Prediction of the incubation period for COVID-19 and future virus disease outbreaksCOVID-19의 잠복기 및 향후 바이러스 질병 발생 예측Research Article Published on 2020-11-302022-09-10 Journal: BMC Biology [Category] Fulltext, SARS, 변종, [키워드] approach connection coronavirus COVID-19 COVID-19 pandemic described determine develop disease Disease progression disease severity epidemiological estimates expected facilitate Factor feature Features GC content help in viral Incubation period individuals machine learning optimization outbreak Outbreaks pandemic pathogenic pathogenic viruses positive correlation predicted prediction Predictive protein-coding gene protein-coding genes public health quarantine required respiratory Respiratory disease respiratory infections respiratory viral Result RNA virus SARS-CoV-2 Viral Viral diseases virus Virus Disease virus genome virus genomes virus pathogenesis viruses [DOI] 10.1186/s12915-020-00919-9 PMC 바로가기 [Article Type] Research Article
SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19SOCS, 내재 독성 인자 및 COVID-19의 치료Review Published on 2020-10-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome antagonist antiviral peptide block caused Cell coronavirus COVID-19 COVID-19 pandemic cytokine signaling death Defense effective embryonic Factor Factors herpes simplex herpes simplex virus Herpes Simplex Virus 1 Host HSV-1 IFN IFNγ induce infections inflammatory disease Influenza influenza A influenza A virus inhibit inhibitor inhibitors inhibitory inhibitory activity interferon interferon gamma intrinsic JAK2 kinase kinases KIR leads mechanism mice Neonatal neonatal death Other palmitate pathogenic pathogenic virus penetration peptide phosphorylated Prevent Prophylactic required respiratory SARS-CoV-2 SARS-CoV2 Severe acute respiratory syndrome shown SOCS1 SOCS3 Spike protein STAT STATs suppressor therapeutic transcription factor TYK2 type I tyrosine tyrosine kinase vaccinia virus Viral Viral virulence virulence virulence factors virus virus pathogenesis viruses [DOI] 10.3389/fimmu.2020.582102 PMC 바로가기 [Article Type] Review
Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19Review Article Published on 2020-10-192022-10-30 Journal: International Journal of Genomics [Category] COVID-19, [키워드] affecting Antiviral Asian Cell Clinical outcome Clinical practice COVID-19 criteria database disease severity English feature Genetic polymorphism genetics Host immune response humans implicated mechanism Medicine objective pathophysiological polymorphism populations response Result SARS-CoV SARS-CoV infection systematic review translational virus virus pathogenesis [DOI] 10.1155/2020/6901217 PMC 바로가기 [Article Type] Review Article
Application of System Biology to Explore the Association of Neprilysin, Angiotensin-Converting Enzyme 2 (ACE2), and Carbonic Anhydrase (CA) in Pathogenesis of SARS-CoV-2Research Published on 2020-06-192022-10-27 Journal: Biological Procedures Online [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome Affect affected angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) Anhydrase appear application approach association biochemical pathway Biology Blood blood circulation Carbonic anhydrases (CAs) caused cellular Chest complex Concentration coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient death deaths diarrhea disorder dry cough expected facilitated fatigue Fever fibrosis finding functions highest Infection Inflammation information key factor less loss of taste Lungs membrane metallo-endopeptidase MME neprilysin organ Pain pathogenesis of SARS-CoV-2 Pulmonary edema Quality of life RAS receptor reduction in renal Renin Angiotensin System (RAS) respiratory acidosis Result SARS-CoV-2 skin rashe Symptom System System biology the United State therapeutic strategy to define Treatment virus virus pathogenesis [DOI] 10.1186/s12575-020-00124-6 PMC 바로가기 [Article Type] Research
Genome-wide computational prediction of miRNAs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) revealed target genes involved in pulmonary vasculature and antiviral innate immunityOriginal Article Published on 2020-06-012022-10-30 Journal: Molecular Biology Research Communications [Category] COVID-19, [키워드] acute respiratory syndrome analysed Analysis Antiviral Apoptosis BMPR2 cellular components China Community Complete coronavirus COVID-19 EGF etiology Evidence FGF receptor function Gene ontology gene silencing Genome genome sequence help human gene Human genome Innate immunity involved mature miRNA microRNA miRNA outbreak p53 pathway Pathways pre-miRNA pre-miRNAs predict predicted receptor signaling Research retrieved RNA genome RNA viruses SARS-CoV-2 Signaling target target gene Target genes the disease vasculature VEGF signaling virus pathogenesis [DOI] 10.22099/mbrc.2020.36507.1487 PMC 바로가기 [Article Type] Original Article
Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin miceArticle Published on 2017-04-112023-06-14 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, [키워드] CD26 Emerging pathogen interferon Spike protein virus pathogenesis [DOI] 10.1073/pnas.1619109114 PMC 바로가기
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and PathogenesisResearch Article Published on 2014-05-012022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence accompanied Activation activity acute respiratory distress Affect airway Amino acid ARDS assays ATPase attenuate Cell channel compensatory mutation complexes Concentration correlated Critical cytokine cytosolic death Deletion demonstrated died disease Diseases displaying E gene E protein edema ENCODE envelope eventually death experiment fitness highly pathogenic IL-1β IL-6 in viral induce inducer Infection infections Inflammasome inflammasome activation Inflammatory cytokine Inflammatory response innate immune system Interaction involved Ion ion homeostasis less Level lost weight lung lung damage lung epithelia macromolecular maturation mechanism mice multifunctional protein mutant mutant viruses Mutation outcome Pathogenesis pathology produced progression promote Protein pulmonary damage reduced reducing required respiratory restored SARS-CoV SARS-CoV E SARS-CoV infection sequence severe hypoxemia significantly suppressed survived syndrome therapy this system TNF translated transmembrane protein Transport viral infection virulence virus virus growth virus pathogenesis virus production wild-type [DOI] 10.1371/journal.ppat.1004077 PMC 바로가기 [Article Type] Research Article
SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent MechanismResearch Article Published on 2010-04-082022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] acute lung injury acute respiratory syndrome affecting alveolar inflammation ARDS Author BALB/c mice caused cell proliferation clinical disease coronavirus death demonstrated Dependent died Diffuse alveolar damage ENhance Epidemic evaluated highly pathogenic I, II independent Infected Infection innate immune innate immune response Innate immunity interferon interferon signaling knockout mice lack liver Lung disease Lung injury Lung pathology MA15 mechanism mice molecular mechanism Mortality Mouse models other tissue outcomes Pathogenesis Pathways Post-infection PROTECT Protein pulmonary fibrosis pulmonary lesion question receptor regulated respiratory respiratory virus SARS Coronavirus SARS pathogenesis SARS-CoV SARS-CoV infection severe severe disease Signaling spleen Stat1 the epidemic Type type I type III interferon viral pathogenesis virus virus pathogenesis virus titer Virus-host interaction viruses weight loss wildtype [DOI] 10.1371/journal.ppat.1000849 PMC 바로가기 [Article Type] Research Article