Comparing the Impact of Road Networks on COVID-19 Severity between Delta and Omicron Variants: A Study Based on Greater Sydney (Australia) Suburbs델타 변종과 오미크론 변종 간의 COVID-19 심각도에 대한 도로망의 영향 비교: 광역 시드니(호주) 교외를 기반으로 한 연구Article Published on 2022-05-272022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종, [키워드] betweenness connection COVID-19 COVID-19 severity Delta delta variant dependent variables dominant Impact independent Infection measure Multiple linear regression network network analysis omicron Omicron variant Omicron variants predictor provide road statistical statistically significant suburb suburban road network. Transmission variant variants virus strain [DOI] 10.3390/ijerph19116551 PMC 바로가기 [Article Type] Article
The effectiveness of testing, vaccinations and contact restrictions for containing the CoViD-19 pandemic Research Published on 2022-05-162022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] change Contact Course develop Effect Effectiveness explain Factor Germany Government individuals Infection Initially Intervention pandemic positive profiles Quantitative reducing Spread the disease Transmission vaccination vaccination rate virus strain [DOI] 10.1038/s41598-022-12015-9 [Article Type] Research
Immunogenicity and safety of a third dose of CoronaVac, and immune persistence of a two-dose schedule, in healthy adults: interim results from two single-centre, double-blind, randomised, placebo-controlled phase 2 clinical trials건강한 성인에서 코로나백 3차 접종의 면역원성 및 안전성, 2회 접종 일정의 면역 지속성: 2건의 단일 센터, 이중 맹검, 무작위, 위약 대조 임상 2상 임상 시험의 중간 결과Clinical Trial Published on 2022-04-012022-09-12 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] 1:1 95% CI Abstract Administered Adverse reaction analysed antibody Antibody titre assigned Beijing booster dose China clinical trial clinical trials Cohort cohorts Concentration CoronaVac country Cutoff declined development dose doses double-blind eligible foundation GenBank accession number generate geometric geometric mean titre GMIs GMT GMTs groups healthy immune memory immune persistence immune response immunogenicity Inactivated vaccine increase increase in injection Jiangsu material natural neutralising antibody neutralising antibody titre Older outcome participant per-protocol population phase 2 trial Placebo placebo group placebo-controlled positive Program protocol amendment randomised Randomly recalled receive Registered reported resulting SARS-CoV-2 Science second dose Serious Adverse Event seropositive severity significantly increased technology threshold translation Trial vaccination vaccination against COVID-19 vaccination schedule Vaccine virus strain [DOI] 10.1016/S1473-3099(21)00681-2 PMC 바로가기 [Article Type] Clinical Trial
A Deadly Embrace: Hemagglutination Mediated by SARS-CoV-2 Spike Protein at Its 22 N-Glycosylation Sites, Red Blood Cell Surface Sialoglycoproteins, and AntibodyReview Published on 2022-02-252022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] α5-N-acetylneuraminic acid (Neu5Ac) ACE2 Betacoronavirus bind binding Blood CD147 clinical testing common cold COVID-19 COVID-19 patient enzyme Express expressed glycan glycophorin A hemagglutination hemagglutinin esterase host cell membrane host cells in silico in vitro Mediated MERS N-glycosylation site RBC RBCs Red red blood cell Release Replication SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein sialic acid spike Spike protein strain Strains surface therapeutic virulent virus virus strain [DOI] 10.3390/ijms23052558 PMC 바로가기 [Article Type] Review
Assessing the impact of SARS-CoV-2 prevention measures in Austrian schools using agent-based simulations and cluster tracing data에이전트 기반 시뮬레이션 및 클러스터 추적 데이터를 사용하여 오스트리아 학교에서 SARS-CoV-2 예방 조치의 영향 평가Article Published on 2022-01-272022-09-10 Journal: Nature Communications [Category] 변종, [키워드] agent Assessing Austrian schools Cluster Combination combinations community transmission Complex networks Computational science dominant epidemiological had more identify Intervention involved maintain Mask Masks mathematical mathematical model measure NPI NPIs open pandemic reduction SARS-CoV-2 School Schools Spread sustained the SARS-CoV-2 vaccination vaccination rates Vaccinations variant Ventilation viral infection virus strain [DOI] 10.1038/s41467-022-28170-6 PMC 바로가기 [Article Type] Article
SARS-CoV-2 variants with T135I nucleocapsid mutations may affect antigen test performanceT135I 뉴클레오캡시드 돌연변이가 있는 SARS-CoV-2 변이체가 항원 테스트 성능에 영향을 미칠 수 있음Article Published on 2022-01-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Amino acid amino acid substitutions Antigen antigen tests B.1.1.7 B.1.1.7 variant caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detect determine diagnostic Diagnostic method diagnostic testing Direct exhibiting false-negative False-negative result false-negative results Genome genomes GISAID isolate molecular Mutation mutations N protein negative and positive nucleocapsid Outbreaks PanBio pandemic Patient performed Prevent proliferation Protein Rapid rapid antigen test Rapid antigen tests respiratory reverse transcription PCR risk RT-PCR RT-PCR test SARS-CoV-2 SARS-CoV-2 variant Sequencing several variant several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 the N protein variant variants variations Viral virus strain was performed whole genome Whole genome sequencing [DOI] 10.1016/j.ijid.2021.11.006 PMC 바로가기 [Article Type] Article
Neutralization assays for SARS-CoV-2: Implications for assessment of protective efficacy of COVID-19 vaccinesArticle Published on 2022-01-012022-11-15 Journal: The Indian journal of medical research [Category] SARS, 변종, 진단, [키워드] Alpha variant Analysis Beta Beta variant COVID-19 vaccine Delta delta variant described dose Efficacy Final fold drop fold reduction Gamma Gamma variant generate in vitro inclusion criteria Laboratory Live virus neutralization Neutralization assay Neutralizing activity omicron platform Protective pseudovirus recipients Sample size SARS-CoV-2 SARS-CoV-2 isolates SARS-CoV-2 variant searched selected serum strain the WHO titre Vaccine vaccinees Variability variant variants variants of concern Variation virus strain VOCs WHO [DOI] 10.4103/ijmr.ijmr_2544_21 PMC 바로가기
Estimating the transmission advantage of the D614G mutant strain of SARS-CoV-2, December 2019 to June 20202019년 12월부터 2020년 6월까지 SARS-CoV-2의 D614G 돌연변이 균주의 전파 이점 추정Research Published on 2021-12-092022-09-10 Journal: Eurosurveillance [Category] SARS, 변종, [키워드] adjusted Amino acid Analysis applied basic reproduction number carried China Combination COVID-19 COVID-19 pandemic credible interval D614G D614G mutation disease disease control dominant variant effective epidemiological fitness Intervention less MONITOR mutant mutant strain Mutant strains Mutation mutation D614G mutations pandemic Phylogenetic phylogenetics Result SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 surveillance sequence Spread strain Surveillance Transmissibility Transmission Transmission advantage Treatment Vaccine variant of concern variants of concern virus strain wildtype [DOI] 10.2807/1560-7917.ES.2021.26.49.2002005 PMC 바로가기 [Article Type] Research
Hotspot Mutations in SARS-CoV-2Genetics Published on 2021-11-292022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] acute respiratory syndrome addition amino acid change Analysis calculated carried Characteristics coding region Coronavirus-2 country COVID-19 Deletion deletions Entropy Evolution example functional consequence global pandemic greater hotspot hotspot mutations human Ace2 protein L452R MAFFT Missense mutations Multiple sequence alignment Mutation mutations N501Y Non-synonymous Patient performed Phylogenetic analysis Protein resulting SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 sequence sequence spike Spread Structure Substitution T478K the binding affinity the receptor-binding domain unique vaccination variants of concern virus virus strain Wuhan, China [DOI] 10.3389/fgene.2021.753440 PMC 바로가기 [Article Type] Genetics
Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus InfectionArticle Published on 2021-11-282022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] ACSL1 administration ameliorated Apoptosis approach C57BL/6 caused Cell coronavirus Coronavirus infection expression Ferroptosis Genes Hepatitis Host hyper-inflammation in vivo indicate induce inducer infected cells Infection Inflammatory cytokine inhibited inhibitor intranasal involved Lung inflammation lytic cell death Macrophage macrophages MHV-A59 mice mouse hepatitis virus (MHV) murine necroptosis pathogenicity performed Potential treatment PROTECT pyroptosis released RNA-Seq shown suppressed Syncytia syncytia formation targeting therapy tissue injury TLR4 upregulate upregulation viral propagation virus strain [DOI] 10.3390/v13122383 PMC 바로가기 [Article Type] Article