The Impact of COVID-19 on Patient, Family Member, and Stakeholder Research Engagement: Insights from the PREPARE NOW StudyArticle Published on 2022-04-012022-10-05 Journal: Journal of General Internal Medicine [Category] 임상, [키워드] Analysis approach Authenticity Care changes in conducted COVID-19 Data analysis eight emotional engage family Health help high risk Impact impacted include insight involved kidney Kidney disease less majority manuscript member outcome participant participated Patient patient engagement patient-centered patient-centered outcomes research. patients PCORI question reported Research respondent suggestion [DOI] 10.1007/s11606-021-07077-w PMC 바로가기 [Article Type] Article
Cardiopulmonary Rehabilitation in Long-COVID-19 Patients with Persistent Breathlessness and Fatigue: The COVID-Rehab StudyRandomized Controlled Trial Published on 2022-03-312022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] 1:1 affected blood draw Brain Cardiopulmonary cardiorespiratory clinical trial Coagulation Cognition COVID-19 COVID-19 infection Effectiveness eight evaluated exercise function functional include individual individuals Inflammatory intervention arm Long COVID maintain Neurovascular Patient patients Perceived stress persistent physical physical activity Quality of life Questionnaires randomised recruit rehabilitation respiratory rehabilitation Secondary objective sleep quality spirometry [DOI] 10.3390/ijerph19074133 PMC 바로가기 [Article Type] Randomized Controlled Trial
Enhancing Physical Activity and Psychological Well-Being in College Students during COVID-19 through WeActive and WeMindful InterventionsRandomized Controlled Trial Published on 2022-03-312022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] activity aerobic All participant assigned college COVID-19 Effect effective eight Enhancing Follow-up group intensity Intervention moderate participant physical physical activity Qualtrics Randomly Resilience resilience score Resistance training scale significant interaction significantly increased student university students web-based intervention. [DOI] 10.3390/ijerph19074144 PMC 바로가기 [Article Type] Randomized Controlled Trial
Statistical modeling of SARS-CoV-2 substitution processes: predicting the next variantSARS-CoV-2 대체 과정의 통계적 모델링: 다음 변종 예측Article Published on 2022-03-292022-09-11 Journal: Communications Biology [Category] SARS, 변종, [키워드] Amino acid amino acid changes amino acid substitution build candidate candidate models Candidates COVID-19 creating eight Factor knowledge Mutation Non-synonymous occur predict random SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 sequences sequence statistical model the SARS-CoV-2 Vaccine design validation process variant variants virus [DOI] 10.1038/s42003-022-03198-y PMC 바로가기 [Article Type] Article
Behavioural Activation for Social IsoLation (BASIL+) trial (Behavioural activation to mitigate depression and loneliness among older people with long-term conditions): Protocol for a fully-powered pragmatic randomised controlled trialBASIL+(사회적 고립을 위한 행동 활성화) 시험(장기 조건을 가진 노인의 우울증과 외로움을 완화하기 위한 행동 활성화): 완전한 실용주의 무작위 통제 시험을 위한 프로토콜Article Published on 2022-03-242022-09-11 Journal: PLoS ONE [Category] 임상, [키워드] 1:1 acceptability Activation Adults Anxiety BASIL build Care clinical clinically ClinicalTrials collected conducted consequence Control Controlled trial COVID-19 COVID-19 pandemic Depression depressive symptom Depressive symptoms eight eligible England evaluate evaluated for inclusion Health health problem Health Service include increased risk information Intervention Isolation life loneliness Long-term condition long-term conditions Mental mental health mitigate Older outcome parallel-group participant Participants physical physically Pragmatic Primary outcome Psychological intervention Quality of life questionnaire randomisation randomised controlled trial receive recruited Registered Research scored secondary Secondary outcomes self-help social isolation stratified Support supported Trial Two-arm usual care worker [DOI] 10.1371/journal.pone.0263856 PMC 바로가기 [Article Type] Article
Efficacy and Safety of BCG Revaccination With M. bovis BCG Moscow to Prevent COVID-19 Infection in Health Care Workers: A Randomized Phase II Clinical TrialClinical Trial Published on 2022-03-222022-10-05 Journal: Frontiers in Immunology [Category] 임상, [키워드] Activation approved Bacillus BCG carried children clinical clinical trial COVID-19 COVID-19 pandemic cross cross protection Efficacy Efficacy and safety eight HCW HCWs Health care worker IgM and IgG immune response IMPROVE incidence of COVID-19 individual induce innate response Mycobacterium bovis NK cell NK cells phase PROTECT protocol randomized-controlled Randomly ranged reducing Registered respiratory infection revaccination Safe Safety statistical significance Symptoms symptoms of COVID-19 the WHO Tuberculosis Vaccine viral infections [DOI] 10.3389/fimmu.2022.841868 PMC 바로가기 [Article Type] Clinical Trial
In vitro evaluation of therapeutic antibodies against a SARS-CoV-2 Omicron B.1.1.529 isolateSARS-CoV-2 Omicron B.1.1.529 분리주에 대한 치료 항체의 시험관 내 평가Article Published on 2022-03-182022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] analyzed antibodies antibody B.1 B.1.1.529 BavPat1 cilgavimab Clinical efficacy combination therapies combination therapy D614G dose doses Efficacy eight evaluated loss of activity modify monoclonal antibodies monoclonal antibody neutralize Neutralizing Neutralizing activity omicron Omicron variant reduction reduction in resulting SARS-CoV-2 Sotrovimab spike glycoprotein Spread Substitution the antibody therapeutic therapeutic antibodies Tixagevimab Vaccine variant variant of SARS-CoV-2 [DOI] 10.1038/s41598-022-08559-5 PMC 바로가기 [Article Type] Article
Impact of residual risk messaging to reduce false reassurance following test-negative results from asymptomatic coronavirus (SARS-CoV-2) testing: an online experimental study of a hypothetical testRandomized Controlled Trial Published on 2022-03-162022-10-04 Journal: BMJ Open [Category] SARS, 임상, [키워드] 95% CI addition Asymptomatic coronavirus COVID-19 eight experiment hypothetical Impact individual information lateral flow likelihood negative test NHS no risk participant Prolific proportion protective behaviour Protective behaviours public health Randomly Ratio receive recruited reduce residual residual risk risk SARS-CoV-2 Test tested trace understanding was done [DOI] 10.1136/bmjopen-2021-056533 PMC 바로가기 [Article Type] Randomized Controlled Trial
Four Weeks Treatment with Glecaprevir/Pibrentasvir + Ribavirin-A Randomized Controlled Clinical Trial글레카프레비르/피브렌타스비르 + 리바비린-A 무작위 대조 임상 시험으로 4주간 치료Randomized Controlled Trial Published on 2022-03-162022-09-11 Journal: Viruses [Category] 임상, 치료제, [키워드] analyzed baseline chronic hepatitis chronic hepatitis C clinical Controlled Controlled trial Course COVID-19 pandemic cure DAA eight Enhancing fibrosis Genotype glecaprevir HCV Health Organization Hepatitis hepatitis C intention to treat Liver fibrosis multicenter naïve open label Patient patients treated pibrentasvir predictor predictors Randomized Randomized controlled trial reducing ribavirin stratified sustained Treatment Trial Viral load virological response Week World Health Organization [DOI] 10.3390/v14030614 PMC 바로가기 [Article Type] Randomized Controlled Trial
Circulating Levels of PD-L1, TIM-3 and MMP-7 Are Promising Biomarkers to Differentiate COVID-19 Patients That Require Invasive Mechanical VentilationPD-L1, TIM-3 및 MMP-7의 순환 수준은 침습적 기계 환기가 필요한 COVID-19 환자를 구별하는 유망한 바이오마커입니다Article Published on 2022-03-142022-09-11 Journal: Biomolecules [Category] Coronavirus, MERS, SARS, 바이오마커, [키워드] 105 patient 105 patients acute disease Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Biomarker Biomarkers caused Clinical data Coronavirus-2 correlated COVID-19 COVID-19 patient diagnosed with COVID-19 disease disease severity eight ELISA evaluate exhibited followed by highest Hospital stay IMV Infectious disease Invasive mechanical ventilation Level lung lesion lung lesions marker Mechanical molecules NIMV PaO Patient patients PD-L1 persistence Potential biomarker potential biomarkers quantified respiratory Respiratory failure ROC analysis RT-PCR SARS-CoV-2 sensitivity Serum level serum levels Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significant decrease specificity T-cell T-cells two group two groups was increased [DOI] 10.3390/biom12030445 PMC 바로가기 [Article Type] Article