Immunomodulatory Role of the Antimicrobial LL-37 Peptide in Autoimmune Diseases and Viral InfectionsReview Published on 2020-09-102022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] AMP AMPs antimicrobial antimicrobial peptide Antiviral approach autoantigen autocrine cascade Cathelicidin cytokine production dendritic cell disease disease pathogenesis disorders dissemination epidermal epithelial cells Express expressed expression Factors immune cells immunomodulatory activity immunomodulatory function increase induce Infection Inflammation initiate Innate immunity interferon limit LL-37 lupus erythematosus macrophages Monocytes Neutrophils paracrine produced progression of disease psoriasis role targeting trauma viral infections virus virus replication [DOI] 10.3390/vaccines8030517 PMC 바로가기 [Article Type] Review
Cytokine release syndrome: inhibition of pro-inflammatory cytokines as a solution for reducing COVID-19 mortality사이토카인 방출 증후군: COVID-19 사망률을 줄이기 위한 솔루션으로 전염증성 사이토카인 억제Review Published on 2020-09-012022-09-12 Journal: European cytokine network [Category] SARS, 진단, [키워드] acute respiratory distress affected anti-IL-6 antibody cascade cause Corona Corona virus COVID-19 COVID-19 mortality critically ill patients CRS cytokine level cytokine release Cytokine release syndrome death disease elevated end organ explained IL-1 IL-6 mechanism of action occur pandemic Patient Potential pro-inflammatory cytokine pro-inflammatory cytokines proportion reached reduce mortality rate reducing Severe case Severe patient syndrome the disease Therapeutic approach TNF-alpha Treatment [DOI] 10.1684/ecn.2020.0451 PMC 바로가기 [Article Type] Review
Vascular underpinning of COVID-191001 Published on 2020-08-272022-10-29 Journal: Open Biology [Category] COVID-19, MERS, [키워드] acute respiratory distress Alternative pathway cardiovascular cascade cells cellular COVID-19 COVID-19 pathogenesis COVID-19 virus Critically ill patient cytokine release develop distribution dysfunction dysregulated endothelial Endothelial cell Endothelial dysfunction Express facilitate Factor heterogeneity Host host cell surface Infection Inflammation information management guideline Mortality Organoid organs outcome pathogenic Patient pro-inflammatory cytokines prothrombotic condition reflect Replication Research SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 entry factors severe COVID-19 Single-cell RNA sequencing Stress syndrome thrombosis tissue triggering understanding undetectable Vascular vascular bed Vascular Biology vascular dysfunction vessel viral-induced virus while [DOI] 10.1098/rsob.200208 PMC 바로가기 [Article Type] 1001
Anticoagulant treatment in COVID-19: a narrative reviewArticle Published on 2020-08-182022-10-30 Journal: Journal of Thrombosis and Thrombolysis [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Algorithm anticoagulation cascade caused complement coronavirus COVID COVID 19 COVID 19 patient COVID-19 Cytokine storm develop disease disease severity Evidence Hyperactivation management mechanism multiple organs observé pandemic Pathogenesis Prognosis prothrombotic state risk SARS-CoV-2 therapy thrombosis Treatment treatment strategy virus-induced endothelial dysfunction [DOI] 10.1007/s11239-020-02242-0 PMC 바로가기 [Article Type] Article
Novel Use of Vitamin B2 as a Fluorescent Tracer in Aerosol and Droplet Contamination Models in OtolaryngologyOriginal Articles Published on 2020-08-142022-10-27 Journal: The Annals of Otology, Rhinology, and Laryngology [Category] Coronavirus, MERS, SARS, [키워드] aerodynamics aerosol average Cadaveric cascade coated with collected Contamination COVID-19 develop droplet droplets endonasal Fluorescein fluorescent healthcare impactor include investigated Measures Model mucosa mucosal nasal nasopharyngeal nasopharynx nebulized novel objective otolaryngology Particle reliability risk Safe safety profile subjects tracer utility UV light Vitamin vitamin B2 was used [DOI] 10.1177/0003489420949588 PMC 바로가기 [Article Type] Original Articles
Droplet and Aerosol Generation With Endonasal Surgery: Methods to Mitigate Risk During the COVID-19 Pandemic비말 수술을 통한 비말 및 에어로졸 생성: COVID-19 팬데믹 기간 동안 위험을 완화하는 방법Special Section on COVID-19 Published on 2020-08-112022-08-31 Journal: Otolaryngology--Head and Neck Surgery [Category] MERS, 진단, 치료제, [키워드] aerosol Aerosols burr Cadaveric cascade Complete Contamination COVID-19 drilling droplet Elimination endonasal evaluated flexible fluorescent followed by Generation identify Laboratory location Measures Mitigation nare nares nasal Nasal cavity nasopharynx nebulizer nose objective physician positioned prevention produced reduction Result risk risk reduction Safety setting Simulation skull base specimen suction surgical TARP was measured was used [DOI] 10.1177/0194599820949802 PMC 바로가기 [Article Type] Special Section on COVID-19
A new perspective for mitigation of SARS-CoV-2 infection: priming the innate immune system for viral attack1001 Published on 2020-07-292022-10-29 Journal: Open Biology [Category] COVID-19, [키워드] Activation Adults Anti-viral applied Asymptomatic carried cascade Clinical outcome clinical trial Complication Course COVID-19 death disease elevated elicit epidemiological evade Evidence example expected faster Hospitalization Hypothesis immune dysregulation immune factor immune response include individual individual level individuals infect Infection innate immune response innate immune system less Mild symptom mitigate occur Perspective pre-activation priming Probability reducing risk robust SARS-CoV-2 SARS-COV-2 infection severity Spread supported the epidemic Therapeutic approach trained immunity trajectory Vaccine Vaccines virus [DOI] 10.1098/rsob.200138 PMC 바로가기 [Article Type] 1001
Age-induced NLRP3 Inflammasome Over-activation Increases Lethality of SARS-CoV-2 Pneumonia in Elderly PatientsOpinion Published on 2020-07-232022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] activated macrophage advanced age age Analysis ASC cascade caspase-1 COVID-19 death displaying domain elderly Elderly patient expression level fibrosis IL-1 β IL-18 increase Increased increases in independent risk factor individual individuals Infection Inflammasome inflammasome activation interleukin lethality leucine lung Lung inflammation mice mitochondrial mRNA expression NLRP3 NLRP3 inflammasome Pneumonia predisposition Prognostic factor Protein provoking recent SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Specy Strategy subsequent [DOI] 10.14336/AD.2020.0601 PMC 바로가기 [Article Type] Opinion
Minireview Exploring the Biological Cycle of Vitamin B3 and Its Influence on Oxidative Stress: Further Molecular and Clinical AspectsReview Published on 2020-07-222022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] activate addition aspect Bioavailability Biological cascade clinical commensal bacteria complex Compound cycle deficiency demonstrated DNA Enzymes explain function gastrointestinal microflora Gut healthy homeostasis Host human behavior in vitro indicated infections influence mechanism of action metabolites niacin nicotinamide adenine dinucleotide Novel coronavirus Oocyte oocyte quality outcomes oxidative stress parameters proinflammatory reactive oxygen specy recent Research ROS SARS-CoV-2 SARS-CoV-2-infected patient subsequent Vitamin vitamin B3 [DOI] 10.3390/molecules25153323 PMC 바로가기 [Article Type] Review
COVID-19 and the Kidneys: An UpdateMedicine Published on 2020-07-212022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Activation Acute kidney injury age AKI alveolar damage cascade Chronic kidney disease clinical trials Coagulation common cold complement COVID-19 creatinine demonstrated dialysis Direct disease disease pathogenesis displaying Effect Efficacy fatality General population health emergency Hematuria Hemodialysis impairment individual Inflammation Injury kidney kidney damage kidney transplant recipients majority Mild multiorgan failure New coronavirus Patient progressive respiratory failure resulting specific treatment Symptom tested thought Transplant virus with COVID-19 [DOI] 10.3389/fmed.2020.00423 PMC 바로가기 [Article Type] Medicine