Humoral response among patients with interstitial lung disease vaccinated with the BNT162b2 SARS-Cov-2 vaccine: a prospective cohort studyObservational Study Published on 2022-09-012022-10-05 Journal: Respiratory Research [Category] SARS, 임상, 진단, [키워드] addition age and sex Anti-inflammatory Anti-inflammatory therapy anti-inflammatory treatments Anti-spike antibody Antibody titer antifibrotic therapy BNT162b2 BNT162b2 vaccine caused Cohort conducted control group dose evaluate evaluated healthy control high risk humoral Humoral response ILD immune response Immunosuppression Interstitial lung disease IPF maintain median Messenger RNA Patient patients patients treated patients with ILD prospective cohort study pulmonary fibrosis Rabin Medical Center SARS-CoV-2 vaccine serology test seronegative seropositive Severe COVID-19 Infection significantly lower the healthy therapy treated Treatment vaccination vaccine dose was reduced [DOI] 10.1186/s12931-022-02155-x PMC 바로가기 [Article Type] Observational Study
Decreased Passive Immunity to Respiratory Viruses through Human Milk during the COVID-19 PandemicArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] 진단, [키워드] antibodies antibody association binding breast milk circulation consequence Coronaviruses COVID-19 COVID-19 pandemic decrease Decreased develop explain HCoV-HKU1 HCoV-NL63 HCoV-OC43 help Hospital admission Hospitalization Human human milk Humoral immunity hygiene IgA IgG IgG level immune system Immunity Infant Infants Infection infections Influenza lifted lockdown Luminex assay measure milk mother pandemic Passive passive immunity predict Prevent preventative measure preventative measures provide reduced respiratory respiratory infections respiratory syncytial virus respiratory virus resulting RSV seasonal coronavirus serum subsequent viral respiratory virus viruses was reduced [DOI] 10.1128/spectrum.00405-22 PMC 바로가기
Translational feasibility and efficacy of nasal photodynamic disinfection of SARS-CoV-2SARS-CoV-2의 비강 광역학 소독의 번역 타당성 및 효능Clinical Trial Published on 2022-08-242022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 임상, 치료법, [키워드] Antiviral treatment Bacterial Betacoronavirus clinical trial contributed COVID-19 dependent on early stage early stages Effect effective Effective vaccines Efficacy feasibility global pandemic human betacoronavirus in vitro in vitro result in vitro results inactivation Infection investigated lack Local Methylene Methylene blue nare nares nasal not dependent OC43 Pathogens Perspective photodynamic therapy practicality principle qPCR Quantitative reduce RNA RT-qPCR Safe SARS-CoV-2 SARS-CoV-2 viral load Swab therapeutic option therapeutic options therapy undetectable variants variety viral infectivity viral pathogen viral pathogens Viral RNA virus was reduced [DOI] 10.1038/s41598-022-18513-0 PMC 바로가기 [Article Type] Clinical Trial
Effects of surgical and FFP2 masks on cardiopulmonary exercise capacity in patients with heart failureRandomized Controlled Trial Published on 2022-08-232022-10-05 Journal: PLoS ONE [Category] SARS, 임상, [키워드] activity Adults age Cardiopulmonary changed chronic heart failure clinically cross-over discomfort Effect Ejection fraction Exercise capacity facemask healthy heart failure LVEF Mask maximum oxygen uptake Patient patients peak ventilation quantified questionnaire Randomized reduce reduction in sequence significantly significantly increased surgical transmission of SARS-CoV-2 ventricular was reduced [DOI] 10.1371/journal.pone.0269470 PMC 바로가기 [Article Type] Randomized Controlled Trial
Evaluation of serological response to anti-SARS-CoV-2 mRNA vaccination in hematological patients혈액학적 환자에서 anti-SARS-CoV-2 mRNA 백신접종에 대한 혈청학적 반응 평가Article Published on 2022-08-082022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] Administered anti-SARS-CoV-2 anti-SARS-CoV-2 IgG anti-SARS-CoV-2 vaccination Anti-spike anti-Spike IgG anti-spike IgG level antibody Antibody titer association Cell Cohort cohort of patient Concentration control arm control group Cutoff demographic variable difference drug Effect evaluated greater health worker healthy healthy subjects hematological Hematological malignancies Hematological malignancy heterogeneous highest identify IgG IgG titer immune system immunoassay Immunocompromised patients Immunosuppression implication inhibitor Italy leukemia Microparticle molecular mRNA mRNA vaccination mRNA vaccine onco-hematology. parameter pathology Patient patients performed Predictive reached reduced reported SARS-CoV-2 SARS-CoV-2 antibody second dose seroconversion rate serological response shown significantly lower spike IgG statistical significance steroid stratified Surveillance the mean the patient Therapies therapy treated tyrosine underlying disease vaccination Vaccine was reduced [DOI] 10.3389/fimmu.2022.892331 PMC 바로가기 [Article Type] Article
Rheumatoid arthritis patients treated with Janus kinase inhibitors show reduced humoral immune responses following BNT162b2 vaccinationJanus kinase inhibitor로 치료받은 류마티스 관절염 환자, BNT162b2 백신 접종 후 체액성 면역 반응 감소Article Published on 2022-08-032022-09-12 Journal: Rheumatology (Oxford, England) [Category] SARS, 진단, [키워드] Activation alteration analysed anti-spike antibodies anti-Spike IgG Anti-spike IgG antibody antibodies antibody antibody titres Arthritis B cell B cell responses B cells B-lymphocytes BNT162b2 BNT162b2 vaccine collected COVID-19 COVID-19 vaccine determine dose Efficacy elicited ELISA expression germinal centre healthy individual healthy individuals humoral humoral immune response Humoral immunity IgA antibody individuals JAK inhibitor Janus kinase Janus kinase inhibitor Janus kinase inhibitors less mRNA-based COVID-19 vaccine neutralization activity Neutralization assay neutralization capacity Patient patients patients treated plasma plasma sample quantitative PCR reduced Rheumatoid rheumatoid arthritis SARS-CoV-2 SARS-COV-2 infection shown Spike protein suppressed the SARS-CoV-2 the vaccine titre treated vaccination Vaccine Vaccines Virus neutralization was reduced was used [DOI] 10.1093/rheumatology/keab879 PMC 바로가기 [Article Type] Article
Identification of conserved regions from 230,163 SARS-CoV-2 genomes and their use in diagnostic PCR primer design230,163 SARS-CoV-2 게놈에서 보존 영역 식별 및 진단 PCR 프라이머 디자인에서의 사용Article Published on 2022-08-012022-09-11 Journal: Genes & genomics [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] addition Alpha amplification approach Beta bioinformatics can be used candidate Candidates characteristic conserved Coverage dataset Delta Diagnosis diagnostic Epsilon Eta evaluated exhibited False negative full-length Gamma genome sequence genomes genomic sequence GISAID GISAID EpiCoV database identification identify in silico Intensive Iota Multiple Multiple sequence alignment multiple sequence alignments NCBI nine NSP2 orf3a gene Outbreaks pandemic PCR PCR primer primer primer set primer sets Primers qPCR RdRP Region removal retrieved RNA sample RNA samples RT-qPCR S gene SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 variant sequence Sequence alignment target viral genome viral sequences was reduced Zeta [DOI] 10.1007/s13258-022-01264-7 PMC 바로가기 [Article Type] Article
Effects of lower screening activity during the COVID-19 pandemic on breast cancer patient pathways: Evidence from the age cut-off of organized screening유방암 환자 경로에 대한 COVID-19 범유행 기간 동안 낮은 검진 활동의 영향: 조직 검진의 연령 제한에서 증거Article Published on 2022-08-012022-09-11 Journal: Health policy (Amsterdam, Netherlands) [Category] 치료제, [키워드] age Breast Breast cancer Breast cancer incidence Breast cancer screening Cancer Cancer screening catch caused Combination COVID-19 COVID-19 pandemic cut-off diagnose Diagnosis dropped early diagnosis Effect examined Factors Hungary information mastectomy no significant difference offset old age organized pandemic Partial Partial mastectomy Patient reduction Regression Regression discontinuity. screenings seasonality significant difference Suspension target population Treatment was reduced [DOI] 10.1016/j.healthpol.2022.05.013 PMC 바로가기 [Article Type] Article
Changes in Some Vascular Biomarkers in Patients with Severe COVID-19 with Various Degrees of Pulmonary HypertensionArticle Published on 2022-08-012022-11-15 Journal: Bulletin of experimental biology and medicine [Category] 바이오마커, [키워드] Biomarker BNP change changes in Course COVID-19 COVID-19 in patient degree evaluate group metabolism N-terminal Nitrate nitrite NO NP-proBNP NT-proBNP parameter Patient patients receiving oxygen patients with COVID-19 peptide Pneumonia pro-B-type natriuretic peptide pulmonary pulmonary hypertension reduced therapy two group was reduced [DOI] 10.1007/s10517-022-05581-5 PMC 바로가기
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational studyObservational Study Published on 2022-08-012022-10-04 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] age analysed approach association Characteristics clinical Clinical outcome clinical trials Cluster cluster analysis Clustering Clusters Cognitive impairment Cohort comparison Concentration COVID COVID-19 described discharge discharged domains effective Factor female full recovery Health hospital Hospital admission hospital discharge hospitalisation identify IL-6 improvement Inflammation Inflammatory inflammatory mediator Innovation Intervention Invasive mechanical ventilation ISRCTN registry less logistic regression modelling longitudinal cohort study median men mental health Mild moderate obesity Odds ratio organ function outcome measure outcome measures participant Participants Patient pharmacological PHOSP-COVID physical plasma Post-hospitalisation COVID-19 study potential therapeutic target profile proportion prospective observational study Protein Quality of life recruitment Registered reported retrospective severity Sex stratified tissue damage treatable utility was done was increased was performed was reduced were assessed WHO with COVID-19 women [DOI] 10.1016/S2213-2600(22)00127-8 PMC 바로가기 [Article Type] Observational Study