Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis유전자 공동 발현 네트워크 분석에 기초한 코로나 바이러스 (SARS-COV-2)에 대한 약물 재생Article Published on 2021-11-082022-08-31 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 신약개발, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome analyses Analysis applied approach Asia candidate drug candidate drugs cisplatin co-expression Computational models contagious coronavirus Cyclophosphamide database disease drug Drug repurposing Drug screening drugs drugs targeting effective drug effective drugs FIVE FLUOROURACIL gene co-expression network Gene ontology Genes Genome Interaction list METHYLDOPA Microarrays miRNA miRNAs reconstructed respiratory Respiratory illness retrieved SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 disease Severe acute respiratory syndrome Sirolimus Systems biology target gene the SARS-CoV-2 transcription factor transcription factors treat Treatment Viral viral respiratory virus [DOI] 10.1038/s41598-021-01410-3 PMC 바로가기 [Article Type] Article
SARS-CoV-2 variants and effectiveness of vaccines: a review of current evidenceSARS-CoV-2 변이체 및 백신의 효과: 현재 증거 검토Review Published on 2021-11-042022-09-11 Journal: Epidemiology and Infection [Category] MERS, SARS, 변종, 진단, [키워드] Adenovirus administration Alpha B.1.617.2 binding circulating variant contagious Delta dominant Effectiveness Epsilon Evidence human ACE2 receptor Immune escape increase morbidity Mortality mRNA Mutagenesis natural infection Neutralizing activity pandemic Protein provoke public health Recombinant protein Reinfection SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 virus severe acute respiratory syndrome coronavirus 2 significantly spike mutations Transmissibility vaccination Vaccine Vaccines variant variants variants of concern variants of interest variants of SARS-CoV-2 VoC VOCs [DOI] 10.1017/S0950268821002430 PMC 바로가기 [Article Type] Review
Understanding mutation hotspots for the SARS-CoV-2 spike protein using Shannon Entropy and K-means clusteringShannon Entropy 및 K-means 클러스터링을 사용한 SARS-CoV-2 스파이크 단백질의 돌연변이 핫스팟 이해Article Published on 2021-11-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, [키워드] Analysis carried Characteristics Cluster Clustering Community complex contagious determine Entropy helping hotspot identify in some indels K-means clustering laboratory investigation mutant mutants Mutation mutational hotspot mutations nine predicted Region regions required Research SARS-CoV-2 SARS-CoV-2 virus sequence Shannon entropy similarities similarity situation Spike protein statistical Substitution substitutions survival susceptible the SARS-CoV-2 the spike protein Therapeutics time-consuming understanding variant variants variants of concern variants of interest virus zone [DOI] 10.1016/j.compbiomed.2021.104915 PMC 바로가기 [Article Type] Article
Modeling the impact of SARS-CoV-2 variants and vaccines on the spread of COVID-19Research article Published on 2021-11-012022-10-05 Journal: Communications in Nonlinear Science and Numerical Simulation [Category] 변종, [키워드] 501.V2 African Characteristics contagious coronavirus country COVID-19 vaccines develop disease Effect effective effective reproduction number evaluate Evolution example expected Follow-up Government greater Infection infections Italy knowledge Laboratory less main mechanism mathematical measure modeling mortality rates Mutation observé outcomes pandemic question reduce reported Reproduction number Research SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants significantly South Spread spread of COVID-19 the disease the vaccine United Kingdom vaccination vaccination rate Vaccine Vaccines variant virus VOC 202012/01 would increase θθ-SIR Type model [DOI] 10.1016/j.cnsns.2021.105937 [Article Type] Research article
Harris Hawks optimisation with Simulated Annealing as a deep feature selection method for screening of COVID-19 CT-scansResearch article Published on 2021-11-012022-10-05 Journal: Applied Soft Computing [Category] 치료기술, [키워드] Accuracy acute respiratory syndrome Algorithm Algorithms approach caused Chaotic initialisation CNN composed contagious Convolutional neural network coronavirus Coronavirus disease 2019 COVID-19 COVID-19 detection CT scan CT scan image CT-scan CT-scans dataset death decrease detect disease evaluated feature Features Harris Hawks optimisation Hawk help Inclusion increase infected individuals network Neural patients radiological SARS-CoV-2 selected Severe case Simulated Annealing utilised variant variants [DOI] 10.1016/j.asoc.2021.107698 [Article Type] Research article
Effects of Bacille Calmette Guerin (BCG) vaccination during COVID-19 infectionResearch article Published on 2021-11-012022-10-05 Journal: Computers in biology and medicine [Category] SARS, 바이오마커, 변종, [키워드] activities acute respiratory syndrome ADORA3 analysed Analysis Bacille calmette guerin (BCG) BCG BCG vaccination caused CCL4 CCR2 CD33 Comorbidity condition contagious coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID‐19 Critical CXCL1 CXCL8 cytokine DEGs differentially expressed gene Differentially expressed genes driving drug candidate Drug molecules Effect elements enrichment analysis expression expression pattern finding functional Functional enrichment analysis Gene ontology Genes Genetic IFNg IL-17 Infection Interaction investigated ITGB2 miRNA molecular mononuclear cell more difficult Mortality network analysis Novel coronavirus pandemic pathway Pathways PBMC Peripheral blood PPI PTGS2 Regulatory Research SARS-CoV-2 SARS-COV-2 infection severity significantly Spread TFS therapeutic TLR5 transcriptomic vaccination Vaccine virus spread [DOI] 10.1016/j.compbiomed.2021.104891 [Article Type] Research article
Mucus targeting as a plausible approach to improve lung function in COVID-19 patientsResearch article Published on 2021-11-012022-10-05 Journal: Medical Hypotheses [Category] SARS, 유전자 메커니즘, [키워드] airway Airway mucus approach Asthma Autopsy Care carried clearance clinical trials contagious COPD COVID-19 COVID-19 patient COVID-19 patients COVID-19 symptoms Cytokine storm develop disorder distress evaluated globe Health Health care system help highlight hypoxia IMPROVE Infection inflammatory phase inhibit Lung function mucins Mucus Mucus Hypersecretion Obstructive organ overexpression oxygen supply Pandemics Patient Research respiratory distress SARS CoV 2 SARS-CoV-2 secretion severe pneumonia similarity subjects subsequent Symptom the disease therapy ventilator worsening [DOI] 10.1016/j.mehy.2021.110680 [Article Type] Research article
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication지방산 합성의 약리학적 억제는 SARS-CoV-2 복제를 차단합니다Article Published on 2021-11-012022-09-11 Journal: Nature metabolism [Category] MERS, SARS, 변종, 신약개발, 진단, 치료제, [키워드] ACACA acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway airways block cellular clinical clinical trials contagious coronavirus COVID-19 death Delta drug Drug administration drug candidate drug candidates Efficacy evaluate FASN fatty Fatty acid food Genes hACE2 humans identify in vitro inflammatory disease inhibit inhibiting inhibitor injection Injections Intervention K18-hACE2 K18-hACE2 transgenic mice leads lung Lung pathology Lungs metabolic genes mouse model Multi-organ damage offer orlistat pathway pharmacological promote reduced replication of SARS-CoV-2 required respiratory RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 variants SARS-CoV-2 viral SARS-CoV-2 viral infection screened Screening severe acute respiratory syndrome Coronavirus severe COVID-19 survival target transgenic mice Treatment treatment of COVID-19 Trial variants Viral [DOI] 10.1038/s42255-021-00479-4 PMC 바로가기 [Article Type] Article
Potential recurrence of COVID-19 in a healthcare professional: SARS-CoV-2 genome sequencing confirms contagiousness after re-positivityCase report Published on 2021-11-012022-10-05 Journal: International Journal of Infectious Diseases [Category] SARS, 유전자 메커니즘, [키워드] absence contagious contagiousness COVID-19 discharge Genome sequencing Guidance healthcare Healthcare professional Infectivity Isolation Patient Potential raising Re-positivity replication-competent virus reported SARS-CoV-2 SARS-CoV-2 genome sequencing SARS-CoV-2 test secondary case secondary cases suggested Viral genome sequencing [DOI] 10.1016/j.ijid.2021.09.035 [Article Type] Case report
High class filtering facepiece (FFP) are fundamental and effective in protection of emergency health care workers: an observational cohort study in a German community고급 필터링 안면부(FFP)는 응급 의료 종사자를 보호하는 데 기본적이고 효과적입니다. 독일 커뮤니티의 관찰 코호트 연구Observational Study Published on 2021-10-302022-09-10 Journal: Scandinavian Journal of Trauma, Resuscitation and [Category] MERS, SARS, 변종, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition airway Analysis analyzed aspect belief Care Chain Reaction Cohort Community condition Contact contagious Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 infections disease effective Effectiveness Efficiency emergency medical service Emergency medical services exposure to FFP2 Filtering facepiece flu Health Hospital staff immunoassay incidence involved lowest Masks medical service medical staff N95 NPC Observational cohort study pandemic coronavirus participant Patient Patient care PCR Personal protection equipment physical polymerase chain polymerase chain reaction positive positive PCR positive SARS-CoV-2 result Prevent quantity respiratory Result SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 positive patient SARS-CoV-2 positive patients self-assessment Seroprevalence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly higher Symptom three group three groups Vaccines Viral viral variant virus was performed [DOI] 10.1186/s13049-021-00969-0 PMC 바로가기 [Article Type] Observational Study