Low Levels of Few Micronutrients May Impact COVID-19 Disease Progression: An Observational Study on the First WaveArticle Published on 2021-08-242022-10-30 Journal: Metabolites [Category] COVID-19, [키워드] 95% CI Admission Adult patient age analysed association clinical trial coronavirus COVID-19 Critical illness Culture Gender greater Hospital admission HPLC ICU ICU admission immunoassay Impact intubation Level male mean value Micronutrient micronutrients Mortality Nasopharyngeal swab Older outcome pandemic Patient PCR performed plasma analysis positive SARS-CoV-2 severe COVID-19 patient Spanish standard error the SARS-CoV-2 trace elements tracheal Treatment university hospital variable Vitamin vitamin A Vitamin C vitamins Wave [DOI] 10.3390/metabo11090565 PMC 바로가기 [Article Type] Article
A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorderArticle Published on 2021-08-232023-06-18 Journal: Cellular signalling [Category] MERS, SARS, [키워드] Akt, serine/threonine specific protein kinase B ATRA, All-trans retinoic acid Autoimmunity BALF, bronchoalveolar lavage fluid c-Myc, cellular Myc proto-oncogene CDC, Centers for Disease Control and Prevention cisRA, cis isomers of retinoic acid COVID-19 COVID-19, Coronavirus disease 2019 CRABP-1, cytoplasmic retinoic acid binding protein 1 CRBP-I, cytoplasmic retinol binding protein 1 CXCL9, C-X-C motif chemokine ligand 9 CYP26, cytochrome P450 family 26 CYP27, cytochrome P450 family 27 CYP450 CYP450, cytochrome P450 superfamily of enzymes Erk, extracellular-signal-regulated kinase FOXP3 FoxP3, Forkhead box P3 transcription factor GluR1, glutamate receptor 1 IFN, interferon IL, interleukin cytokines IL2RA, interleukin 2 receptor-alpha subunit Inflammation IRF, interferon-regulatory factors JAK, Janus kinases Lyn, Lyn protein kinase, a member of Src family tyrosine kinases MAPK, Mitogen-activated protein kinase MDA5, Melanoma differentiation-associated protein 5 NCoA, nuclear receptor co-activators NCoR, nuclear receptor co-repressors NF-κB NF-κB, nuclear factor kappa light chain enhancer of activated B cells PI3K, Phosphatidylinositol-3-kinase PPAR, Peroxisome proliferator-activated receptor PRR, Pattern Recognition Receptors RA, retinoic acid RALDH, retinaldehyde dehydrogenase enzyme RAR, retinoic acid receptors RARE, retinoic acid response elements (regulatory DNA sequences bound by retinoic acid receptors) RBP, retinol binding protein RDH, retinol dehydrogenase enzymes retinoic acid Retinoid signaling retinol RIG-I RIG-I, retinoic acid-inducible gene-I RLR, RIG-I-like receptor RORγt RORγt, Retinoic acid-related orphan receptor gT transcription factor RXR, retinoid X receptors SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 sST2, soluble suppression of tumorigenicity 2 STAT, Signal transducer and activator of transcription sTNFRSF1A, soluble TNF receptor superfamily member 1A STRA6, signaling receptor and transporter of retinol TGF-β, Transforming growth factor-beta Th17 Th17, T helper 17 cells TLR, toll-like receptors TNF, Tumor Necrosis Factor TRAF, TNF receptor (TNF-R)-associated factor Treg Treg, regulatory T cells Type-I IFN Type-I IFN, Type I interferon (IFN-α and IFN-β) VAD, vitamin A deficiency VitA, vitamin A vitamin A Vitamin D VitD, vitamin D WHO, World Health Organization [DOI] 10.1016/j.cellsig.2021.110121 PMC 바로가기 [Article Type] Article
Liver Damage and Exposure to Toxic Concentrations of Endogenous Retinoids in the Pathogenesis of COVID-19 Disease: HypothesisReviews Published on 2021-08-012022-10-28 Journal: Viral immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome appear association blood vessel blood vessels Brain cause circulation cirrhosis closely resemble concentrations coronavirus COVID-19 COVID-19 disease damage disease effective endogenous Evidence exposure to hepatocyte Hypothesis include Inflammatory Inflammatory response liver Liver damage lung Lungs manifestation metabolic syndrome organ Pathogenesis pathology prevention of COVID-19 Protein released responsible resulting retinoid retinoids retinyl ester reveal review SARS-CoV-2 Sepsis Support tissue damage toxic Treatment virus vitamin A [DOI] 10.1089/vim.2020.0330 PMC 바로가기 [Article Type] Reviews
Clinical characterization and therapeutic targets of vitamin A in patients with hepatocholangiocarcinoma and coronavirus disease간도 콜랑 지오 마쇄종 및 코로나 바이러스 질환 환자에서 비타민 A의 임상 적 특성 및 치료 적 표적Research Paper Published on 2021-06-302022-09-10 Journal: Aging (Albany NY) [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] Anti-inflammatory anti-inflammatory actions Anti-viral approach Bioinformatics analysis BRD2 CDK4 Cell Characteristics clinical Clinical finding Clinical findings Clinical management contribute coronavirus coronavirus disease COVID-19 CXCR3 database determine function genome analysis GPT hepatocholangiocarcinoma ICAM1 identify Immunity immunopotentiation inflammatory reaction MAPK1 mechanism mechanism of action Medicine molecular functions molecular mechanism molecular mechanisms morbidity and mortality mortality rate network pharmacology NOS2 oxidative stress Pathways Patient patients with COVID-19 pharmacological Potential treatment Prognosis recent recurrence Signaling suppression survival rate susceptibility target therapeutic therapeutic target TMPRSS13 Transcriptome Vitamin vitamin A were used [DOI] 10.18632/aging.203220 PMC 바로가기 [Article Type] Research Paper
Vitamin A Plasma Levels in COVID-19 Patients: A Prospective Multicenter Study and HypothesisCOVID-19 환자의 비타민 A 혈장 수준: 전향적 다기관 연구 및 가설Observational Study Published on 2021-06-242022-09-10 Journal: Nutrients [Category] MERS, SARS, 바이오마커, 임상, [키워드] Acute inflammation acute respiratory distress syndrome acute SARS-CoV-2 infection analyzed ARDS cause control group convalescent correlated COVID-19 COVID-19 patient Critical disease Critically ill cross-sectional cross-sectional study CRP determined by ECMO extracorporeal membrane oxygenation ferritin high-performance liquid chromatography hospitalized patient hospitalized patients hyperinflammation immune function immune functions infected with SARS-CoV-2 Inflammation Inflammatory marker inflammatory markers LDH Level Liquid chromatography lymphocyte Lymphocyte count marker membrane moderate disease Mortality multicenter multicenter study oxygen oxygen supplementation Oxygenation pandemic pandemic disease plasma Plasma levels Pneumonia Prospective pulmonary damage reduced respiratory respiratory distress Respiratory distress syndrome retinoic acid retinol SARS-CoV-2 SARS-CoV-2 infected individuals SARS-COV-2 infection severe disease significantly significantly lower Vitamin vitamin A [DOI] 10.3390/nu13072173 PMC 바로가기 [Article Type] Observational Study
Pathophysiology and possible treatments for olfactory-gustatory disorders in patients affected by COVID-19Review article Published on 2021-06-052022-10-05 Journal: Current Research in Pharmacology and Drug Discovery [Category] 치료법, [키워드] ACE2 ACE2 receptor addition affected Ageusia alveolar epithelial cell alveolar epithelial cells Anosmia approach Bronchial epithelium cause changes in Clinical management co-expression COVID-19 decrease described disorder disorders effective therapy Evidence expressed gastrointestinal tract host cell implication include infect influence Interaction intranasal involved knowledge Loss of Smell mechanism nasal olfactory olfactory disorder olfactory dysfunction omega-3 pathophysiology Patient patients with COVID-19 pharmacological Protein receptor SARS-CoV-2 sensitivity sensory neuron shown sialic acid Smell sodium specific treatment spike Taste Therapeutics therapy TMPRSS2 transmembrane serine protease treat Treatment virus vitamin A [DOI] 10.1016/j.crphar.2021.100035 [Article Type] Review article
Neurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory DysfunctionCase Report Published on 2021-05-232022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] Combination coronavirus disease correlated COVID-19 functional network Neurosensory olfactory olfactory bulb olfactory dysfunction one patient Patient rehabilitation resting-state fMRI smell training Treatment vitamin A Volume [DOI] 10.3390/brainsci11060686 PMC 바로가기 [Article Type] Case Report
Nutritional approach for increasing public health during pandemic of COVID-19: A comprehensive review of antiviral nutrients and nutraceuticalsReview Published on 2021-05-192022-10-31 Journal: Health Promotion Perspectives [Category] COVID-19, [키워드] accompanied Alpha Antiviral approach boost clinical manifestation coronavirus COVID-19 COVID-19 patients Critical database decrease dietary intake Effect Electrolytes Energy intake English fatty acids Google Scholar host immunity immune function Immunity Infection life-threatening linolenic acid maintain Malnutrition management mechanism Micronutrient Minerals Novel coronavirus nutraceutical nutritional status obesity Omega-3 Vitamins pandemic pandemic disease Pathogenesis physical activity Proteins provided public health required respiratory viral infection severe respiratory infection vitamin A Vitamin C vitamins [DOI] 10.34172/hpp.2021.17 PMC 바로가기 [Article Type] Review
COMPARE Analysis, a Bioinformatic Approach to Accelerate Drug Repurposing against Covid-19 and Other Emerging EpidemicsResearch article Published on 2021-03-012022-10-05 Journal: SLAS discovery : advancing life sciences R & D [Category] SARS, 신약개발, 치료제, [키워드] Algorithm Analysis Anti-SARS-CoV-2 Activity Antibiotics Antiviral antiviral activity approach Bioinformatic bioinformatics cancer cell lines COMPARE analysis Compound COVID-19 described Dexamethasone drug Drug discovery Drug repurposing drugs growth Hydroxychloroquine in silico In silico methods include inhibitory methotrexate National Cancer Institute nicotinamide nucleosides Other Outbreaks pharmacological profile Repository repurposing resource Ritonavir SARS-CoV-2 structures tested uridine viral epidemics vitamin A vitamins were used [DOI] 10.1177/2472555220975672 [Article Type] Research article
Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and MetabolismReview Published on 2021-01-302022-10-31 Journal: Nutrients [Category] COVID-19, [키워드] Action activating Anti-inflammatory Compound coronavirus COVID-19 deleterious effect disease fatty acids healthy Hypothesis implicated Inflammation inhibitor investigated Mediterranean diet Micronutrient Minerals morbidity and mortality New coronavirus nutritional status omega-3 PAF PAF-inhibitors pandemic pathogenesis of COVID-19 pathophysiology Patient phytochemical Platelet platelet activating factor Potential Prevent robust role suggested thrombosis vitamin A Vitamin C [DOI] 10.3390/nu13020462 PMC 바로가기 [Article Type] Review