Delayed SARS-COV-2 clearance in infected persons in GhanaOriginal Article Published on 2023-06-012024-09-05 Journal: Ghana Medical Journal [Category] update2024, [키워드] Isolation RT-PCR SARS-CoV-2 sputum virus clearance [DOI] 10.4314/gmj.v57i2.3 PMC 바로가기 [Article Type] Original Article
Characterization of oral bacterial and fungal microbiome in recovered COVID-19 patientsarticle Published on 2023-05-092024-09-05 Journal: BMC Microbiology [Category] update2024, [키워드] COVID-19 oral bacteria Oral fungi recovered patients virus clearance [DOI] 10.1186/s12866-023-02872-3 PMC 바로가기 [Article Type] article
Antibody response and intra-host viral evolution after plasma therapy in COVID-19 patients pre-exposed or not to B-cell-depleting agentsArticle Published on 2022-11-012022-11-15 Journal: British Journal of Haematology [Category] SARS, 진단, [키워드] anti-CD20 anti-CD20 therapy Anti-spike anti-Spike IgG antibody antibody kinetics B-cell clinical care clinical status clinical symptom Complete contribute convalescent convalescent plasma COVID-19 patient Decline donors eligible evaluated Follow-up hospitalized COVID-19 patients humoral Humoral immunity IgG Immune escape Immunocompromised Immunocompromised patients Immunoglobulin impair lymphopenia majority management mRNA-based vaccine mRNA-based vaccine plasma mutation rate Patient patients treated plasma receiving SARS-CoV-2 SARS-CoV-2 viral load SARS-CoV-2-specific antibodies severity spike mutations survival therapy titre viral control viral evolution virus clearance WHO whole-genome sequencing World Health Organization [DOI] 10.1111/bjh.18450 PMC 바로가기
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in miceArticle Published on 2022-09-282022-11-15 Journal: Science Translational Medicine [Category] SARS, 치료제, [키워드] acute respiratory distress acute respiratory syndrome alveolar Antiviral cells chronic disease chronic inflammation clinical recovery collagen composed coronavirus coronavirus disease COVID-19 develop disease severity dysfunction dysregulated EIDD-2801 epithelial fibroblasts fibrosis histologic finding humans identify Immune cell individual Intervention lack lesion longitudinal lung abnormality lymphoid mice mouse-adapted SARS-CoV-2 murine model Nintedanib PASC Pathogenesis pathway Population proliferative provide pulmonary disease reduced regions SARS-CoV-2 SARS-COV-2 infection structures subpleural subset syndrome tissue samples transcriptional virus clearance [DOI] 10.1126/scitranslmed.abo5070 PMC 바로가기
Interferon α-2b spray shortened viral shedding time of SARS-CoV-2 Omicron variant: An open prospective cohort study인터페론 α-2b 스프레이는 SARS-CoV-2 오미크론 변이체의 바이러스 배출 시간을 단축: 공개 전향 코호트 연구Article Published on 2022-08-052022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 치료제, [키워드] 95% CI administration adverse effect against SARS-CoV Analysis antiviral activity China Cohort cohort study control group COVID-19 Effect Effectiveness enrolled examined experimental group first positive IFN IFN α IFN α-2b spray interferon less omicron Omicron variant participant Patient prospective cohort study protective effect protective factor SARS-CoV-2 SARS-CoV-2 Omicron variant SARS-CoV-2 variant Shanghai shown significantly spray Spread subgroup analysis the median treatment effect treatment effects univariate Cox regression univariate Cox regression analysis Vaccine viral shedding viral shedding time virus clearance virus transmission [DOI] 10.3389/fimmu.2022.967716 PMC 바로가기 [Article Type] Article
SARS-CoV-2 accelerated clearance using a novel nitric oxide nasal spray (NONS) treatment: A randomized trialArticle Published on 2022-08-012022-10-06 Journal: Lancet Reg Health Southeast Asia [Category] 진단, [키워드] 1:1 95% CI accelerate accelerated age Anti-viral treatment assessment baseline clearance clinical trial Comorbidities comparable Concentration COVID-19 COVID-19 illness defined demonstrated double-blind Endpoint evaluated funding greater greater transmissibility high risk individuals infected with SARS-CoV-2 Laboratory Limited median Mild multicentre mutate nasal Nasal spray nasal swab nitric oxide nostril parallel group Patient pharmaceutical Placebo placebo-controlled polymerase chain primary analysis population progression proportion provided Randomized randomized trial receiving reduce reverse transcription RT-PCR SARS-CoV-2 SARS-CoV-2 RNA secondary Seven study medication symptomatic the placebo group therapy Treatment treatment difference vaccination Viral load virus virus clearance virus RNA [DOI] 10.1016/j.lansea.2022.100036 PMC 바로가기 [Article Type] Article
Prevalence of COVID-19-associated symptoms during acute infection in relation to SARS-CoV-2-directed humoral and cellular immune responses in a mild-diseased convalescent cohort경증 회복기 코호트에서 SARS-CoV-2 유도 체액 및 세포 면역 반응과 관련하여 급성 감염 중 COVID-19 관련 증상의 유병률Article Published on 2022-07-012022-09-12 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute infection antibody antiviral immunity association Cellular immune response cellular immune responses Cohort convalescent convalescent individual correlation cough COVID-19 COVID-19 symptom COVID-19 symptoms disease severity effective eight evaluated humoral humoral immune response humoral immune responses IgG immune immune response intensities intensity Loss of Smell majority no difference polymerase chain positive Prevalence Prevent questionnaire recent reduced SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2-specific T cell Serum level severe symptom severity shown Symptom symptom severity Symptoms T cell response T cells virus clearance were assessed [DOI] 10.1016/j.ijid.2022.04.019 PMC 바로가기 [Article Type] Article
Antibodies from convalescent plasma promote SARS-CoV-2 clearance in individuals with and without endogenous antibody response회복기 혈장의 항체는 내인성 항체 반응이 있거나 없는 개인에서 SARS-CoV-2 제거를 촉진합니다Clinical Trial Published on 2022-06-152022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] 95% CI absence Adaptive immunity adjusted hazard ratio adverse events affected antibody Antibody Response clearance Clinical research Comorbidity Comprehensive conducted convalescent plasma Convalescent plasma therapy Corona COVID-19 Critical demonstrated disease status Efficacy evidenced faster hazard ratio hospitalized COVID-19 patient human infection human infections Immunotherapy individual Innovation Intervention IQR Kaplan-Meier analysis laboratory parameter median interval Mortality neutralization Neutralizing neutralizing antibody onset of symptom parameter Phase I plasma plasma therapy pool principle priority Program promote recipient recipients Red respond Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 clearance SARS-CoV-2 vaccines serological significantly survival therapeutic Therapeutics therapy transfusion-related adverse event transfusion-related adverse events Trial university University of Zurich Viral viral clearance Viral load Viremia Virological virus clearance [DOI] 10.1172/JCI158190 PMC 바로가기 [Article Type] Clinical Trial
Trajectory patterns of SARS-CoV-2 neutralising antibody response in convalescent COVID-19 patients Research Published on 2022-05-192022-10-05 Journal: Communications Medicine [Category] 치료기술, 치료법, [키워드] Adaptive immune response Analysis association blood sample Characteristics chronic illnesses Clinical data collected contribute convalescent COVID-19 patient convalescent patient COVID-19 patient diagnosis of SARS-CoV-2 Health heterogeneity Hong Kong Infection initial laboratory data latent class neutralising antibody occur Older Patient performed Prevent Re-infection Regression model Result risk SARS-CoV-2 SARS-COV-2 infection Seroconversion subject subsequent surveillance data sVNT symptomatic symptomatic patient Symptomatic patients tested the SARS-CoV-2 trajectory Vaccination strategy Variability virus clearance Virus neutralisation were measured [DOI] 10.1038/s43856-022-00119-2 [Article Type] Research
Combined kinetic analysis of SARS-CoV-2 RNAemia, N-antigenemia and virus-specific antibodies in critically ill adult COVID-19 patients중증 성인 COVID-19 환자의 SARS-CoV-2 RNA혈증, N-항원혈증 및 바이러스 특이 항체의 결합 운동 분석Article Published on 2022-05-182022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] adult COVID-19 patient analyses Analysis antibody Antibody detection antigenemia bloodstream CAST Cohort collected Combined component COVID-19 patient COVID-19 patients Critically ill decreasing detection rate dissemination examined Free help immunoassays immunochromatography inverse correlation kinetic analysis lateral flow median median age median time nucleocapsid onset of symptoms patients performed plasma RBD Receptor binding domain respiratory RNA RT-PCR assay SARS-CoV-2 SARS-CoV-2-RBD specific antibodies specimen symptoms onset upper respiratory tract Viral Viral load virus virus clearance virus-specific antibodies [DOI] 10.1038/s41598-022-12461-5 PMC 바로가기 [Article Type] Article