Development of Spike Receptor-Binding Domain Nanoparticles as a Vaccine Candidate against SARS-CoV-2 Infection in FerretsResearch Article Published on 2021-03-022022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 Antigen Body weight loss candidate clearance Clinical symptoms coronavirus CoV COVID-19 demonstrated development disease domain effective ferret ferritin Fever Helicobacter pylori Host host cell immunization induce Infectious virus Interaction intramuscular intranasal lung mammalian cell nanoparticle nasal washe neutralizing antibody organs pandemic produced protective immunity Protein purified RBD RBD-nanoparticle Receptor-binding domain SARS-CoV-2 SARS-COV-2 infection spike the RBD the spike protein Vaccine vaccine candidate Vaccines Viral RNA [DOI] 10.1128/mBio.00230-21 PMC 바로가기 [Article Type] Research Article
ACE-2-interacting Domain of SARS-CoV-2 (AIDS) Peptide Suppresses Inflammation to Reduce Fever and Protect Lungs and Heart in Mice: Implications for COVID-19 TherapySARS-CoV-2(AIDS) 펩티드의 ACE-2 상호작용 도메인은 염증을 억제하여 발열을 줄이고 마우스의 폐와 심장을 보호합니다: COVID-19 치료에 대한 시사점Article Published on 2021-03-012022-09-12 Journal: Journal of neuroimmune pharmacology : the official [Category] 진단, [키워드] ACE-2 ACE2 Activation activities activity acute respiratory syndrome AIDS angiotensin-converting enzyme 2 Arrhythmias association bind caused cells coronavirus COVID-19 COVID-19 therapy domain effective therapy expression Fever heart host cells human lung IL-6 impairment increase in infectious respiratory illness infiltration of neutrophil inhibit inhibited Interaction intranasal locomotor Lung inflammation Lungs mice mimicking mutated NF-κB peptide reduced SARS-CoV-2 SARS-CoV-2 spike selective spike Spike S1. symptoms of COVID-19 therapeutic Treatment virus strain wild type [DOI] 10.1007/s11481-020-09979-8 PMC 바로가기 [Article Type] Article
Hamster and ferret experimental infection with intranasal low dose of a single strain of SARS-CoV-2SARS-CoV-2의 단일 균주의 비강 내 저용량으로 햄스터 및 흰 족제비 실험 감염Article Published on 2021-03-012022-09-11 Journal: The Journal of General Virology [Category] MERS, SARS, 진단, 치료기술, [키워드] Antiviral strategies Brain can be used clinical disease COVID-19 drugs excretion experimental animal model experimental model experimental models ferret ferrets French hamster hamsters immune response immune responses in vivo individual Infection infection levels inoculation intranasal Kinetics low dose lung Lungs Medulla oblongata Mild oblongata olfactory olfactory bulb Pathogenesis pathogenicity pathology protective effect remained resolved RNA SARS-CoV-2 SARS-COV-2 infection serological response severe disease severity the disease the SARS-CoV-2 therapeutic strategy understanding undetectable Viral Viral RNA virus [DOI] 10.1099/jgv.0.001567 PMC 바로가기 [Article Type] Article
Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses최첨단: 마우스 SARS-CoV-2 에피토프, 감염 및 백신 유발 CD8 T 세포 반응 밝혀내Article Published on 2021-03-012022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] SARS, 변종, 치료법, [키워드] Adenovirus CD8 CD8 T cell COVID-19 COVID-19 vaccine cross-reactivity Culture Cutting dominant elicited epitope Heterologous HLA-A HLA-A*02 hospitalized patient hospitalized patients human ACE2 human disease Humoral immunity Immunity immunization intranasal magnitude memory mice mouse mucosa PBMC peptide recombinant adenovirus respiratory mucosa response responses robust SARS-CoV-2 SARS-CoV-2 nucleoprotein severity Spike protein systemically T cell T cell response T cell responses transgenic mice vaccination vaccine-elicited T cell vector viral spike protein Viral variants [DOI] 10.4049/jimmunol.2001400 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamstersSARS-CoV-2 감염은 보호 면역을 유도하고 시리아 햄스터의 전파를 제한합니다Research Article Published on 2021-02-112022-09-12 Journal: Life Science Alliance [Category] MERS, SARS, 진단, [키워드] accompanied caused close contact Critical death demonstrated develop effective vaccine Effective vaccines hamster hamsters help Immunity induce infections initial intranasal Laboratory limit Log reduction lung Lungs Median viral load morbidity MOST naïve nasal washe natural infection Neutralizing antibodies Prevent PROTECT protective immunity public health question recovered patient recovered patients Reinfection representing SARS-CoV-2 SARS-COV-2 infection severe disease significantly TCID Transmission Vaccine development viral clearance Viral pneumonia virus [DOI] 10.26508/lsa.202000886 PMC 바로가기 [Article Type] Research Article
A sprayable Acid-Oxidizing solution containing hypochlorous acid (AOS2020) efficiently and safely inactivates SARS-Cov-2: a new potential solution for upper respiratory tract hygieneMiscellaneous Published on 2021-02-112022-10-31 Journal: European archives of oto-rhino-laryngology : offic [Category] COVID-19, MERS, SARS, [키워드] Acid-Oxidizing solution (AOS2020) blocked coronavirus COVID-19 pandemic early stage Efficacy evaluate Guidance HClO highest hygiene Hypochlorous acid (HClO) in vitro indicate initial International intranasal mortality rates nasal National oral mucosa Potential treatment reduce reduced respiratory tract Result safety profile SARS-CoV-2 the disease Tolerability Transmission upper upper respiratory upper respiratory tract Viral load virucidal virus [DOI] 10.1007/s00405-021-06644-5 PMC 바로가기 [Article Type] Miscellaneous
Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models렌티바이러스 벡터를 사용한 비강내 백신은 전임상 동물 모델에서 SARS-CoV-2로부터 보호합니다Article Published on 2021-02-102022-09-12 Journal: Cell Host & Microbe [Category] MERS, SARS, 진단, [키워드] Ad5 adenoviral vector animal model approach beta-coronavirus boost boost-target coronavirus disease COVID-19 decrease Deleterious develop Effect Efficacy Evidence expression glycoprotein golden hamsters hamsters immune response immunization Immunoglobulin immunoglobulin A in vivo in vivo Ad5 transduction inhibit Injury intranasal intranasal vaccination lentiviral lentiviral vectors local inflammation log lung Lung inflammation lung viral load mice mucosal mucosal immunity Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody platform Prophylactic PROTECT receptor hACE2 reduce respiratory tract respiratory tract cell respiratory tracts respiratory tracts. SARS-CoV-2 SARS-CoV-2 replication serum systemic the SARS-CoV-2 the Spike vaccination Vaccine vaccine candidate [DOI] 10.1016/j.chom.2020.12.010 PMC 바로가기 [Article Type] Article
Localized and Systemic Immune Responses against SARS-CoV-2 Following Mucosal ImmunizationArticle Published on 2021-02-062022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] antigens avian coronavirus Bronchoalveolar lavage Coronaviruses COVID-19 cytokine elicit elicited expressing global pandemic Heterologous heterologous vaccine homologous Homologous vaccine IFN-γ IL-2 immune response Immunity immunization intranasal intranasal vaccine Local Localized lung mice mucosal mucosal immune nanovaccine neutralizing antibody nucleocapsid Plasmid Protective response responses against robust SARS-CoV-2 SARS-CoV-2 spike secreting serum spleen Support systemic T-cell T-cell Response TNFα transmission of SARS-CoV-2 USA Vaccine vaccinia [DOI] 10.3390/vaccines9020132 PMC 바로가기 [Article Type] Article
Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicityArticle Published on 2021-01-292023-06-15 Journal: Immunity [Category] MERS, SARS, [키워드] COVID-19 cytokine hamster IFN-I intranasal mRNA-seq pandemic Prophylactic therapeutic transcriptomics [DOI] 10.1016/j.immuni.2021.01.017 PMC 바로가기 [Article Type] Article
Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 MiceK18-hACE2 마우스에서 SARS-CoV-2의 비강내 접종 후 신경 침범 및 뇌염Article Published on 2021-01-192022-09-10 Journal: Viruses [Category] 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Brain brains Cell cell death Central nervous system characterized chemokines CNS Coronavirus-2 correlated COVID-19 cytokine Cytokines declined direct infection Encephalitis exhibited hACE2 hallmark hemorrhage highest humans infect cell Infection Infectious virus Inflammatory response inoculation intranasal K18-hACE2 K18-hACE2 mice leukocyte leukocyte infiltration lung Lungs mice Mortality nasal nasal turbinate Neuroinflammation neuroinvasion Neurological disease neuronal olfactory olfactory bulb Onset Pathogenesis pathogenesis of SARS-CoV-2 plaque-forming unit plaque-forming units respiratory SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe disease Viral virus titer virus titers [DOI] 10.3390/v13010132 PMC 바로가기 [Article Type] Article