Serosurvey in SARS-CoV-2 inactivated vaccine-elicited neutralizing antibodies against authentic SARS-CoV-2 and its viral variantsArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Administered Antibody neutralization BBIBP-CorV Beta booster vaccination circulating CoronaVac coronavirus Delta Eta Gamma humoral immune response immune immune response inactivated Inactivated vaccine individual Lineage lineages morbidity and mortality Mutation neutralization neutralization titer neutralize neutralized Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody response omicron reduce SARS-CoV-2 SARS-CoV-2 variant second vaccination serum sample significantly lower the SARS-CoV-2 vaccine dose variant viral variant Viral variants virus virus strain viruses wild-type [DOI] 10.1002/jmv.28049 PMC 바로가기
Humoral immune response to authentic circulating severe acute respiratory syndrome coronavirus 2 variants elicited by booster vaccination with distinct receptor-binding domain subunits in mice생쥐에서 뚜렷한 수용체 결합 도메인 소단위로 부스터 백신 접종에 의해 유도된 진정한 순환 중증 급성 호흡기 증후군 코로나바이러스 2 변이체에 대한 체액 면역 반응Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antibody titer Antibody titers binding booster booster vaccination circulating comparable coronavirus coronavirus disease Coronavirus disease 2019 domain dose Efficacy elicited expected humoral immune response Immune escape immune response immunization immunogens induce mice Mutation Neutralizing antibody titer neutralizing antibody titers omicron Protein RBD RBD protein respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly increased Spike protein subunit the spike protein Vaccine vaccine efficacy variant variants virus strain virus strains wild type [DOI] 10.1002/jmv.27882 PMC 바로가기 [Article Type] Article
Debulking different Corona (SARS-CoV-2 delta, omicron, OC43) and Influenza (H1N1, H3N2) virus strains by plant viral trap proteins in chewing gums to decrease infection and transmissionArticle Published on 2022-09-012022-11-15 Journal: Biomaterials [Category] COVID19(2023년), SARS, 신종인플루엔자, 치료기술, [키워드] Chewing clinical trial Corona Debulking decrease dose-dependent double-blinded evaluate expressed H1N1 H3N2 HCoV-OC43 IND Infection Influenza investigated linear magnitude N-antigen nasal nasopharyngeal OC43 overlapping Particle phase placebo-controlled plant cells Protein purified reduced reduction Saliva SARS-CoV-2 delta significantly Spike protein strain Transmission transmission of SARS-CoV-2 Viral load virus virus load virus strain [DOI] 10.1016/j.biomaterials.2022.121671 PMC 바로가기
A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 InfectionSARS-CoV-2 감염에 대한 항바이러스제의 효능을 평가하기 위한 SCID 마우스 모델Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 치료제, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral drug antiviral drugs antiviral efficacy antivirals B.1.351 B.1.351 variant BALB/c Beta Beta variant binding C57BL/6 CAGE coronavirus Culture drug hamsters Infection infectious virus titer infectious virus titers Infective dose inhibitors intrinsic lack log lung Lung pathology Lungs male mice Model moderate molnupiravir mouse mouse model Mouse models Nirmatrelvir offer Postinfection reagent receptor reduced replicate Replication reported SARS-CoV-2 SARS-CoV-2 mouse model SARS-CoV-2 strain SARS-CoV2 SCID significantly TCID These data tissue tissue culture twice a day Validity variant variants variants of concern Viral load virus virus strain wild-type [DOI] 10.1128/jvi.00758-22 PMC 바로가기 [Article Type] Article
Heterologous immunity induced by 1st generation COVID-19 vaccines and its role in developing a pan-coronavirus vaccineArticle Published on 2022-08-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] acute respiratory syndrome adaptive addition COVID-19 COVID-19 pandemic COVID-19 vaccine cross-reactive develop Evolution Heterologous heterologous immunity highlight Hospitalization illnesses Immunity immunization individual Infection mechanism Mortality MOST mutated mutated variant other coronaviruses pan-coronavirus vaccine pandemic Prevent PROTECT protective role Protein SARS-CoV-2 SARS-CoV-2 antigens T cell the Spike understanding universal vaccine development. Vaccine Vaccine development variant viral strains virulent virus strain [DOI] 10.3389/fimmu.2022.952229 PMC 바로가기
Phylogenetic analysis of human parainfluenza type 3 virus strains responsible for the outbreak during the COVID-19 pandemic in Seoul, South KoreaResearch article Published on 2022-08-012022-10-05 Journal: Journal of Clinical Virology [Category] 변종, [키워드] Acute respiratory infection aligned amino acid sequence analyses Analysis bootstrap C3a C3c cause Characteristics children circulating Cluster collected COVID-19 pandemic Emerging lineages Epidemic gene sequence Genetic Human Human Parainfluenza Virus 3 Infant Lineage molecular mutations nasopharyngeal swab specimen nucleotide sequence outbreak parainfluenza parainfluenza virus 3 Phylogenetic Phylogenetic analysis potential risk Protein ranged respiratory pathogen responsible Result South Korea specimens strain Substitution Support unique virus strain [DOI] 10.1016/j.jcv.2022.105213 [Article Type] Research article
Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructuresSARS-CoV-2 스파이크 단백질과 DNA-펩티드 나노구조의 결합 상호작용 특성 규명Article Published on 2022-07-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Amino acid amino acid sequence analyte angiotensin angiotensin converting enzyme Beta binding binding interaction binding interactions binding modes capture characterization complement concentrations Corona virus DNA ELISA enzyme full-length spike protein geometric hACE2 immunosorbent inactivated increase in Interaction investigated moiety mono peptide Protein binding quantified Quantitative RBD receptor SARS-CoV-2 SARS-CoV-2 spike protein sequence Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus shown Spike protein Spike proteins subunit subunits tested the spike protein trimeric trivalent variant variations virus virus strain viruses while wild type [DOI] 10.1038/s41598-022-16914-9 PMC 바로가기 [Article Type] Article
Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission Research Published on 2022-07-072022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] clinical testing Community Concentration Critical detect effort estimate Factor genomic genomic sequence High-resolution IMPROVE Infection instance less limit Lineage Prevalence protocol provide Public health interventions resources reveal SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant sequence Sequencing Spread Surveillance Transmission variant variants variants of concern virus virus spread virus strain wastewater [DOI] 10.1038/s41586-022-05049-6 [Article Type] Research
Duration of infectious viral shedding in patients with mild to moderate COVID-19 treated with REGN-CoV2REGN-CoV2로 치료받은 경증 내지 중등도의 COVID-19 환자에서 감염성 바이러스 배출 기간Article Published on 2022-07-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral effect approved caused Clinical course Clinical efficacy collected coronavirus coronavirus disease COVID-19 Culture Delta delta variant drug Duration effective Efficacy groups Hiroshima Infection inhibitory concentration investigated Isolation Mild Mild disease mild to moderate mild to moderate disease Moderate COVID-19 moderate disease New Patient patients with COVID-19 PCR testing performed Pharyngeal swab reduced REGN-CoV2 respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly shorter Spread strain study period treated Treatment treatment methods university Viral viral culture viral mutation Viral mutations viral shedding virus virus culture virus strain with mild disease [DOI] 10.1016/j.jiac.2022.03.013 PMC 바로가기 [Article Type] Article
Characterisation of SARS-CoV-2 clades based on signature SNPs unveils continuous evolution시그니처 SNP를 기반으로 한 SARS-CoV-2 분기군 특성화, 지속적인 진화 공개Article Published on 2022-07-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] A97V Amino acid amino acid change amino acid changes biological function Biological functions carried change changes in Characteristics clade clades Cluster COVID-19 cure dataset Deleterious Deleterious mutations evaluate Evolution form Frequency globe identify MAFFT Multiple sequence alignment Mutation Nextstrain Non-synonymous Non-Synonymous Signature SNP NSP2 nsp4 nucleocapsid Occurrence ORF3a performed phylogenetic analyses Phylogenetic analysis PolyPhen-2 Protein protein structure PROVEAN Q57H RdRP Research responsible SARS-CoV-2 SARS-CoV-2 genome sequence Sequence alignment sequences signature SNP SNPs Spread stability strain T85I unique unique SNP unique SNPs used to evaluate vaccination Vaccine virus virus genome virus strain virus strains Wuhan Wuhan, China [DOI] 10.1016/j.ymeth.2021.09.005 PMC 바로가기 [Article Type] Article