DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonistsDAMP/PAMP는 COVID-19 환자에서 단핵구 TLR 활성화 및 내성을 유도합니다. 핵산 결합 스캐빈저는 이러한 TLR 작용제에 대항할 수 있습니다.Article Published on 2022-04-012022-09-12 Journal: Biomaterials [Category] COVID19(2023년), SARS, 진단, [키워드] Activation agonist anti-viral response binding Blood CD16 COVID-19 COVID-19 patient COVID-19 patients damage Deceased Ex vivo hallmark hyperactivate Hyperactivation hyperinflammation Hyperstimulation ICU ICU patient immunopathology induce Infection Inflammation innate immune intensive care unit limit lung Lungs Major-biological sciences Minor-immunology and inflammation. monocyte Monocytes neutralize nucleic acid outcome patients pattern phenotype proteomics receptors RNA-sequencing SARS-CoV-2 Signaling systemic inflammation the patient TLR TLR agonist TLR stimulation Tolerance Toll-like receptor Treatment viruses [DOI] 10.1016/j.biomaterials.2022.121393 PMC 바로가기 [Article Type] Article
Longitudinal Plasma Proteomics Analysis Reveals Novel Candidate Biomarkers in Acute COVID-19세로형 플라즈마 단백질체학 분석, 급성 코로나19에서 새로운 후보 바이오마커 밝혀Article Published on 2022-04-012022-09-11 Journal: Journal of Proteome Research [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, [키워드] abundance ACEi acquisition Activation acute COVID-19 acute inflammatory response Admission amyloid Analysis angiotensin angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitors ARB baseline Blood blood plasma candidate cascade cell proliferation complement Complement activation COVID-19 COVID-19 patients decrease degranulation exposure to fluctuation followed by fructose functions healthy control healthy controls healthy individual healthy individuals host response humoral immune response Infection Inflammatory Inflammatory response inhibitors longitudinal longitudinal analysis mechanism mechanisms nonsurvivors novel on admission pathophysiology Patient patients Platelet profile Protein Proteins proteomic proteomics Quantitative Receptor Blockers Regulation smooth muscle survivor targeted quantitative proteomics. [DOI] 10.1021/acs.jproteome.1c00863 PMC 바로가기 [Article Type] Article
SARS-CoV-2 3CLpro whole human proteome cleavage prediction and enrichment/depletion analysisArticle Published on 2022-03-282023-06-14 Journal: Computational biology and chemistry [Category] COVID19(2023년), MERS, SARS, [키워드] 3CLpro coronavirus COVID-19 machine learning neural networks protease proteomics SARS-CoV-2 [DOI] 10.1016/j.compbiolchem.2022.107671 PMC 바로가기 [Article Type] Article
Protocol for global proteome, virome, and metaproteome profiling of respiratory specimen (VTM) in COVID-19 patient by LC-MS/MS-based analysisLC-MS/MS 기반 분석을 통한 COVID-19 환자의 호흡기 표본(VTM)의 글로벌 프로테옴, 바이롬 및 메타프로테옴 프로파일링을 위한 프로토콜Article Published on 2022-03-182022-09-11 Journal: STAR protocols [Category] SARS, 신종인플루엔자, 유전자 메커니즘, [키워드] Analysis Bacterial Bioinformatics analysis Complete COVID-19 patient COVID-19 patients digestion downstream H1N1 H1N1 patients Health Sciences High-resolution Host include Major mass mass spectrometry Patient peptides Protein proteome proteomics protocol provided quantification specimen virus inactivation VTM with COVID-19 [DOI] 10.1016/j.xpro.2021.101045 PMC 바로가기 [Article Type] Article
Specialized interferon action in COVID-19코로나19에 특화된 인터페론 작용Article Published on 2022-03-152022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 유전자 메커니즘, 진단, [키워드] Activation Antiviral association C-reactive protein cell types circulating clinical marker clinical markers COVID-19 COVID-19 pathology CyTOF cytokine diagnostic disease severity Effect endothelial damage example Hospitalization hospitalized COVID-19 patients IFN IFN signaling IFNA2 IFNA6 IFNB1 IFNg IFNs Immune cell immune cell types immune cells immune marker Impact Implications interferon Kynurenine Kynurenine pathway lymphocyte lymphoid marker neutrophil pathology platelet activation poor prognosis Protective proteomics SARS-CoV-2 Seroconversion severe disease Signaling significant decrease subset the strongest therapeutic transcriptional response type I unique [DOI] 10.1073/pnas.2116730119 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Membrane Protein: From Genomic Data to Structural New InsightsArticle Published on 2022-03-102023-06-14 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, [키워드] Genomics proteomics SARS-CoV-2 [DOI] 10.3390/ijms23062986 PMC 바로가기 [Article Type] Article
A new mass spectral library for high-coverage and reproducible analysis of the Plasmodium falciparum –infected red blood cell proteome플라스모디움 팔시파룸 감염 적혈구 단백질체의 고커버리지 및 재현 가능한 분석을 위한 새로운 질량 스펙트럼 라이브러리Article Published on 2022-03-072024-08-01 Journal: GigaScience [Category] 말라리아, [키워드] data-dependent acquisition data-independent acquisition LC-MS/MS malaria Plasmodium falciparum proteomics red blood cells [DOI] 10.1093/gigascience/giac008 PMC 바로가기
A blood atlas of COVID-19 defines hallmarks of disease severity and specificityArticle Published on 2022-03-032023-06-14 Journal: Cell [Category] MERS, SARS, [키워드] Blood coronavirus COVID-19 epigenetics immune Multi-omics Personalized medicine proteomics SARS-CoV-2 transcriptomics [DOI] 10.1016/j.cell.2022.01.012 PMC 바로가기
Multiple early factors anticipate post-acute COVID-19 sequelae여러 초기 요인으로 인해 급성 COVID-19 후유증이 예상됩니다.Article Published on 2022-03-032022-09-11 Journal: Cell [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, [키워드] antibodies association Auto-antibodies CD8 chronic condition chronic conditions Clinical data Computational biology convalescence convalescent COVID-19 COVID-19 diagnosis COVID-19 patient detectability diabetes Diagnosis disease early disease Epstein-Barr virus exhibited exhibiting Factor immune immune states immune system Immunity immunological immunology initial Long COVID metabolomics multi Multi-omics Multiple PASC Patient proteomics resolved risk factor RNAemia SARS-CoV-2 severity Single Cell single-cell single-cell CITE-seq single-cell RNA-seq single-cell secretome single-cell TCR-seq Symptoms T cell T cells Transcriptome Treatment strategies type 2 diabetes unique Viremia virus [DOI] 10.1016/j.cell.2022.01.014 PMC 바로가기 [Article Type] Article
Using Omics to Study Leprosy, Tuberculosis, and Other Mycobacterial Diseasesarticle Published on 2022-02-282024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 한센병, [키워드] Genomics leprosy Lipidomics metabolomics mycobacteria proteomics transcriptomics Tuberculosis [Article Type] article