MERS-CoV – Page 20 – Communicable Diseases Research

Impaired Dendritic Cell Homing in COVID-19

Medicine

Published on 2021-11-042022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Broad Spectrum Antiviral Properties of Cardiotonic Steroids Used as Potential Therapeutics for Emerging Coronavirus Infections

Article

Published on 2021-11-022022-10-28
Journal: Pharmaceutics [Category] COVID-19,

[키워드] activity administration Analysis analyzed anti-coronavirus activity Antiviral antiviral activity antiviral drug antiviral property Calu3 cell Cardiotonic cardiotonic steroid Compound coronavirus Coronavirus infection Coronavirus infections COVID-19 death develop differentially expressed gene digitoxin dose gene expression patterns immunofluorescence indicated inhibit MERS MERS-CoV MERS-CoV infection oral bioavailability pharmacokinetics Potential property repeated SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus Seven Spectrum stability steroid suggested therapeutic Therapeutics these compounds Toxicity treated variety virus-infected cells
[DOI] 10.3390/pharmaceutics13111839 PMC 바로가기 [Article Type] Article

First direct human-to-cat transmission of the SARS-CoV-2 B.1.1.7 variant

SARS-CoV-2 B.1.1.7 변종의 첫 인간-고양이 직접 전파

Article

Published on 2021-11-012022-09-11
Journal: Australian veterinary journal [Category] SARS, 변종,

Development of a recombinant vaccine containing a spike S1-Fc fusion protein induced protection against MERS-CoV in human DPP4 knockin transgenic mice

Article

Published on 2021-10-302022-11-01
Journal: Journal of virological methods [Category] Coronavirus, MERS,

[키워드] addition alum adjuvant antigen-specific neutralizing antibody baculovirus BALB/c mice BSL, biosafety level CEF, chicken embryo fibroblast cells Chinese hamster CHO, Chinese hamster ovary coronavirus demonstrated development Dipeptidyl peptidase-4 DPP4 effective ELISA, enzyme-linked immunosorbent assay Extracellular family Coronaviridae Fc fragment Fc, fragment of crystalline Fragment of crystalline (Fc) molecule fused fusion protein genus Betacoronavirus highly pathogenic human DPP4 humoral immune response Humoral immunity IgG IgG4 immunogenicity inflammatory cell infiltration inoculated lack MERS-CoV MERS-CoV infection MERS-CoV, Middle East respiratory syndrome coronavirus MERS, Middle East respiratory syndrome mice Middle East Middle East respiratory syndrome Coronavirus Neutralizing antibodies PBS, phosphate-buffered saline PBST, phosphate-buffered saline in 0.05 % Tween 20 PCR, polymerase chain reaction PFU, plaque-forming unit Protective Protein Proteins RBD, receptor-binding domain respiratory syndrome coronavirus RLU, relative light unit S1 subunit SARS-CoV, severe acute respiratory syndrome coronavirus secretion SFM, serum-free medium Spike protein therapeutic transgenic mice Vaccine vaccine candidate Vaccine development viral challenge viral outbreak virus
[DOI] 10.1016/j.jviromet.2021.114347 PMC 바로가기 [Article Type] Article

Interspecies Jumping of Bat Coronaviruses

박쥐 코로나 바이러스의 산간 점프

Review

Published on 2021-10-292022-09-10
Journal: Viruses [Category] MERS, SARS, 치료기술,

[키워드] bat bats caused chance China Chinese Horseshoe bats coronavirus CoV COVID-19 CoVs disease disease outbreaks Epidemic epidemics/pandemics event events experiments fatality Genome genome organization genomic studies genomic study horseshoe horseshoe bats Human interspecies jumping Jumping measure MERS MERS-CoV MONITOR Mortality occurred outbreak pandemic Pandemics Patient Phylogenetic Pipistrellus Pneumonia PROTECT public health recombineering reduce reported reservoir SADS SARS SARS epidemic SARS-CoV SARS-CoV-2 SARS-related CoV Spread Threats Transmission Tylonycteris virus Wuhan Wuhan, China
[DOI] 10.3390/v13112188 PMC 바로가기 [Article Type] Review

Innate Immunity Evasion Strategies of Highly Pathogenic Coronaviruses: SARS-CoV, MERS-CoV, and SARS-CoV-2

Microbiology

Published on 2021-10-292022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

Mapping SARS-CoV-2 Antibody Epitopes in COVID-19 Patients with a Multi-Coronavirus Protein Microarray

Research Article

Published on 2021-10-272022-10-30
Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS,

[키워드] accelerated accessory protein antibody antibody binding sites antibody reactivity antigenic applied binding changes in correlated correlation COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients cross-react cross-reactivity de novo ELISAs endemic human coronavirus enzyme-linked immunosorbent assay epitope Epitopes Evidence full-length HCoV HCoV-NL63 HCoV-OC43 help Human human coronaviruses identify IgA IgG IgM immune increasingly individual infect knowledge mapping MERS-CoV Microarray microneutralization Middle East Mutant SARS-CoV-2 N proteins Numerous ORF3a ORF7a other coronavirus overlapping Patient peptide Protein Proteins reactive reactivity Region regions Research respiratory syndrome coronavirus response responses responses against SARS-CoV SARS-CoV-2 SARS-CoV-2 protein sera shown specificity Spread structural protein the antibody response vaccination Vaccine-induced immunity variants of concern viral evolution viruses was used worldwide pandemic
[DOI] 10.1128/Spectrum.01416-21 PMC 바로가기 [Article Type] Research Article

Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure

Review

Published on 2021-10-262022-10-29
Journal: mSystems [Category] COVID-19,

[키워드] affected biological system broader impact Cell conserved coronavirus coronavirus disease Coronaviruses CoV COVID-19 COVID-19 pandemic Critical Effect effort evade genomic Genomic analysis Genomics help hosts Human human CoV human host Human immune system human populations identify immune immune response infect Interaction Interpretation mechanism MERS-CoV Middle East novel coronavirus SARS-CoV-2 offer organ system other coronavirus Pathogenesis Phylogeny protective mechanisms proteomic provided Regulatory related virus Research respond review robust SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection similarity Spread Structure susceptibility Symptomatology Symptoms the disease the SARS-CoV-2 virus Transmission treat understanding variants viral pathogenesis virus while
[DOI] 10.1128/msystems.00095-21 PMC 바로가기 [Article Type] Review

Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs® 7630 in SARS-CoV-2-Infected Human Lung Cells

Pharmacology

Published on 2021-10-252022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] accompanied Affect Anti-inflammatory Antiviral antivirals assessment Calu-3 Calu-3 cell candidate CCL5 CD40L cell line cellular entry chemokine clinical study comparable Concentration coronavirus CoV COVID-19 COVID-19 therapeutics CXCL10 CXCL9 cytokine cytokine secretion Cytokine storm derivatives disease drug Duration of infection Effect elevated exhibited Extract fraction growth growth factor highly pathogenic Human human lung IC50 IL-13 IL-1β IL-6 IL-8 IL1B IL6 immune immunomodulatory function immunomodulatory properties in vitro in vivo Inflammatory response inhibited inhibiting innate immune response MERS-CoV modulation non-toxic oligomerization Particle PDGF Pelargonium pelargonium root extract (EPs® 7630) Phytomedicine Post-infection pro-inflammatory cytokine pro-inflammatory gene Prodelphinidin pseudovirus purine reduced reducing Regulation root SARS-CoV SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 propagation separated shown significantly symptom severity TNF-α TNFAIP3 upper respiratory upregulation Viral load viruses
[DOI] 10.3389/fphar.2021.757666 PMC 바로가기 [Article Type] Pharmacology

Rapid Detection of SARS-CoV-2 Using Duplex Reverse Transcription-Multienzyme Isothermal Rapid Amplification in a Point-of-Care Testing

현장 진료 테스트에서 이중 역전사-다효소 등온 급속 증폭을 사용한 SARS-CoV-2의 신속한 검출

Cellular and Infection Microbiology

Published on 2021-10-222022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] 229E 95% CI 95% confidence interval a low volume acute respiratory syndrome Adenovirus Amplicon amplicons amplification amplify buffer caused Concentration coronavirus coronavirus 229E cross-reaction detection diagnostics duplex multienzyme isothermal rapid amplification Efficacy extraction guanidinium human parainfluenza virus Influenza influenza A influenza A virus influenza B influenza B virus isothermal amplification lateral flow lateral flow dipstick limit of detection MERS MERS-CoV N gene National Negative predictive value nucleic acid nucleic acid test nucleic acid tests ORF1 ORF1ab ORF1ab gene Pathogens point-of-care testing Positive predictive value Precision Predictive value primer Primers probe probes qPCR Rapid reaction respiratory Respiratory pathogens respiratory syncytial virus RNA extraction SARS-CoV SARS-CoV-2 Severe acute respiratory syndrome specimen Spread suspected patient suspected patients Swab target temperature Testing virus Volume were used without RNA extraction
[DOI] 10.3389/fcimb.2021.678703 PMC 바로가기 [Article Type] Cellular and Infection Microbiology