mononuclear cell – Page 20 – Communicable Diseases Research

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis

바이러스-숙주 상호작용 및 단백질체 조사, SARS-CoV-2 발병에 영향을 미치는 잠재적인 독성 요인 밝혀

Article

Published on 2021-01-152022-09-11
Journal: Med (New York, N.Y.) [Category] SARS, 유전자 메커니즘,

A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein

SARS-CoV-2 스파이크 단백질의 수용체 결합 도메인을 표적으로 하는 치료 중화 항체

Article

Published on 2021-01-122022-09-10
Journal: Nature Communications [Category] 변종, 진단, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alleviate alleviation angiotensin angiotensin converting enzyme animal model antibodies antibody Antibody therapy Antibody-dependent enhancement block caused Clinical symptoms Complex crystal structure convalescent convalescent patient coronavirus COVID-19 COVID-19 patient crystal structure D614G variant enzyme evaluated hamster human monoclonal antibodies Human monoclonal antibody Infection Interaction mAb mAbs mononuclear cell mononuclear cells neutralize neutralizing antibody Orientation pandemic Peripheral blood Peripheral blood mononuclear cells RBD receptor Receptor binding domain reduce reduction in Region reported respiratory rhesus SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus Spike protein Symptom the SARS-CoV-2 therapeutic therapeutic effect therapeutic effects Therapeutics Vaccine Viral viral infection viral spike protein viral titer
[DOI] 10.1038/s41467-020-20602-5 PMC 바로가기 [Article Type] Article

High Induction of IL-6 Secretion From hUCMSCs Optimize the Potential of hUCMSCs and TCZ as Therapy for COVID-19-Related ARDS

hUCMSC에서 IL-6 분비의 높은 유도는 COVID-19 관련 ARDS에 대한 치료법으로서 hUCMSC 및 TCZ의 잠재력을 최적화합니다

Article

Published on 2021-01-012022-09-12
Journal: Cell transplantation [Category] 진단,

[키워드] acute respiratory distress analyzed anti-inflammatory effect ARDS Biological Blood Cell cellular Concentration correlation COVID-19 cytokine secretion ELISA evaluated Exogenous expression functional hUCMSC Hyperinflammatory syndrome IL-6 IL-6 level IL-6 levels IL-6 neutralizing antibody IL-6 receptor IL-6R induction Inflammation inhibited inhibitory effect interleukin-6 less Microarray mononuclear cell mRNA expression MTT Neutralizing neutralizing antibody PBMC PBMCs peripheral Potential proliferation reached reported Respiratory failure Responder Severe COVID-19 pneumonia supernatant syndrome TCZ therapeutic potential therapy Tocilizumab treat umbilical was measured was used
[DOI] 10.1177/09636897211054481 PMC 바로가기 [Article Type] Article

Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19

세로 전사체 분석은 COVID-19에서 회복하는 동안 강력한 T 세포 면역을 보여줍니다

Article

Published on 2020-12-242022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Analysis AP-1 Clinical features Clinical stages convalescence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 creation differentially expressed differentiation disease downregulated driven by event Genome informatics Humoral immunity immune protection immune regulation immune response immune responses Immunity indicated Infectious diseases long non-coding RNA longitudinal Messenger RNA messenger RNAs microRNA MicroRNAs miRNAs mononuclear cell mRNAs occurred Patient PBMC performed Peripheral blood regulatory network rehabilitation respiratory RNA sequencing robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus signaling pathway significantly T cell T-cell activation Transcriptome Treatment type I interferon type I interferon response understanding
[DOI] 10.1038/s41392-020-00457-4 PMC 바로가기 [Article Type] Article

Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression

Research Article

Published on 2020-12-242022-10-30
Journal: Life Science Alliance [Category] COVID-19, MERS, SARS,

Early Phases of COVID-19 Are Characterized by a Reduction in Lymphocyte Populations and the Presence of Atypical Monocytes

Immunology

Published on 2020-12-092022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] 28-day mortality acute respiratory syndrome Admission association Atypical CD14 CD3+ CD4+ cell CD8+ Cell cells characterized composed coronavirus coronavirus disease COVID-19 Diagnosis died early phase evaluated expression HLA-DR Immune profile immune profiling immunological change include Infection Inflammation Inflammatory biomarker IQR lymphocyte lymphocytopenia mean value median value monocyte Monocytes mononuclear cell mononuclear cells natural killer pathogen patients patients with COVID-19 Peripheral blood Peripheral blood mononuclear cells phase Population Presence preserved reduced reduction responsible Result SARS-CoV-2 side scatter subpopulation
[DOI] 10.3389/fimmu.2020.560330 PMC 바로가기 [Article Type] Immunology

A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients

Article

Published on 2020-12-082022-10-04
Journal: Cell Death Discovery [Category] 바이오마커,

[키워드] adaptive Analysis Anti-viral applied approach available data B cell Blood cell types Comorbidity complex condition coronavirus COVID-19 patient cytokine Cytokines cytolytic diabetes disease Disease progression dysregulated Gene Expression Genes healthy individual healthy individuals help heterogeneity HLA-DQA1 HLA-F Hospitalization IFN-γ IL6 immune regulation Immune status Immunity immunology increases in Infection Innate immunity Lung disease management mimicking Molecular biology mononuclear cell Neutrophils observation outcome overlapping pandemic parameter Pathways Patient patients PBMC PBMCs Peripheral blood platform Pneumonia profile reduced response RNA SARS-CoV SARS-CoV-2 patient significantly stages subset Symptom Systems biology the disease Thromboembolism TNF
[DOI] 10.1038/s41420-020-00376-x PMC 바로가기 [Article Type] Article

Thymosin Alpha 1 Reduces the Mortality of Severe Coronavirus Disease 2019 by Restoration of Lymphocytopenia and Reversion of Exhausted T Cells

티모신 알파 1은 림프구 감소증의 회복과 소진된 T 세포의 회복을 통해 심각한 코로나바이러스 질병 2019의 사망률을 감소시킵니다

Article

Published on 2020-11-192022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] (PD-1 Alpha benefit Blood CD4+ T cell CD4+ T cells CD4+ T-cell CD8+ CD8+ T cell CD8+ T cells circulation clinical benefit clinical benefits Clinical outcome clinical outcomes conditions COVID-19 COVID-19 patient COVID-19 patients domain elderly patients expression flow cytometry hospital immune immune reconstitution immune response Immunoglobulin Infection less lymphocytopenia marker mechanism mononuclear cell mononuclear cells Mortality mucin Patient PD-1 Peripheral blood Peripheral blood mononuclear cells protein 3 reduced respiratory restoration restored reversed reversion SARS-CoV-2 Severe acute respiratory syndrome severe COVID-19 severe COVID-19 patient severe COVID-19 patients significantly T cell T cells T-cell T-cell exhaustion T-cell receptor thymosin thymosin alpha 1 Treatment treatment for COVID-19 Viral viral infection viral infections was measured Wuhan Wuhan, China
[DOI] 10.1093/cid/ciaa630 PMC 바로가기 [Article Type] Article

Broncho-alveolar inflammation in COVID-19 patients: a correlation with clinical outcome

Research Article

Published on 2020-11-162022-10-28
Journal: BMC Pulmonary Medicine [Category] COVID-19, Fulltext, SARS,

[키워드] Activation acute respiratory syndrome alveolar alveolitis Anti-viral antibodies Antiviral BAL Bronchoalveolar lavage Care Cell cell count Clinical outcome Concentration conducted coronavirus correlation COVID-19 Cytokines effector feature fraction groups Hyperactivation ICU ICU patient IL10 IL6 IL8 immunostaining increase in Infection Inflammation inflammatory cascade inflammatory status interleukin intermediate lung lymphocyte Macrophage Medicine Microscopy mononuclear cell Nasopharyngeal swab neutrophil pandemic Patient patients treated patients with moderate patients with SARS-CoV-2 pro-inflammatory cytokine proportions Prospective Study reached Real-time PCR Result SARS-CoV-2 severe COVID-19 severe pneumonia significantly higher steroid supplementary material Survivors sustained Tocilizumab Transmission treated Treatment ultrastructure Variation viral particle ward was performed with COVID-19
[DOI] 10.1186/s12890-020-01343-z PMC 바로가기 [Article Type] Research Article

Placental Pathology of COVID-19 with and without Fetal and Neonatal Infection: Trophoblast Necrosis and Chronic Histiocytic Intervillositis as Risk Factors for Transplacental Transmission of SARS-CoV-2

태아 및 신생아 감염이 있거나 없는 COVID-19의 태반 병리: SARS-CoV-2의 경태반 전파에 대한 위험 인자로서의 영양막 괴사 및 만성 조직구간 융모염

Review

Published on 2020-11-152022-09-10
Journal: Viruses [Category] SARS, 유전자 메커니즘,

[키워드] appear Cell characterized chronic chronic histiocytic intervillositis co-occurrence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 criteria Effect etiological agent Factor fetal fetal COVID-19 infection finding immunohistochemistry In situ hybridization Infant Infection Inflammation Interpretation intervillous space maternal COVID-19 infection maternal-fetal COVID-19 mononuclear cell mother Necrosis neonatal COVID-19 infection Neonate nucleic acid pathology pathophysiology Placenta placental COVID-19 infection Placental infection placental pathology placental risk factors Placentas positive potential mechanism pregnant women risk factor RNA SARS-CoV-2 Spectrum syncytiotrophoblast Transplacental transplacental COVID-19 infection trophoblast trophoblast necrosis uninfected Variability vertical transmission Viral Viral antigen viral antigens viral nucleic acid Viral transmission with COVID-19
[DOI] 10.3390/v12111308 PMC 바로가기 [Article Type] Review