Will SARS-CoV-2 Infection Elicit Long-Lasting Protective or Sterilising Immunity? Implications for Vaccine Strategies (2020)Immunology Published on 2020-12-092022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Adaptive immune response Course COVID-19 Critical Evidence global pandemic Human immune system immune response Immunity immunogenicity immunological characteristics implication Infection knowledge long-lasting memory response Novel coronavirus outbreak pandemic Protective protective immunity question raising Reinfection reported SARS-CoV SARS-CoV-2 Sterilising Strategy the disease Vaccine Vaccine development virus Wuhan, China [DOI] 10.3389/fimmu.2020.571481 PMC 바로가기 [Article Type] Immunology
Mechanisms of Dysregulated Humoral and Cellular Immunity by SARS-CoV-2Review Published on 2020-12-082022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Activation acute respiratory syndrome adaptive Adaptive immune response Adaptive immunity B and T cell immune response caused Cell China coronavirus disease COVID-19 Defense disease disease severity immune response Immunity innate immune response mechanism memory B Mortality Neutralizing antibody titer pandemic Patient patients Re-infection response SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 patients severe SARS-CoV-2 T cell viral clearance virus while [DOI] 10.3390/pathogens9121027 PMC 바로가기 [Article Type] Review
COVID-19 susceptibility in pregnancy: Immune/inflammatory considerations, the role of placental ACE-2 and research considerations임신 중 COVID-19 감수성: 면역/염증 고려사항, 태반 ACE-2의 역할 및 연구 고려사항Article Published on 2020-12-012022-09-12 Journal: Reproductive biology [Category] MERS, 진단, [키워드] ACE-2 ACE2 ACE2 receptor Adaptive immune response angiotensin-converting enzyme 2 Asymptomatic individuals concerning COVID-19 COVID-19 susceptibility disease pathology disease severity Endothelial cell explain highlight immune response Immunity Inflammation molecular new virus outcomes pathogenesis of COVID-19 Perspective physiological Placenta placental Pregnancy pregnant women question receptor Research SARS CoV-2 SARS-CoV-2 Serological testing stimulate susceptibility the SARS-CoV-2 virus widespread would increase [DOI] 10.1016/j.repbio.2020.10.005 PMC 바로가기 [Article Type] Article
Impact of Diabetes in Patients Diagnosed With COVID-19Immunology Published on 2020-12-012022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress Adaptive immune response affected affecting angiotensin converting enzyme2 (ACE2) ARDS cardiovascular disease caused characterized Complication contagious contribute coronavirus disease (COVID-19) Coronavirus infection coronavirus SARS-CoV-2 country COVID-19 death diabete diabetes Diabetes Mellitus diagnosed disease Elderly patient Factor furin higher risk hyperglycemia hypertension Impact increased risk individual infections interferon induced membrane (IFITM3) low-grade inflammation mechanism metformin morbidity Mortality obese obesity pathophysiology pathway Patient respiratory risk SARS patient SARS-CoV-2 serine 2 (TMPRSS2) susceptibility syndrome transmembrane protease Transmission Treatment type 2 diabetes virus [DOI] 10.3389/fimmu.2020.576818 PMC 바로가기 [Article Type] Immunology
COVID-19: The Emerging Immunopathological Determinants for Recovery or DeathMicrobiology Published on 2020-12-012022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] activated Adaptive immune response adaptive immune system antibodies B cell response COVID-19 Critical Critically ill patient death in COVID-19 Deterioration determinant determine develop disease effective functional heterogeneous Host host cell host immune system immune immune response immune system immunopathological imperative implicated Infection initial interferon response involved knowledge lymphocytopaenia mechanism molecular outcome pathway Patient patients respiratory virus SARS-CoV-2 severe disease Stage Symptom T cell T cell response therapeutic interventions viral clearance viral evasion virus [DOI] 10.3389/fmicb.2020.588409 PMC 바로가기 [Article Type] Microbiology
Evasion of the Cell-Mediated Immune Response by AlphaherpesvirusesReview Published on 2020-11-262024-09-02 Journal: Viruses [Category] 대상포진, [키워드] Adaptive immune response alphaherpesvirus herpesviral evasion [DOI] 10.3390/v12121354 PMC 바로가기 [Article Type] Review
Negative Clinical Evolution in COVID-19 Patients Is Frequently Accompanied With an Increased Proportion of Undifferentiated Th Cells and a Strong Underrepresentation of the Th1 SubsetImmunology Published on 2020-11-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation Adaptive immune response affected Analysis Blood CD38 CD4+ CD8 CD8+ CD8+ T cell Cell characterized clinical COVID-19 COVID-19 patient Critical decrease donors effective explain Express Factor Frequency Frequently high-risk population HLA-DR immune profiling Increased Inflammatory innate response lymphocyte lymphopenia marker multiparametric flow cytometry negative outcome Patient performed Peripheral blood SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 severe coronavirus disease 2019 severity Strong subset T cell T cell response T cells T cells response T helper T lymphocyte T-CD8 lymphocytes flow cytometric immunophenotyping Th cell Th lymphocytes Th1 Th1 cell Th1/Th17 Th17 Undifferentiated virus infection virus load [DOI] 10.3389/fimmu.2020.596553 PMC 바로가기 [Article Type] Immunology
Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19Article Published on 2020-11-232023-06-18 Journal: Cell [Category] Fulltext, SARS, [키워드] Adaptive immune response COVID-19 Human memory B cell memory T cell monoclonal antibody SARS-CoV2 Vaccine [DOI] 10.1016/j.cell.2020.11.029 PMC 바로가기 [Article Type] Article
Vitamin D3 as Potential Treatment Adjuncts for COVID-19Review Published on 2020-11-142022-10-31 Journal: Nutrients [Category] COVID-19, SARS, [키워드] “cytokine storm” Activation Acute respiratory infection acute respiratory syndrome Adaptive immune response adjunct ARDS cause characterized clinical trial coronavirus COVID-19 Critical distress drug dysregulation effort Health Host immune response IL-1 IL-6 immune activation immunomodulation immunomodulatory Infection Infectious disease inflammatory process Innate immunity mechanism Meta-analysis observational study pandemic Potential prevention promote Protective receptor risk SARS-CoV2 SARS-CoV2 immunopathology SARS-CoV2 infection significant increase supported syndrome systemic hyperinflammation therapy Vaccine VDR viral infection Vitamin D Vitamin D receptor Vitamin D supplementation Vitamin D3 [DOI] 10.3390/nu12113512 PMC 바로가기 [Article Type] Review
Immune life history, vaccination, and the dynamics of SARS-CoV-2 over the next 5 yearsResearch Article Published on 2020-11-132022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS, [키워드] active infection acute respiratory syndrome adaptive Adaptive immune response assumption coronavirus coronavirus disease Coronaviruses COVID-19 COVID-19 cases Critical cross-reactions disease Efficacy elicited Epidemics epidemiological estimate feature highlight Human immune immune response Immunity immunological IMPROVE Infection Interaction knowledge less life history magnitude modeling natural infection Nonpharmaceutical interventions outcome pandemic Protective protective immunity provoke provoking risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Science severe cases sustained trajectory translation vaccination Vaccine Vaccines Variation variety [DOI] 10.1126/science.abd7343 PMC 바로가기 [Article Type] Research Article