Cutting Edge: Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity최첨단: 뉴클레오캡시드 백신은 스파이크 독립적인 SARS-CoV-2 보호 면역을 유도합니다Article Published on 2021-07-152022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Adenovirus challenge concern coronavirus Coverage COVID-19 pandemic Cutting defined effector mechanisms epitope expressing focus hamster immune K18-hACE2 mice mice mucosa neutralize Neutralizing nucleocapsid protective immunity Protein rationale recall Receptor binding domain reduced respiratory respiratory mucosa response responsible SARS-CoV-2 SARS-CoV-2 vaccines severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Support T cell target the SARS-CoV-2 vaccination Vaccine vaccine immunity variants Viral Viral load weight loss [DOI] 10.4049/jimmunol.2100421 PMC 바로가기 [Article Type] Article
Neutralizing Antibodies in COVID-19 Patients and Vaccine Recipients after Two Doses of BNT162b2BNT162B2의 2 회 용량 후 COVID-19 환자 및 백신 수용자의 중화 항체Article Published on 2021-07-142022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] All participants analyzed anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody BNT162b2 Complete Covid patients COVID-19 COVID-19 patient COVID-19 patients Diagnosis dose dose regimen first dose generate Humoral response individual infected individual infected individuals long-term kinetics mild patient NAb nAb response NAb titer NAbs neutralization test Neutralizing antibodies neutralizing antibody neutralizing capacity of BNT162b2 P -value participant Participants Patient positive protective immunity pseudovirus recipient recipients remained SARS-CoV-2 second dose serology assays significantly higher surrogate virus neutralization test sVNT vaccinated individuals Vaccine virus neutralization test VNT [DOI] 10.3390/v13071364 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific immune response in COVID-19 convalescent individualsCOVID-19 회복기 개인의 SARS-CoV-2 특이 면역 반응Article Published on 2021-07-072022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] 진단, 치료기술, [키워드] Activation affected Analysis Antigen Blood CD8+ T cell cell count cell counts cellular immunity Cohort collected convalescent individual convalescent individuals coronavirus disease Coronavirus disease 2019 correlated COVID-19 discharged patients disease severity effective Follow-up analysis healthy donors humoral IgG antibodies immune response Immunological disorders implication Infectious diseases investigated natural killer neutralizing antibody NK cells Pathogenesis pathogenesis of COVID-19 Patient peptide positive protective immunity provide SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection significantly specimen suggested survival T cell T cells tested Vaccine [DOI] 10.1038/s41392-021-00686-1 PMC 바로가기 [Article Type] Article
Longitudinal Analysis of Human Memory T-Cell Response According to the Severity of Illness up to 8 Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection중증급성호흡기증후군 코로나바이러스 2 감염 후 최대 8개월까지 질병의 중증도에 따른 인간 기억 T 세포 반응의 종단 분석Article Published on 2021-07-022022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, 치료법, [키워드] 8 months acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antigen Asymptomatic Asymptomatic disease CD4+ T cell CD4+ T-cell coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 cytometry analysis Flow cytometry analysis Frequency greater healthy volunteer healthy volunteers Human illness Longevity longitudinal membrane membrane protein memory memory response memory T-cell response Mild Mild disease mononuclear cell mononuclear cells Month nucleocapsid Patient patients with COVID-19 PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells persist post-symptom onset protective effect protective immunity PSO Reinfection respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus severe disease severity severity of illness T cell T cells T-cell T-cell Response T-cell responses understanding vaccination with mild disease [DOI] 10.1093/infdis/jiab159 PMC 바로가기 [Article Type] Article
COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challengeArticle Published on 2021-07-022023-06-16 Journal: Immunity [Category] MERS, SARS, [키워드] COVID-19 mRNA vaccine mRNA-1273 Neutralizing antibodies protective immunity SARS-CoV-2 T cells type 2 responses vaccine-associated enhanced respiratory disease [DOI] 10.1016/j.immuni.2021.06.018 PMC 바로가기 [Article Type] Article
Estimating the Cumulative Incidence of SARS-CoV-2 Infection and the Infection Fatality Ratio in Light of Waning Antibodies항체 감소에 따른 SARS-CoV-2 감염 누적 발생률 및 감염 치사율 추정Article Published on 2021-07-012022-09-11 Journal: Epidemiology (Cambridge, Mass.) [Category] SARS, 진단, 치료기술, 치료제, [키워드] acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjust antibodies antibody approach average Connecticut coronavirus credible interval cross-sectional cumulative cumulative incidence declined detectable estimate estimation expected expected levels facilitate fatality help identify IFR Immunoglobulin immunoglobulins incidence Infection infections LIGHT magnitude measure mortality data New York City protective immunity Ratio reached reported respiratory SARS-CoV-2 SARS-COV-2 infection Seroconversion serologic assay serologic assays serology serology tests seroreversion severe acute respiratory syndrome Coronavirus spring [DOI] 10.1097/EDE.0000000000001361 PMC 바로가기 [Article Type] Article
Immunological memory and neutralizing activity to a single dose of COVID-19 vaccine in previously infected individuals이전에 감염된 개인의 COVID-19 백신 1회 투여에 대한 면역학적 기억 및 중화 활성Article Published on 2021-07-012022-09-12 Journal: International Journal of Infectious Diseases [Category] SARS, 진단, [키워드] Antibody Response B-cell baseline CD4 CD8+ CD8+ T-cell central memory chemiluminescence COVID-19 COVID-19 vaccine effector memory Efficacy elicited enrolled exposure group flow cytometry generate healthcare worker Immunological memory individual infected individual memory memory B-cell Memory B-cells memory T Memory T-cells mRNA vaccine naïve Neutralizing activity neutralizing antibody Neutralizing antibody response positive protective immunity SARS-CoV-2 SARS-CoV-2 infected individual SARS-COV-2 infection single dose Single-dose T-cell vaccination [DOI] 10.1016/j.ijid.2021.05.034 PMC 바로가기 [Article Type] Article
COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operativelyCOVID-19(SARS-CoV-2) 림프구 반응은 수술 전 총 관절 교체 수술 후보의 염증성 바이오마커와 관련이 있습니다Research Article Published on 2021-06-302022-09-10 Journal: Journal of Orthopaedic Surgery and Research [Category] MERS, SARS, 바이오마커, 치료법, [키워드] addition analyzed antibodies antibody antibody production Blood candidate Cohort coronavirus COVID-19 cross-reactivity elective surgeries Elective surgery exhibited exposure to General population IgG antibodies IgG antibody IL-1ra IL-1β IL-6 Immunity Inflammatory biomarker inflammatory biomarkers joint LTT lymphocyte lymphocyte response lymphocyte responses Lymphocytes median age memory nucleocapsid nucleocapsid protein Nucleocapsid proteins parameter Patient peripheral Peripheral blood positive pre-vaccination pro-inflammatory biomarkers profiles protective immunity Protein reactive reactivity recent Registered response Result Retrospective study risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 nucleocapsid SARS-CoV-2 virus serum spike and nucleocapsid proteins Spike protein Spike proteins T cell T cell memory the SARS-CoV-2 the SARS-CoV-2 virus the Spike the spike protein TNFα Total Total joint arthroplasty Trial registration vaccination vaccination Methods [DOI] 10.1186/s13018-021-02563-7 PMC 바로가기 [Article Type] Research Article
Single-Dose Immunization With a Chimpanzee Adenovirus-Based Vaccine Induces Sustained and Protective Immunity Against SARS-CoV-2 Infection침팬지 아데노바이러스 기반 백신으로 1회 접종하면 SARS-CoV-2 감염에 대해 지속적이고 보호적인 면역이 유도됩니다Immunology Published on 2021-06-282022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] Adenovirus Against BALB/c mice binding Chimpanzee Chimpanzee adenovirus vector COVID-19 decrease demonstrated develop domain effective expressing full-length High-dose immunization in viral induce Infectious virus intramuscular less live SARS-CoV-2 Lung pathology Lungs Neutralizing antibody response pandemic coronavirus protective effect protective immune response protective immunity RBD reduced rhesus macaques RNA copy robust Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine sequence serotype Single-dose single-dose immunization Spike protein sustained Vaccine vaccine candidate [DOI] 10.3389/fimmu.2021.697074 PMC 바로가기 [Article Type] Immunology
COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variantsCOVID-19 mRNA 백신 유도된 3가지 SARS-CoV-2 변이체에 대한 항체 반응Observational Study Published on 2021-06-282022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 임상, 진단, [키워드] Affect antibodies Antibody Response B.1.1.7 B.1.1.7 variant B.1.351 B.1.351 variant BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine BNT162b2 vaccine circulating circulating SARS-CoV-2 variants Clinical use COVID-19 COVID-19 patients COVID-19 vaccine cross-neutralization D614G substitution Efficacy Evidence exceeded Health care Health care worker health care workers induce mRNA vaccine Mutation neutralization neutralize Neutralizing antibodies neutralizing antibody not affected protective immunity provide raised Re-infection reduced reduction RNA vaccines SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV2 second dose sera seronegative vaccinee seronegative vaccinees show specific neutralizing antibodies Spike protein the SARS-CoV-2 the spike protein titre Vaccine vaccine candidate vaccine candidates vaccine efficacy variant [DOI] 10.1038/s41467-021-24285-4 PMC 바로가기 [Article Type] Observational Study