Small Interfering RNA Effectively Inhibits the Expression of SARS Coronavirus Membrane Gene at Two Novel Targeting SitesArticle Published on 2010-10-182022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] analyzed blocked conserved coronavirus Critical demonstrated downregulate downregulated Effect eGFP expression Gene Expression information interferon isolate isolates M gene membrane Membrane gene novel nucleotide nucleotide substitution occur post-transcriptionally Protein qRT-PCR Quantitative Region RNA RNA molecule RT-PCR SARS-CoV SARS-CoV infection SARS-CoV M semi-quantitative sequence significantly siRNA Site Small interfering RNA targeting tested upregulation viral genome viral infection [DOI] 10.3390/molecules15107197 PMC 바로가기 [Article Type] Article
SARS-CoV Infection in a Restaurant from Palm CivetResearch Published on 2005-12-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome Analysis China circulation Civet contact with coronavirus gene sequence Guangzhou, China isolates palm civet palm civets Partial Patient positive related Research restaurant S gene SARS-CoV SARS-CoV infection Severe acute respiratory syndrome transfer viral sequence [DOI] 10.3201/eid1112.041293 PMC 바로가기 [Article Type] Research
SARS Transmission Pattern in Singapore Reassessed by Viral Sequence Variation AnalysisResearch Article Published on 2005-02-222022-10-29 Journal: PLoS Medicine [Category] Coronavirus, [키워드] accurate acquisition acute respiratory syndrome Analysis approach clinical sample clinical samples Contact demonstrated dependent on detect different Direct effective Epidemiological investigation epidemiological link Epidemiological study finding genetic analysis Genetic variation heterogeneous Host Infectious disease information isolate isolates lung tissues mass molecular nine outbreak overcome pathogen pathogen transmission Patient pattern population level problems provide quasispecy SARS Coronavirus SARS-CoV Sequence analysis sequence variation Singapore Stage thought variety Viral RNA viral sequence virus was determined [DOI] 10.1371/journal.pmed.0020043 PMC 바로가기 [Article Type] Research Article
Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003Research Article Published on 2004-09-062022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] 2003 3CLpro adjusted Analysis antigenic antigenic protein appear arising calculated Cell culture China Co-infection Complete Contact Culture cultured isolate Deletion different estimate FIVE found functional Gene Genes Genetic Genome greater group growth hotel human population human populations human tissue human-to-human transmission in vitro in vivo isolate isolates molecular Mutation mutation rate Non-synonymous mutation North nucleotide substitution ORF ORFs passage pathogen Patient per day polymerase Proteins related respiratory Result RNA virus SARS Coronavirus SARS-CoV selection pressure sequence sequenced severe Singapore Taiwan the epidemic the SARS epidemic tissue sample Transmission transmission patterns undergo Vero Cell viral genome was used whole genome sequence [DOI] 10.1186/1471-2334-4-32 PMC 바로가기 [Article Type] Research Article
Molecular analysis of the S1 subunit of the spike glycoprotein of respiratory and enteric bovine coronavirus isolatesArticle Published on 2002-01-302022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Allelic variation alteration Amino acid amino acid change amino acid substitution Analysis analyzed antigenic Bovine coronavirus Characteristics classical cleavage site Clustering compared diarrhea different Genetic group hydrophobicity isolate isolates led to nucleotide Phylogenetic analysis polymorphism predicted Probability Protein residue Respiratory and enteric BoCV S glycoprotein S1 subunit secondary structure sequence Sequencing significant changes in spike glycoprotein strain Strains the S1 subunit two subgroups variations [DOI] 10.1016/S0168-1702(02)00004-7 PMC 바로가기 [Article Type] Article