Immunodominant and Neutralizing Linear B-Cell Epitopes Spanning the Spike and Membrane Proteins of Porcine Epidemic Diarrhea VirusImmunology Published on 2022-01-192022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] amino acid sequence B-cell epitope cause Complete consensus sequence contribute demonstrated disease ELISA testing epidemic diarrhea epitope Epitope prediction genetic diversity greater group high mortality rate identify immune stimulation immunodominant epitope immunoinformatics insight linear linear B-cell epitope M protein membrane membrane protein NCBI database neutralization Neutralizing neutralizing epitope nine offer PEDV peptide peptide-based immunoassays Porcine epidemic diarrhea virus predicted profile Protein Proteins provided retrieved S2 subunit sera Seven Spike protein strain Strains the S protein the Spike Vaccine virus Virus neutralization [DOI] 10.3389/fimmu.2021.785293 PMC 바로가기 [Article Type] Immunology
Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic dataArticle Published on 2022-01-192022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] advance Algorithm can be used Cancer cancer cell Cancer genomics Cell cell population cell type classical Computational models dataset defined estimate expression flexible Gene Expression granular heterogeneity identify immune immune response lung tumors mapping marker Proteins quantification Region resolved single cell sequencing Statistical methods tissue transcriptomic data transcriptomics tumors Tumour immunology [DOI] 10.1038/s41467-022-28020-5 PMC 바로가기 [Article Type] Article
Alphacoronaviruses Are Common in Bats in the Upper Midwestern United StatesArticle Published on 2022-01-192022-10-28 Journal: Viruses [Category] COVID-19, Fulltext, 조류인플루엔자, [키워드] acute diarrhea acute respiratory syndrome alphacoronavirus Analysis analyzed bat bat virus bats characterized circulation common coronavirus CoV CoVs downstream epidemic diarrhea Eptesicus evidenced Genome genome sequence humans Mountain nucleocapsid PCR Protein Proteins Rabies virus RT-PCR SARS-CoV SARS-CoV-2 similarity South South Korea spike gene submitted Surveillance syndrome United State upper virus widespread zoonotic [DOI] 10.3390/v14020184 PMC 바로가기 [Article Type] Article
Two short low complexity regions (LCRs) are hallmark sequences of the Delta SARS-CoV-2 variant spike protein두 개의 짧은 LCR(저복잡도 영역)은 Delta SARS-CoV-2 변이 스파이크 단백질의 특징적인 서열입니다.Article Published on 2022-01-182022-09-10 Journal: Scientific Reports [Category] SARS, 변종, [키워드] analyzed cellular conserved contagious D950N Delta delta variant furin furin cleavage site hallmark host immune system HR1 domain Iota LCR molecular evolution opens other variant other variants P681R peptide Point mutation prevalent Protein protein sequence protein sequences Proteins proteome Region reported residues SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence signal peptide spike Spike protein Spike protein sequence Spread the signal peptide the Spike the spike protein viral evolution viruses [DOI] 10.1038/s41598-022-04976-8 PMC 바로가기 [Article Type] Article
Plant-Based Vaccines in Combat against Coronavirus DiseasesReview Published on 2022-01-182022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Administered antigens applied biopharming caused combat Coronaviruses CoV COVID-19 COVID-19 pandemic Diseases DNA and RNA evaluated expression glycosylated immunodominant epitope immunogenicity inactivated viruses indicate injection membrane MERS MERS-CoV Middle East mucosa mucosal nasal Oral vaccine plant plant-based vaccines plants processed produced Protein Proteins purification purified Research respiratory Respiratory system SARS-CoV SARS-CoV-2 subunit tissue transgenic transient expression Vaccine Vaccines variant Viral vector [DOI] 10.3390/vaccines10020138 PMC 바로가기 [Article Type] Review
COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism ImpairmentArticle Published on 2022-01-182022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] Affect Alter antioxidant antioxidant system catalase cells complications consequence COVID-19 COVID-19 group COVID-19 infection dismutase Effect explain expression ferritin fetal group Health increase in iron Maternal mechanism metabolism negative influence no difference outcome oxidative stress oxygen supply pandemic pathogenic Placenta placental Pregnancy pregnant women proportion Proteins reached Research Result serum was recorded were recorded women [DOI] 10.3390/antiox11020184 PMC 바로가기 [Article Type] Article
Integrative COVID-19 biological network inference with probabilistic core decompositionArticle Published on 2022-01-172022-10-04 Journal: Briefings in Bioinformatics [Category] SARS, 신약개발, [키워드] acute respiratory syndrome addition Comorbidities connection contribute core Core Decomposition coronavirus COVID-19 Data analysis Data mining database death disease enrichment analysis evaluate gene function generate Genes graph Graph theory help hypothese hypotheses identify in silico Inference information knowledge network Network Inference. overlap PPI PPI network Protein protein interactions protein-protein interaction Proteins responsible SARS-CoV-2 Support targeting gene tissue virus [DOI] 10.1093/bib/bbab455 PMC 바로가기 [Article Type] Article
Binding behavior of spike protein and receptor binding domain of the SARS-CoV-2 virus at different environmental conditionsArticle Published on 2022-01-172022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] acute respiratory syndrome affecting association binding binding kinetics Biochemistry BLI changes in China Concentration conditions coronavirus COVID-19 pandemic effect of temperature environmental condition exhibit fatty acids full-length S hydrophobic hydrophobic surface hydrophobic surfaces Increasing ions Molecular dynamics simulation Novel coronavirus performed Protein protein concentration Proteins RBD RBD of SARS-CoV-2 Receptor binding domain Research S protein SARS-CoV-2 separated Spike protein temperature the S protein the SARS-CoV-2 virus trimer [DOI] 10.1038/s41598-021-04673-y PMC 바로가기 [Article Type] Article
In Silico Studies on Psilocybin Drug Derivatives Against SARS-CoV-2 and Cytokine Storm of Human Interleukin-6 ReceptorSARS-CoV-2 및 인간 인터루킨-6 수용체의 사이토카인 폭풍에 대한 실로시빈 약물 유도체에 대한 실리코 연구Immunology Published on 2022-01-142022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] Against Antibacterial anticancer Antiviral binding change chemotherapeutic agent chemotherapeutic agents Compound COVID-19 cytokine Cytokine storm derivative drug free energy Gibbs free energy Human inhibit inhibitors inhibitors of SARS-CoV-2 interleukin-6 interleukin-6 receptor malignancy metabolite Mprotease mushroom over Proteins psilocin psilocybin psilocybine reduce SARS-CoV-2 screened storm suggested therapeutic [DOI] 10.3389/fimmu.2021.794780 PMC 바로가기 [Article Type] Immunology
Potential Anionic Substances Binding to Platelet Factor 4 in Vaccine-Induced Thrombotic Thrombocytopenia of ChAdOx1-S Vaccine for SARS-CoV-2Immunology Published on 2022-01-122022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Adenovirus Analysis anionic anionic substances antibodies Antigen association autoantibody ChAdOx1-S ChAdOx1-S vaccine characterized component DNA Express expressed Factor FIVE glycoprotein PF4 Potential Protein Proteins recent SARS-CoV-2 substance susceptible individual the S protein the vaccine thrombocytopenia thrombosis thrombotic triggered tween vaccination Vaccine vaccine-induced thrombotic thrombocytopenia (VITT) Venous thrombosis [DOI] 10.3389/fimmu.2021.782335 PMC 바로가기 [Article Type] Immunology