Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging VariantsArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] SARS, 변종, [키워드] acidic pH airway Airway organoids Cell cellular ciliary ciliary damage ciliated cell Culture Delta Efficiency generate higher infectivity Human imperative in vitro model Infection Infectivity Interaction maturation Model monolayer morphologically nasal nasal epithelial cell nasal epithelium nasal organoids nasopharyngeal omicron Organoid Primary infection protocol remained replicative fitness respiratory respiratory viruses robust SARS-CoV-2 tight junction tight junctions Transmissibility Transmission upper upper respiratory infection upper respiratory tract variant variants viral pathogenesis virus spread [DOI] 10.1128/mbio.01944-22 PMC 바로가기
SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patientsSARS-CoV-2는 시험관 내 및 COVID-19 환자에서 1차 인간 면역계 세포를 생산적으로 감염시킵니다Article Published on 2022-08-172022-09-11 Journal: Journal of Molecular Cell Biology [Category] SARS, 진단, 치료기술, 치료법, [키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Apoptosis appear B and T lymphocytes B cells B lymphocyte B lymphocytes CD4+ T lymphocyte Cell circulating leukocytes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytokine storm disease pathogenesis disease severity double-stranded RNA expressive flow cytometry hallmark Host Human immune system hyperinflammatory state Immune cell immune cells immune dysfunction immunofluorescence analysis implication in vitro indicated infect Infection inflammatory state leukocyte leukocytes lung tissue Lymphocytes lymphocytopenia monocyte Monocytes mononuclear cell mononuclear cells outcome patients PBMC Peripheral blood Peripheral blood mononuclear cell (PBMC) Peripheral blood mononuclear cells Prognosis progression Replication respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro severe acute respiratory syndrome Coronavirus susceptible sustained symptom onset T cell T lymphocytes Viral viral replication Viral RNA virus spread [DOI] 10.1093/jmcb/mjac021 PMC 바로가기 [Article Type] Article
Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다Article Published on 2022-08-102022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acquisition activate activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alphavirus appear cathepsin Cathepsins Cell Cell fusion change coronavirus COVID COVID-19 disease Cytokines Deletion determined by endosome Entry mechanism entry pathway Evolution experimental system expressing S protein expression FCS furin furin cleavage furin cleavage site hallmark human population immune in vitro induce infected with SARS-CoV-2 infecting Infection inhibitor inhibitors lack leads Lineage mAbs mechanism media mRNA vaccines Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody pro-inflammatory cytokines pro-inflammatory response pseudoinfectious viruses pseudovirus pseudoviruses receptor released respiratory S protein S1 secretion S1 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 S protein secrete sera severe acute respiratory syndrome Coronavirus shown Site Spike protein Spread spreading Syncytia syncytium syncytium formation the S protein the S1 subunit TLR4 TMPRSS2 TMPRSS2 expression variant Viral viral evolution virus virus entry virus spread [DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article
Nanoscale Technologies in the Fight against COVID-19: From Innovative Nanomaterials to Computer-Aided Discovery of Potential Antiviral Plant-Derived DrugsCOVID-19와의 싸움에서 나노스케일 기술: 혁신적인 나노물질에서 잠재적인 항바이러스 식물 유래 약물의 컴퓨터 지원 발견까지Review Published on 2022-07-302022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Antiviral antiviral activity computational approach develop drug drug delivery systems identify increasingly measure Measures molecular molecular docking nanodecoys Nanomaterial nanomaterials nanosystems Pandemics Pathways penetration Potential reducing SARS-CoV-2 SARS-CoV-2 cell technology terpenoids therapeutic agents virus spread virus spread control measures. [DOI] 10.3390/biom12081060 PMC 바로가기 [Article Type] Review
Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission Research Published on 2022-07-072022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] clinical testing Community Concentration Critical detect effort estimate Factor genomic genomic sequence High-resolution IMPROVE Infection instance less limit Lineage Prevalence protocol provide Public health interventions resources reveal SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant sequence Sequencing Spread Surveillance Transmission variant variants variants of concern virus virus spread virus strain wastewater [DOI] 10.1038/s41586-022-05049-6 [Article Type] Research
The 2022 outbreak and the pathobiology of the monkeypox virusArticle Published on 2022-07-012022-11-15 Journal: Journal of autoimmunity [Category] 진단, [키워드] addition African Antiviral antiviral therapies body fluids CDC center chills clade clades Congo basin Control disease effective Europe fatigue Fever headache Host hosts identity include individual Infection Infectious disease International lymph nodes mitigate Monkeypox Monkeypox outbreak 2022 muscle aches nasopharyngeal National Nigeria North America outbreak pandemic Pathogenesis Prevalence Prevent prevention raised replicate reported Respiratory droplets returned rodent shown specific treatment Spread Symptom The United States through contact Transmission transmitted Travel USA Vaccine viral pathogenesis virus virus infection virus spread Washington West while WHO World Health Organization [DOI] 10.1016/j.jaut.2022.102855 PMC 바로가기
SARS-CoV-2 Circulation during the First Year of the Pandemic: A Seroprevalence Study from January to December 2020 in Tuscany, Italy팬데믹 첫 해 동안의 SARS-CoV-2 순환: 이탈리아 투스카니에서 2020년 1월부터 12월까지의 혈청 유병률 연구Article Published on 2022-06-302022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] affected anti-receptor-binding domain antibody collected country COVID-19 cases diffusion ELISA epidemiological General population IgG IgM IgM and IgG in-house ELISA increase in Italy neutralizing antibody positive Prevalence RBD RBD IgG SARS-CoV-2 Seroprevalence serum sample Siena subsequent Surveillance tested the SARS-CoV-2 Tuscany virus spread Year [DOI] 10.3390/v14071441 PMC 바로가기 [Article Type] Article
Virucidal Properties of Photocatalytic Coating on Glass against a Model Human Coronavirus모델 인간 코로나바이러스에 대한 유리의 광촉매 코팅의 바이러스 살균 특성Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료제, [키워드] added aerosol alteration Antiviral antiviral activity can not coated with coating construction Contact Contagion Contamination coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 damaged deformation Disruption electron microscopy element Epidemiology Evidence evidence of exposure to glass human coronavirus human coronaviruses in-depth analysis inactivation increase infectious investigated Kinetics knowledge Masks Microscopy mitigate Model morphologically pandemic performed Photocatalysis photocatalytic coating physical physical barrier property Protective protective effect Protective effects reduced reducing Research SARS-CoV-2 Spread suggested surface titanium titanium dioxide Transmission viral envelope virion virions virucidal virucidal activity virus virus spread virus titer viruses [DOI] 10.1128/spectrum.00269-22 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamstersSARS-CoV-2 오미크론 변이체는 햄스터의 상부 및 하부 호흡기에서 가벼운 병리를 유발합니다Article Published on 2022-06-202022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alveolar cause caused changes in Coronavirus-2 Delta Gamma hamster hamsters Infection infectious virus titer infectious virus titers intranasal investigated lesion Lower respiratory tract lung Mild Olfactory epithelium omicron pathogenicity pathological pathology respiratory tissue respiratory tissues rhinitis RNA SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Strains Syrian golden hamster Syrian Golden hamsters upper and lower respiratory tract upper and lower respiratory tracts variant variants variants of concern Viral antigen virus spread VoC VOCs [DOI] 10.1038/s41467-022-31200-y PMC 바로가기 [Article Type] Article
Seroprevalence of COVID-19 in Riyadh city during the early increase of COVID-19 infections in Saudi Arabia, June 2020Research article Published on 2022-06-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 치료기술, [키워드] acute infections acute respiratory syndrome Asymptomatic blood donor Blood donors caused collected Complication coronavirus COVID-19 COVID-19 infection ELISA enzyme-linked immunosorbent evaluate evaluated global pandemic healthy blood donor highlight hospital Mild molecular mortality rate National non-COVID-19 patient pandemic Pandemics Patient Population populations positive sample reported SARS-CoV-2 Saudi Arabia SEROLOGICAL STUDY serological surveillance Seroprevalence serum sample virus spread [DOI] 10.1016/j.sjbs.2022.103282 [Article Type] Research article