virus clearance – Page 2 – Communicable Diseases Research

Can’t smell the virus: SARS-CoV-2, chromatin organization, and anosmia

바이러스 냄새를 맡을 수 없음: SARS-CoV-2, 염색질 조직 및 후각 상실

Comment

Published on 2022-05-092022-09-11
Journal: Developmental cell [Category] COVID19(2023년), SARS, 유전자 메커니즘,

JAK inhibitors and COVID-19

JAK 억제제 및 COVID-19

Review

Published on 2022-04-012022-09-11
Journal: Journal for immunotherapy of cancer [Category] COVID19(2023년), SARS, 진단, 치료제,

[키워드] activated added Antiviral antiviral molecules Autoimmunity Baricitinib benefit clinical experience clinical trials coded concerning contributing to COVID-19 COVID-19 treatment cut-off cytokine Cytokine storm Cytokines differentiation Effect Effects Evolution family Graft hematologic hematologic neoplasms Human genome immune regulation immune response Immunosuppression immunosuppressive effect immunosuppressive effects indicated induce inhibited innate immune response interferons involved issue Jak JAK inhibitor jak inhibitors JAK1 JAK2 JAK3 JAKi janus Janus kinase kinases Meta-analysis moment Neoplasms nezulcitinib outcome pathogenic pathway Pathways patients treated patients with COVID-19 Phase 3 trials proliferation randomized clinical trial RCT reaction receptor reduce mortality rheumatic disease Rheumatic diseases risk reduction ruxolitinib SARS-COV-2 infection severe COVID-19 Side effect Signaling Significant Standard of care subsequent suggested survival the SARS-CoV-2 the WHO Therapies therapies, investigational. Tofacitinib transmembrane Treatment trials TYK2 Type I IFN type I interferons Viral viral replication virus clearance
[DOI] 10.1136/jitc-2021-002838 PMC 바로가기 [Article Type] Review

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans

SARS-CoV-2 단일클론항체 조합인 AZD7442는 인간이 아닌 영장류를 보호하고 인간에서 반감기가 연장됩니다.

Article

Published on 2022-03-092022-09-11
Journal: Science Translational Medicine [Category] MERS, SARS, 변종, 비임상, 진단, 치료기술,

[키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration angiotensin angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor antibody benefit binding cell entry cilgavimab Combination Concentration convalescent serum coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 death Epitopes extrapolation fold functions geometric geometric mean greater half-live healthy Human individual Infection Initially Intramuscular injection lung mAb mAbs monoclonal antibodies monoclonal antibody combination nasal mucosa neutralize Neutralizing titer nonoverlapping epitope nonoverlapping epitopes participant Phase 1 phase 1 study Prevent prevented Prophylactic Protective provided receptor Receptor binding domain reduce remained respiratory risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant serum severe acute respiratory syndrome Coronavirus severe disease Spike protein Spike protein receptor binding domain tested the spike protein therapeutic Tixagevimab treat Treatment Vaccines Viral viral spike protein virus virus clearance
[DOI] 10.1126/scitranslmed.abl8124 PMC 바로가기 [Article Type] Article

Inactivated Rabies Virus Vectored MERS-Coronavirus Vaccine Induces Protective Immunity in Mice, Camels, and Alpacas

Immunology

Published on 2022-01-312022-11-01
Journal: Frontiers in Immunology [Category] COVID-19,

Cytotoxic T-Cell-Based Vaccine against SARS-CoV-2: A Hybrid Immunoinformatic Approach

Article

Published on 2022-01-302022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] 3D structure acquired immunity administration Antigen Antigen presentation binding Cancer immunotherapy canonical cellular cellular immunity characterized Coverage COVID-19 convalescent patient cytotoxic cytotoxic T lymphocytes dendritic cells epithelia epitope Epitopes highest HLA HLA class I hybrid IEDB immune protection immune response immune stimulation immunization immunogenic immunoinformatics in silico In silico methods intranasal long term immunity molecular docking Molecular docking study NetMHCpan non-allergenic non-toxic parameter peptide platform Population positive Probability protein folding provide provided robust SARS-CoV-2 T-Cell vaccine screened stimulate Structure synthetic long peptide T-cells Toll-like receptor Toxicity vaccination VaxiJen 2.0 Viral mutations virus clearance
[DOI] 10.3390/vaccines10020218 PMC 바로가기 [Article Type] Article

Deciphering Respiratory-Virus-Associated Interferon Signaling in COPD Airway Epithelium

Review

Published on 2022-01-132022-10-30
Journal: Medicina [Category] COVID-19,

[키워드] accelerated activate Activation adaptive affecting airway epithelial cell airway epithelial cells airway epithelium Antiviral antiviral response antiviral therapy cascade characterized contribute COPD death Defense Deterioration disease severity effective Epidemic epithelium exhibit facilitate healthy Hospitalization Host IFN IFN signaling Immune homeostasis Immunity impairment increased risk Inflammatory mediators Inhaled Interaction interferon signaling Lower respiratory tract lung lung disorder Lung function mechanism mechanisms Mortality pathogen Patient patients pulmonary inflammation reduce Research respiratory respiratory virus response resulting secondary bacterial infection secreting severe disease Signaling subsequent susceptibility susceptible the interferon therapeutic intervention understanding viral infection virus virus clearance
[DOI] 10.3390/medicina58010121 PMC 바로가기 [Article Type] Review

SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy Impairment

Microbiology

Published on 2022-01-062022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] acute respiratory syndrome binding cause caused cells co-immunoprecipitation Coronavirus-2 Critical cross cyclosporin A Defense dsRNA early stage energy metabolism expression fluorescent homeostasis host cell increase in inhibited initiated innate immune response Interaction involved knockdown Microscopy Mitochondria mitochondrial mitochondrial accumulation mitochondrial dysfunction mitochondrial membrane mitophagy performed Proteins Quality control reactive oxygen specy recruitment reduced RNA ROS SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selective substrate Tom20 Viral load viral RNA localization virus clearance
[DOI] 10.3389/fmicb.2021.780768 PMC 바로가기 [Article Type] Microbiology

T cell phenotypes in COVID-19 – a living review

Short Communication

Published on 2021-12-292022-10-29
Journal: Oxford Open Immunology [Category] COVID-19,

Impairment of T cells’ antiviral and anti-inflammation immunities may be critical to death from COVID-19

Mathematics

Published on 2021-12-222022-10-28
Journal: Royal Society Open Science [Category] COVID-19,

Intrauterine Fetal Demise After Uncomplicated COVID-19: What Can We Learn from the Case?

복잡하지 않은 Covid-19 후 자궁 내 태아 사망 :이 사건에서 무엇을 배울 수 있습니까?

Case Reports

Published on 2021-12-192022-09-10
Journal: Viruses [Category] SARS, 치료기술, 치료법,

[키워드] abnormality ACE2 Autopsy B-lymphocytes Basigin Can case study CD147 changes in Clinical course clumping COVID-19 death demise deposition dominant dominant receptor Endothelial cell epithelial expression fetal fetal demise fetal movements fetus histology Immunity immunohistochemistry In situ hybridization indicate Infection infiltration interstitial Ischemia lead limit lung lung tissue maternal immunity Mild Morphological mother Neutrophils nucleocapsid over Patient persistence persistent infection Placenta placental placental tissue positive PCR test Pregnancy pregnant pregnant women prevalent Protein receptor reported RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid severity Spike protein syncytiotrophoblast T-lymphocyte the SARS-CoV-2 TMPRSS2 transfer transplacental infection transplacental transmission trophoblast villi Viral viral infection virus virus clearance
[DOI] 10.3390/v13122545 PMC 바로가기 [Article Type] Case Reports