hACE2 – Page 20 – Communicable Diseases Research

SARS-CoV-2 infection in the mouse olfactory system

Article

Published on 2021-07-062022-10-04
Journal: Cell Discovery [Category] 진단,

ACE2-lentiviral transduction enables mouse SARS-CoV-2 infection and mapping of receptor interactions

Research Article

Published on 2021-07-022022-10-29
Journal: PLoS Pathogens [Category] COVID-19, SARS,

[키워드] ACE2 analyses Analysis can be used Cell cell line COVID-19 COVID-19 patients COVID-19 research driving explain Express H353K hACE2 histological human ACE2 identify IFNAR in vitro in vivo infect infect cells Infection inflammatory disease Inflammatory response Inflammatory responses Interaction interferon response interferon signaling involved key amino acid lung lung epithelium mACE2 mice Mutagenesis no significant effect receptor Replication required rescued SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 research substitutions Support tissue repair transcriptomic profile transduction type I utility Vaccine Vaccines virus virus replication was used were used
[DOI] 10.1371/journal.ppat.1009723 PMC 바로가기 [Article Type] Research Article

Fusion Protein of Rotavirus VP6 and SARS-CoV-2 Receptor Binding Domain Induces T Cell Responses

Communication

Published on 2021-07-022022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] antibodies antigen-presenting cells antigenic B cell B cell epitope BALB/c mice caused Cell cell-mediated immune response conditions conformational COVID-19 cross-reactive delivery platform displaying domain fusion fusion protein hACE2 human Angiotensin-converting enzyme humoral immune response Immunity immunize in vitro investigated long-lasting mRNA N-terminus pandemic platform populations produced RBD receptor respiratory response rotavirus S-specific antibody SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 spike protein T cell T cell epitope T cells Vaccine vaccine candidate Vaccines Viral vector VP6 was used
[DOI] 10.3390/vaccines9070733 PMC 바로가기 [Article Type] Communication

CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

CVnCoV 및 CV2CoV는 조상 B BavPat1 및 신흥 B.1.351 SARS-CoV-2로부터 인간 ACE2 형질전환 마우스를 보호합니다

Article

Published on 2021-06-302022-09-10
Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료기술,

[키워드] antibody Antibody titers B.1.351 B.1.351 variant BavPat1 Brain caused clinical development Complete controls CVnCoV detectable develop disease Efficacy elevated formalin groups hACE2 host immunity human ACE2 immunized K18-hACE2 lung mice Mortality mRNA mRNA vaccine mRNA vaccines mutant Mutation neutralization titer neutralization titers Neutralizing antibody titer PROTECT raise reduced SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant SARS-CoV-2 variants significantly Spike protein swabs the spike protein transgenic mice Transgenic mouse Vaccine vaccine efficacy Vaccines variants variants of concern Viral viral strain VoC was tested were used
[DOI] 10.1038/s41467-021-24339-7 PMC 바로가기 [Article Type] Article

AI-based spectroscopic monitoring of real-time interactions between SARS-CoV-2 and human ACE2

530

Published on 2021-06-292022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS,

Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry

Article

Published on 2021-06-262022-10-28
Journal: Viruses [Category] COVID-19, SARS,

[키워드] activities acute infection acute respiratory syndrome anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity antimicrobial peptides Antiviral antiviral activity binding blocked blocking Cell contribute COVID-19 disease Critical defensin Defensins Effect epithelial cells exhibited expressing Factor form hACE2 had no HNP1 Human Immunity Infection inhibited Innate innate immune intestinal investigated linear Lung epithelial cells MERS Middle East neutrophil outcomes Paneth cells peptide peptides Post-infection precursor protective effect provided Pseudotyped virus replication-competent SARS-CoV-2 reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike proteins SARS-CoV-2 variants severity spike receptor-binding domain syndrome the disease viral entry viral infection virion virus virus titer β-defensin
[DOI] 10.3390/v13071246 PMC 바로가기 [Article Type] Article

Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species

인간과 다른 종의 ACE2에 대한 박쥐 코로나바이러스 RaTG13 바이러스의 결합 및 분자적 기초

Article

Published on 2021-06-242022-09-11
Journal: Cell [Category] MERS, SARS, 변종, 진단,

[키워드] ACE2 ACE2 orthologs acute respiratory syndrome acute respiratory syndrome coronavirus animal reservoirs binding carried complex continuous surveillance coronavirus COVID-19 CoVs cross-neutralize cross-reactive antibody evaluated global pandemic hACE2 horseshoe bat Host host range Human human ACE2 induce intermediate horseshoe bat intermediate horseshoe bat. mAb mechanism molecular basis monoclonal antibody phylogenetically Prevent pseudovirus RaTG13 RBD Receptor binding Receptor binding domain reservoir residue residues respiratory SARS-CoV-2 SARS-CoV-2 RBD severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Surveillance the SARS-CoV-2 variants variants of concern virus VOCs
[DOI] 10.1016/j.cell.2021.05.031 PMC 바로가기 [Article Type] Article

In silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for virus origin

SARS-COV-2 스파이크 단백질 -ACE2 결합 친화력의 SILICO 비교에서 종에 대한 바이러스 기원에 대한 영향

Article

Published on 2021-06-242022-09-10
Journal: Scientific Reports [Category] MERS, 유전자 메커니즘,

[키워드] ACE2 affinity analyses angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 approach binding binding affinity can be used caused Chemistry Computational biology and bioinformatics Computational chemistry correlation COVID-19 pandemic Diseases docking Drug discovery enzyme exhibited explain ferret generate hACE2 help helping highest highest binding affinity highlight human ACE2 humans hydrogen Hydrogen bond hydrogen bonds implication in silico Infection information mechanism molecular dynamics Molecular dynamics simulation much lower novel virus Novel viruses pangolin power predict predicted Protein question raised respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 spike sequence sequence homology sequence similarity shown Small molecules spike Spike protein structural biology structural homology susceptibility tested transfer Transmission vectors virus viruses
[DOI] 10.1038/s41598-021-92388-5 PMC 바로가기 [Article Type] Article

Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2

Research Article

Published on 2021-06-242022-10-29
Journal: PLoS Pathogens [Category] COVID-19, MERS, SARS,

[키워드] 293T cells Affect antibodies binding Cell clinical settings cloned co-transfection complement compounds convalescent sera correlated correlation COVID-19 demonstrated dimensions Efficacy Efficiency effort equipment Factor FDA global public health hACE2 high throughput screen identify immune protection in vitro Infection inhibitors of SARS-CoV-2 Interaction interfere Laboratory Live virus monoclonal antibodies Neutralization assay Other Plasmid Pseudotyped virus Rapid reagent Research Result sera stable cell line stable cell lines the SARS-CoV-2 the vaccine therapeutic time-consuming vaccination Vaccine virus titer was tested
[DOI] 10.1371/journal.ppat.1009683 PMC 바로가기 [Article Type] Research Article

Natural variants in SARS-CoV-2 Spike protein pinpoint structural and functional hotspots with implications for prophylaxis and therapeutic strategies

Article

Published on 2021-06-232022-10-29
Journal: Scientific Reports [Category] COVID-19,

[키워드] acute respiratory syndrome amino acid substitution bind comprehensive analysis conducted Consequences coronavirus Coronavirus 2019 COVID-19 COVID-19 pandemic effective vaccine functional Genetic greater hACE2 help hotspot Human human Angiotensin-converting enzyme implication infection rate information Molecular modelling Mutation natural Novel coronavirus occur outbreak pandemic Pneumonia Prophylaxis Protein Protein sequence analyses receptor reduced SARS-CoV-2 SARS-CoV-2 transmission sensitivity sequence severe disease Severe respiratory distress spike Spread Substitution the S protein the Spike therapeutic strategy unique variant variations virus Wuhan, China
[DOI] 10.1038/s41598-021-92641-x PMC 바로가기 [Article Type] Article