impair Infection Interaction lentiviruses loss-of-function lysosomal lysosomal membrane overexpression plac8 plasma Protein regulate respiratory tract SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 viruses secretory cell single-cell SPNS1 spns1. susceptible viral entry viral infection virions [DOI] 10.15252/embj.2022110727 PMC 바로가기
The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 VariantsArticle Published on 2022-10-122022-11-16 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome addition association carried Cell cleavage cleavage site cleaved coronavirus D614G D614G mutation Delta dependent on epistasis epistatic interaction evaluate expressing expression increasingly Mutation omicron pandemic pathogenic Potential Protein proteolytic proteolytic cleavage pseudovirions pseudovirus pseudoviruses remained resulting S1 subunit S1/S2 S1/S2 cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 variant Site spike spike mutation spikes Spread stabilizing effect successive wave Transmissibility variant variants variants of concern Viral particles viral spike viral variant virions wild-type Wuhan [DOI] 10.1128/jvi.01301-22 PMC 바로가기
Mechanisms of host type I interferon response modulation by the nucleocapsid proteins of alpha- and betacoronaviruses알파 및 베타 코로나바이러스의 뉴클레오캡시드 단백질에 의한 숙주 유형 I 인터페론 반응 조절 메커니즘Review Published on 2022-10-012022-09-11 Journal: Archives of Virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha animals Antiviral antiviral responses Betacoronavirus cause coronavirus Coronavirus infections COVID-19 pandemic Critical diarrhea epidemic diarrhea facilitate Fatality rate function genomic RNA Health Host Human humans initial innate immune response involved knowledge modulate modulation Neonatal nucleocapsid protein Nucleocapsid proteins PEDV Replication responses responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown Signaling type I interferon viral genomic RNA Viral RNA virions virus Virus-host interactions [DOI] 10.1007/s00705-022-05513-8 PMC 바로가기 [Article Type] Review
Single-particle detection of native SARS-CoV-2 virions by microfluidic resistive pulse sensingArticle Published on 2022-10-012022-11-15 Journal: Colloids and surfaces. B, Biointerfaces [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome coronavirus described determine distribution mean value particle size distribution pulse reported Resistive pulse sensing SARS-CoV-2 SARS-CoV-2 virion size distribution spike Spike protein ultrastructure viral envelope virions was used [DOI] 10.1016/j.colsurfb.2022.112716 PMC 바로가기
A counterintuitive antibody cocktail disrupts coxsackievirusArticle Published on 2022-09-142022-11-15 Journal: Cell Host & Microbe [Category] Fulltext, MERS, 진단, [키워드] accelerated antibody cocktail COVID-19 pandemic coxsackievirus disrupt function Infectious disease monoclonal antibody Prevent therapeutic treat virions [DOI] 10.1016/j.chom.2022.08.010 PMC 바로가기
Immunomolecular assay based on selective virion capture by spike antibody and viral nucleic acid amplification for detecting intact SARS-CoV-2 particlesArticle Published on 2022-09-052022-11-15 Journal: Journal of Nanobiotechnology [Category] SARS, 치료기술, [키워드] Accuracy acute respiratory syndrome aluminum amplification analyses antibody applied Characteristics clinical sample coefficient Complete Complete virions conditions convalescent coronavirus coronavirus disease COVID-19 Critical detect diagnose facilitate Factor glycoprotein Human immunodeficiency virus human serum Immune escape Immunomolecular detection IMPROVE infection risk Influenza isolation rooms limit of detection molecular monoclonal antibody Mutation nucleic acid amplification Outbreaks parameters Patient pseudovirus quantified Quantitative reduced reverse transcription PCR reverse transcription-PCR SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 pseudovirus selective specific antibodies spike stability Vaccine Variation Viral load viral nucleic acid viral spike viral titer virion virions virus virus detection virus isolation viruses [DOI] 10.1186/s12951-022-01558-8 PMC 바로가기
Contributions of the N-terminal intrinsically disordered region of the severe acute respiratory syndrome coronavirus 2 nucleocapsid protein to RNA-induced phase separationArticle Published on 2022-09-012022-11-16 Journal: Protein Science : A Publication of the Protein Soc [Category] SARS, 변종, [키워드] activity acute respiratory syndrome addition affected change coronavirus COVID-19 infections decrease droplet engage Genome genomic RNA host infection induce intrinsically liquid-liquid phase separation modulating molecular Mutation N-terminal N-terminus NMR nucleocapsid protein omicron phosphorylated post-translational modification Protein Replication RNA RNA concentration SARS-CoV-2 Structural properties the SARS-CoV-2 Transcription undergo variant viral replication virions [DOI] 10.1002/pro.4409 PMC 바로가기
Raman Fingerprints of the SARS-CoV-2 Delta Variant and Mechanisms of Its Instantaneous Inactivation by Silicon Nitride BioceramicsSARS-CoV-2 Delta 변이체의 라만 지문과 질화규소 바이오세라믹에 의한 즉각적인 비활성화 메커니즘Article Published on 2022-08-122022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Amino acid arginine B.1.617.2 collected Delta delta variant effective environmental sanitation fingerprint fraction hydrophobic hydrophobic interaction hydrophobic interactions inactivation Inorganic compound instantaneous instantaneous virus inactivation Japanese Lineage marker mechanism methionine molecular Mutation mutations Nitride Occurrence Oxidation Particle Protein purine purines pyrimidines Raman spectroscopy reaction receptor recorded referred to residue residues RNA Safe SARS-CoV-2 secondary structure silicon silicon nitride. sulfur the SARS-CoV-2 tyrosine variant viral inactivation virion virions virus [DOI] 10.1021/acsinfecdis.2c00200 PMC 바로가기 [Article Type] Article