Strategies for drug repurposing against coronavirus targetsCOVID-19 therapy edited by Isabella Zanella & Simon Pitchford Published on 2021-12-042022-10-04 Journal: Current Research in Pharmacology and Drug Discovery [Category] 신약개발, [키워드] agency approved drug ARDS attrition Compound coronavirus coronavirus target de novo drug Drug discovery Drug repurposing Epidemic hospital human coronaviruses Impact in silico screening in viral involved MERS-CoV pandemic Patient Proteases public health Regulatory repurposing safety profile SARS-CoV SARS-CoV-2 significantly Strategy target Treatment viral replication viral-induced virus widespread [DOI] 10.1016/j.crphar.2021.100072 PMC 바로가기 [Article Type] COVID-19 therapy edited by Isabella Zanella & Simon Pitchford
Drug Repurposing for Influenza Virus Polymerase Acidic (PA) Endonuclease InhibitorArticle Published on 2021-12-022023-06-08 Journal: Molecules [Category] 신종인플루엔자, [키워드] Drug repurposing lifitegrast Virtual screening [DOI] 10.3390/molecules26237326 PMC 바로가기 [Article Type] Article
Discovery of quinazoline derivatives as a novel class of potent and in vivo efficacious LSD1 inhibitors by drug repurposingResearch article Published on 2021-12-012022-10-05 Journal: European journal of medicinal chemistry [Category] 신약개발, [키워드] addition Antitumor Apoptosis Cancer therapy cancers candidate cells cellular demethylase derivative dosage Drug repurposing effort EGFR enzyme epigenetic modulator Erlotinib FDA-approved drug histone IC50 implicated induce inhibit inhibitor inhibitory activity LSD1 lung cancer Migration Pathogenesis provide Quinazoline reduction in screened significantly specificity suppress suppressed therapeutic target Treatment [DOI] 10.1016/j.ejmech.2021.113778 [Article Type] Research article
Drug repurposing in COVID-19: A review with past, present and futureResearch article Published on 2021-12-012022-10-05 Journal: Metabolism Open [Category] 신약개발, 임상, 치료제, [키워드] ACE2 Applying approach approaches approved cause clinical conditions clinical trials conducted coronavirus disease coronavirus SARS-CoV-2 COVID-19 COVID-19 disease COVID19 drug Drug repurposing effective Effectiveness ENCODE Favipiravir FDA food Genome global public health host cell surface identify in vitro infection process initiate Interaction molecular docking problems protease inhibitors Protein Protein structure‐based drug design Remdesivir reuse ribavirin Ritonavir RNA virus SARS CoV2 SARS-CoV2 shown single-stranded positive-sense spike structural proteins therapeutic agent Tocilizumab treat [DOI] 10.1016/j.metop.2021.100121 [Article Type] Research article
Repurposing old molecules for new indications: Defining pillars of success from lessons in the pastReview article Published on 2021-12-012022-10-05 Journal: European journal of pharmacology [Category] 신약개발, [키워드] addition adopted approach attrition biological assay Biomarker Characteristics clinical evaluation clinical trial Compound recycling de novo defined develop Diseases drug Drug repurposing Drug rescue Effects Efficacy element Evidence Extended profiling Formulation identify include indication indications key factor knowledge lack Market exclusivity methodology observation off-label overcome pharmacological Regulatory Repositioning model repurposing resources robust therapeutic utility timelines translational [DOI] 10.1016/j.ejphar.2021.174569 [Article Type] Review article
Proteomics advances towards developing SARS-CoV-2 therapeutics using in silico drug repurposing approachesProteomics는 in silico 약물 용도 변경 접근법을 사용하여 SARS-CoV-2 치료제 개발을 위해 발전합니다.Review Published on 2021-12-012022-09-11 Journal: Drug Discov Today Technol [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] approach Biomarker contributed COVID-19 COVID-19 pandemic Diagnosis drug Drug administration drug candidate Drug repurposing effective FDA food host proteins identify in silico in-silico interactomics molecular docking motion Prognosis proteomics Remdesivir Repurposed drugs robust SARS-CoV-2 SARS-CoV-2 protein Scientific community significantly Standing Streamline target targets the disease therapeutic therapeutic target therapeutic targets US Food and Drug Administration [DOI] 10.1016/j.ddtec.2021.06.004 PMC 바로가기 [Article Type] Review
Recent advances in drug repurposing using machine learningReview article Published on 2021-12-012022-10-05 Journal: Current Opinion in Chemical Biology [Category] 신약개발, [키워드] Alzheimer’s disease approved drugs Cancer computational approach COVID-19 Drug discovery Drug repurposing highlight kinase inhibitors machine learning recent [DOI] 10.1016/j.cbpa.2021.06.001 [Article Type] Review article
Applications of artificial intelligence in COVID-19 pandemic: A comprehensive reviewReview article Published on 2021-12-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 신약개발, 진단, 치료기술, [키워드] Analysis application artificial intelligence caused combating COVID-19 COVID-19 outbreak COVID-19 pandemic Critical database deep learning Diagnosis diagnostics dominant Drug repurposing global public health Google Scholar Government Health healthcare help Human machine learning mitigate novel coronavirus disease organizations outcomes outperform recent recommendation Research researcher researchers SARS-CoV-2 shown was selected [DOI] 10.1016/j.eswa.2021.115695 [Article Type] Review article
Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence그래프 신경망을 사용하여 COVID-19에 대한 약물 용도 및 여러 증거 조화Article Published on 2021-11-302022-08-31 Journal: Scientific Reports [Category] 신약개발, 임상, 치료법, 치료제, [키워드] 2019 novel coronavirus 2019 novel coronavirus disease acetaminophen albuterol approach Aspirin atorvastatin Azithromycin candidate drug candidate drugs clinical trial collected conducted coronavirus disease COVID-19 COVID-19 knowledge COVID-19 patient COVID-19 treatment demonstrated disease drug drug combination drug combinations Drug development Drug repurposing drugs Efficacy Evidence facilitate FDA approval Genetic highlight host genes in vitro integration Interaction interactions Knowledge graph Novel coronavirus novel coronavirus disease outbreak pandemic Pathways Phenotypes profiles Research Treatment Virtual screening virus was used [DOI] 10.1038/s41598-021-02353-5 PMC 바로가기 [Article Type] Article
Drug Repurposing to Identify Nilotinib as a Potential SARS-CoV-2 Main Protease Inhibitor: Insights from a Computational and In Vitro Study잠재적인 SARS-CoV-2 주요 프로테아제 억제제로 닐로티닙을 식별하기 위한 약물 용도 변경: 전산 및 시험관 연구에서 얻은 통찰력Article Published on 2021-11-222022-09-11 Journal: Journal of Chemical Information and Modeling [Category] SARS, 신약개발, 치료제, [키워드] 6LU7 active site Analysis antiviral activity antiviral therapeutics Bank bemcentinib binding affinity binding energy Cell culture computer-aided drug design COVID-19 database drug Drug Bank drug candidate drug design Drug repurposing drugs experiment Glu166 high accuracy His41 independent indication inhibitor insight Interaction M pro MD simulation MD simulations medication molecular molecular docking molecular dynamics Molecular dynamics simulation Nilotinib pandemic Partial Potential predicted repurposing researcher SARS-CoV-2 sequence significantly strength subset suggested the binding affinity the SARS-CoV-2 Viral pneumonia Virtual screening was performed were measured [DOI] 10.1021/acs.jcim.1c00524 PMC 바로가기 [Article Type] Article