pro-inflammatory cytokine – Page 20 – Communicable Diseases Research

Low serum calcium: a new, important indicator of COVID-19 patients from mild/moderate to severe/critical

Virology

Published on 2020-12-232022-10-28
Journal: Bioscience Reports [Category] COVID-19,

SARS-CoV-2 and Viral Sepsis: Immune Dysfunction and Implications in Kidney Failure

Review

Published on 2020-12-152022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] abdominal pain ACE-2 Acute cardiac injury Acute kidney injury acute respiratory distress acute respiratory syndrome addition affected AKI antiviral medicine ARDS binding cardiovascular complication Cell clinical manifestation Clinical outcome co-morbidity coronavirus coronavirus disease cough COVID-19 COVID-19 patient dysfunction Dyspnea effective Endothelial dysfunction Evidence exacerbate explained failure Fever Host human Angiotensin-converting enzyme Hyperinflammatory ICU include infected with COVID-19 Inflammatory response inhibit intensive care unit Intervention kidney dysfunction lung mechanism modulate Mounting multi-organ failure Occurrence organ outcome overexpression pathogenic mechanism Patient pro-inflammatory cytokine Probability receptor renal renal dysfunction renal impairment reported Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike Sepsis severe COVID-19 Severe patient severity shown Support syndrome systemic inflammatory response the cytokine storm the disease treating COVID-19 Vaccine viral cytopathic effect viral entry viral replication Wuhan, China
[DOI] 10.3390/jcm9124057 PMC 바로가기 [Article Type] Review

Challenges and Opportunities from Targeting Inflammatory Responses to SARS-CoV-2 Infection: A Narrative Review

Review

Published on 2020-12-122022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] “cytokine storm” acute respiratory syndrome Anti-inflammatory anti-inflammatory drug Anti-inflammatory drugs anti-viral drug approach benefit Care challenge clinical care Clinical practice clinical trial clinician complementary condition Coronavirus-2 COVID-19 COVID-19 disease COVID-19 patient Cytokine storm develop disease severity drug early stage effective effective therapy effort Evidence expected global pandemic Host Hypothesis immune defense immunomodulation immunomodulatory activities Infection Inflammation Inflammatory introduced management morbidity and mortality narrative novel coronavirus disease opportunity patients pro-inflammatory cytokine Replication Research response review risk Safe SARS-CoV-2 SARS-CoV-2 entry severe cases Spread targeting the disease therapy Vaccines virus while worsening
[DOI] 10.3390/jcm9124021 PMC 바로가기 [Article Type] Review

Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19

증가된 인터루킨-6 및 대식세포 chemoattractant protein-1은 COVID-19의 호흡 부전과 관련이 있습니다

Clinical Trial

Published on 2020-12-102022-08-13
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 진단,

[키워드] analyzed association AUC benefit best Biomarker Biomarkers blood sample Blood samples clinical Clinical data collected Combination combinations correlated COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines defined FiO2 G-CSF Hospitalization hospitalized patients Human ICU identify IL-1ra IL-6 IL-8 Inclusion Increased Infectious diseases intensive care unit interleukin-6 investigated IP-10 Macrophage MCP-1 MIP-1α P/F PaO2 PaO2/FiO2 ratio Patient Plasma cytokine pro-inflammatory cytokine pro-inflammatory cytokines prospective cohort study recruited Respiratory failure risk ROC analyses ROC analysis SARS-COV-2 infection severe COVID-19 systemic cytokine target targets treated Treatment Treatment strategies
[DOI] 10.1038/s41598-020-78710-7 PMC 바로가기 [Article Type] Clinical Trial

NF-κB Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients

Immunology

Published on 2020-12-102022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, 신종인플루엔자,

[키워드] acute respiratory distress amplifying approach cascade cell interaction cellular chemokine chemokines clinical manifestation cough COVID-19 COVID-19 patients Critical cytokine Cytokine storm Cytokines death dysregulated Effect elevated expected febrile illness Hypothesis infected with SARS-CoV-2 Inflammatory response Mild Mild symptom much higher multiple organ failure NF-kappaB NF-κB NSAID pathway Patient Perspective Potential Prevent pro-inflammatory pro-inflammatory cytokine proteasome inhibitor provide SARS-CoV-2 (2019-nCoV) severity Severity of disease Stage syndrome synergistic target Therapeutic approach therapeutic potential triggering
[DOI] 10.3389/fimmu.2020.598444 PMC 바로가기 [Article Type] Immunology

The Role of MSC Therapy in Attenuating the Damaging Effects of the Cytokine Storm Induced by COVID-19 on the Heart and Cardiovascular System

Cardiovascular Medicine

Published on 2020-12-092022-10-31
Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19,

[키워드] acute respiratory distress acute respiratory syndrome alleviate appear ARDS attenuate Cardiac arrhythmia cardiovascular cardiovascular complications cardiovascular system cause caused Cell clinical study Complication coronavirus coronavirus disease COVID-19 COVID-19 patients COVID-19 positive patient CXCL10 Cytokine storm deaths develop drug Effect elevated global pandemic hallmark heart help IL-2 IL-22 IL-6 IL-7 immune system immunomodulatory Immunosuppression induced infected case Infection lung Mesenchymal stem cells Mortality MSC MSCs myocardial injury myocarditis organ systems Patient Prevent primary site pro-inflammatory cytokine regeneration and repair role SARS-CoV-2 Severe case shown storm stromal cell suggested syndrome System the cytokine storm therapy Thromboembolism tissue repair TNFα
[DOI] 10.3389/fcvm.2020.602183 PMC 바로가기 [Article Type] Cardiovascular Medicine

A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection

네트워크 기반 분석은 SARS-CoV-2 감염에서 사이토카인 폭풍과 바이러스를 억제하는 비타민 D의 기본 메커니즘을 보여줍니다.

Immunology

Published on 2020-12-092022-09-11
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, 치료제,

[키워드] 2019 activating Antiviral antiviral response approach bind bioinformatics cause Cell Cluster Combination coronavirus COVID-19 Critical cytokine Cytokine storm Cytokines Defense depth analysis differentially expressed epithelial experimental validation expression Extensive fibrosis finding Functional enrichment analysis generate Genes highest host gene host genes host response human immune response IFN-α immune in-depth analysis infect Inflammatory Inflammatory response inhibit initiate ISGs leads Lower respiratory tract Lung fibrosis MCODE score mechanism molecular mechanism NFkB1 NHBE Organ failure pandemic pathway Pathways Patient potential mechanism POU2F2 pro-inflammatory cytokine pro-inflammatory cytokines protein-protein interaction receptor reducing referred to Regulation regulatory network respiratory Result resulting RNA sequencing robust antiviral response SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patients severe pneumonia Signaling signaling pathway STAT Stat1 STAT2 STAT3 storm suggested Suppressing Systems biology the cells the cytokine storm TNF transcription factor transcription factors Transcriptome Tuberculosis up-regulated Viral viral infection Vitamin Vitamin D were used
[DOI] 10.3389/fimmu.2020.590459 PMC 바로가기 [Article Type] Immunology

Novel Molecular Evidence Related to COVID-19 in Patients with Diabetes Mellitus

Review

Published on 2020-12-072022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] ACE2 acute respiratory syndrome affected aggravate angiotensin-converting enzyme 2 anti-inflammatory effect Asymptomatic COVID-19 Autoimmune benefit binding caused Cell cleavage clinical trial coronavirus Coronavirus disease 2019 COVID-19 COVID-19 progression cytosolic Diabetes Mellitus Dipeptidyl peptidase-4 Effectiveness Evidence exhibit facilitate furin global pandemic glycemic control glycosylation Hospitalization human Angiotensin-converting enzyme hyperglycemia immune response induce inhibitor Injury innate immune system Innate immunity Lactate lower mortality medication metabolites Mild novel outcomes pancreatic Patient patients with diabete pro-inflammatory cytokine protective effect Randomized receptor reduction in renin–angiotensin–aldosterone system S protein SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 susceptibility targets Th1 Th2 immunity the S protein TMPRSS2 transmembrane serine protease Treatment Trigger uncontrolled vicious cycle viral entry viral genome viral S protein
[DOI] 10.3390/jcm9123962 PMC 바로가기 [Article Type] Review

Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles

SARS-CoV-2 및 ORF8이 결여된 382-nt 결실 분리주에 의한 인간 비강 상피 세포의 감염은 유사한 바이러스 동역학 및 숙주 전사 프로필을 나타냅니다

Research Article

Published on 2020-12-072022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 유전자 메커니즘, 치료기술,

[키워드] absence airway airway epithelial cells anti-viral gene up-regulation anti-viral signaling pathway anti-viral signaling pathways apical side basolateral secretion causative agent cell type cell types comparable conserved expression coronavirus disease Coronavirus disease 2019 CoV COVID-19 COVID-19 patients CXCL10 CXCL10 production cytokine cytokine production Cytokines differentiated NEC differentiated NECs distinct gene subset distinct gene subsets Duration of infection early response elevated elicited epithelial epithelial cell epithelial cells examined genomes global healthcare greater magnitude H3N2 healthy nasal-tissue highlight Host host gene expression Host immune response Host transcriptional response host-response hours post-infection hpi IL-6 Immune cell infiltration immune cells immune response impair in vitro In-vitro infancy infected cells infected NEC infected NECs Infection Infection of NEC Infection of NECs Infection with Δ382 infiltrating immune cell infiltrating immune cells Inflammatory response Influenza influenza strain late time-point late time-points less modulating Nasal Epithelial cells NECs Novel coronavirus novel coronavirus SARS-CoV-2 ORF8 other SARS-CoV-2 genes Pathogenesis patient sera patients plasticity post-infection time-point pro-inflammatory cytokine pro-inflammatory cytokines released reported reveal SARS-CoV-2 SARS-CoV-2 and Δ382 infection SARS-CoV-2 genes SARS-COV-2 infection Screening severe disease significantly similar replication kinetics similarities similarity Singapore stem cell stem cells subsequent cytokine production temporal up-regulation therapeutic node TNFα transcriptional transcriptional profile Transcriptome transcriptome analysis transcripts transcripts mapping understanding Viral viral clearance viral kinetics virus particle virus particles wild-type and Δ382 wild-type SARS-CoV-2 Δ382 Δ382 infected cell Δ382 infected cells Δ382 infection
[DOI] 10.1371/journal.ppat.1009130 PMC 바로가기 [Article Type] Research Article

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

Research

Published on 2020-12-042022-10-05
Journal: Nature Immunology [Category] SARS, 바이오마커, 임상, 치료기술, 치료법,

[키워드] antiviral immunity antiviral response blood transcriptome Characteristics Concentration contrary contributing to coronavirus disease correlated COVID-19 Critical disease Critically ill Critically ill patient critically ill patients cytokine death disease severity exhibited faster flu fraction Hospitalization Hospitalized Host hyperinflammation IFN IFN-λ IL-8 Immunity incidence Inflammation Inflammatory cytokine interferon moderate-to-severe patient Mortality Necrosis outcome Patient patients with COVID-19 patients with influenza Pneumonia pro-inflammatory pro-inflammatory cytokine produced reflected Respiratory failure Symptoms TNF Type I IFN viral clearance Viral load viral presence with COVID-19
[DOI] 10.1038/s41590-020-00840-x [Article Type] Research