SARS-CoV-2 strain – Page 20 – Communicable Diseases Research

A computational approach to design potential siRNA molecules as a prospective tool for silencing nucleocapsid phosphoprotein and surface glycoprotein gene of SARS-CoV-2

SARS-CoV-2의 뉴클레오캡시드 인단백질 및 표면 당단백질 유전자를 억제하기 위한 전향적 도구로서 잠재적인 siRNA 분자를 설계하기 위한 컴퓨터 접근 방식

Article

Published on 2021-01-012022-08-31
Journal: Genomics [Category] MERS, SARS, 신약개발, 치료법,

Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection

무료 SARS-CoV-2 스파이크 단백질 S1 입자는 COVID-19 감염의 병인에서 역할을 할 수 있습니다

Hypothesis

Published on 2020-12-302022-09-01
Journal: Biochemistry. Biokhimiia [Category] SARS, 변종, 진단,

[키워드] accompanied ACE ACE2 angiotensin angiotensin (1-7) Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 association caused Cell cell surface circulation cleavage site COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathogenesis D614G D614G mutation decrease disease downregulate downregulated Effect expression fraction Free furin furin protease higher infectivity Hypothesis Imbalance in vivo infected cell infected cells Infection Inflammation investigated lack lead less lung Lungs membrane-bound murine model mutant natural infection Particle Pathogenesis pathogenesis of COVID-19 Prevalence Protein pulmonary damage receptor-binding domains Recombinant spike protein Renin renin-angiotensin system reported role S protein S1 and S2 S1 subunit S1 subunit shedding SARS-CoV virus SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 strain separation severity shown spike Spike protein subunits the cell the receptor-binding domain the S protein the S1 subunit the SARS-CoV-2 thrombosis trimer unlikely Viral Viral load virion virions wild type
[DOI] 10.1134/S0006297921030032 PMC 바로가기 [Article Type] Hypothesis

Loss of orf3b in the circulating SARS-CoV-2 strains

Research Article

Published on 2020-12-242022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, SARS,

[키워드] addition Alter amino acids analysed Analysis Betacoronavirus cause caused circulating Complete Continuous country COVID-19 pandemic D614G D614G substitution death ENhance Evolution France full-length functional Genome help human infection Laboratory Loss loss of function nine Non-synonymous notable ORF3a ORF3b prevalent Protein Q57H reached SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 strain SARS-CoV-2 strains Saudi Arabia South Korea stop codon Substitution the interferon Transmissibility Transmission USA viral adaptation viral genome viral pathogenesis viral strain virulence virus
[DOI] 10.1080/22221751.2020.1852892 PMC 바로가기 [Article Type] Research Article

An Overview of SARS-CoV-2 and Animal Infection

Veterinary Science

Published on 2020-12-112022-11-01
Journal: Frontiers in Veterinary Science [Category] COVID-19,

Multiple Introductions Followed by Ongoing Community Spread of SARS-CoV-2 at One of the Largest Metropolitan Areas of Northeast Brazil

브라질 북동부의 가장 큰 대도시 지역 중 하나에서 SARS-CoV-2의 지속적인 커뮤니티 확산에 따른 여러 번의 도입

Article

Published on 2020-12-092022-09-10
Journal: Viruses [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료기술,

Effects of Ozone Treatment on Personal Protective Equipment Contaminated with SARS-CoV-2

Article

Published on 2020-12-032022-10-28
Journal: The Cochrane database of systematic reviews [Category] COVID-19,

Conserved Genomic Terminals of SARS-CoV-2 as Coevolving Functional Elements and Potential Therapeutic Targets

공진화 기능 요소 및 잠재적 치료 표적으로서 SARS-CoV-2의 보존된 게놈 말단

Research Article

Published on 2020-11-252022-09-10
Journal: mSphere [Category] SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] 3′ untranslated region 3′-UTR acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis Animal coronaviruses antiviral drug antiviral drugs Betacoronavirus complex conserved contribute coronavirus coronavirus disease Coronavirus disease 2019 coronavirus genomes CoV COVID-19 death deaths disease disease outbreak Economy Effect effort element ENhance Evidence Factor feature function Genome H1N1 H1N1 virus Host Host immune response human host human microRNA identify Infection Infectious disease infectious disease outbreak Influenza influenza A Influenza A H1N1 influenza A virus Interaction investigated leads Lineage mechanism microRNA multiple group multiple groups Mutation outbreak pathogenicity phylogenetically Potential public health respiratory responsible SARS-CoV SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genome sequence SARS-CoV-2 pathogenesis SARS-CoV-2 replication SARS-CoV-2 strain sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarity survival target targets terminal the SARS-CoV-2 the SARS-CoV-2 genome therapeutic target therapeutic targets unique untranslated region Vaccine Variation Viral viral replication virus 3′ untranslated region weakened
[DOI] 10.1128/mSphere.00754-20 PMC 바로가기 [Article Type] Research Article

Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers, and convalescent plasma donors

COVID-19 환자, 의료 종사자 및 회복기 혈장 기증자의 SARS-CoV-2 급증에 대한 중화 항체

Technical Advance

Published on 2020-11-192022-09-12
Journal: JCI Insight [Category] SARS, 진단,

[키워드] antibody Antibody testing Cellular immune response cohorts convalescent plasma COVID-19 COVID-19 pathogenesis COVID-19 patients COVID-19 symptoms Donor donors Efficacy evaluate followed by glycoprotein HCWs Health care Health care worker health care workers highest highlight HIV-1 hospitalized patients human antibody response ICU ICU Patients individual individuals intensive care intensive care unit intron lentiviral lentivirus Neutralization assay neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Patient phenotypic phenotypic variation pseudotype pseudotyped Rapid reporter SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike SARS-CoV-2 strain secreted serological survey Serological surveys serum the SARS-CoV-2 Treatment Variation Virus neutralization was used
[DOI] 10.1172/jci.insight.143213 PMC 바로가기 [Article Type] Technical Advance

In Vitro Antiviral Activity of Doxycycline against SARS-CoV-2

Article

Published on 2020-10-312022-10-30
Journal: Molecules [Category] COVID-19, SARS,

[키워드] activities activity acute respiratory syndrome America Anti-inflammatory anti-inflammatory effect antimalarial Antiviral antiviral activity antiviral drug Antiviral effect approach approved drug Asia Clinical treatment clinically Co-infection Concentration containment measures coronavirus coronavirus disease COVID-19 doxycycline Drug discovery effective Europe evaluate experimental model expression high-risk patient identifying in vitro in vitro activity in vitro study initiated intravenous median moderate patients Prevent pro-inflammatory cytokine Prophylaxis Replication required SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 strain Severe COVID-19 Infection Spread Therapies translate Treatment Trial Vero E6 cell virus entry Wuhan, China
[DOI] 10.3390/molecules25215064 PMC 바로가기 [Article Type] Article

Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area

Research Article

Published on 2020-10-302022-10-29
Journal: mBio [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome Amino acid amino acid replacement amino acid replacements Analysis architecture Area caused Community coronavirus coronavirus disease COVID-19 COVID-19 disease CR3022 defined Diagnosis disease disease severity Evidence Evolution Features future infection generate Genome Genome sequencing genomic genomic data Genotype help host genetics Host immune response Houston Infection infections initial introduced Major massive Medical conditions molecular molecular population genomics monoclonal antibody nasopharynx Neutralizing pandemic Patient polymorphism produced provide Receptor binding domain Region SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 strain second second wave sequenced significantly higher Spike protein strain subsequent the SARS-CoV-2 the spike protein therapeutic trajectory Transmission Vaccine variant virulence virus virus genotype virus load Wave
[DOI] 10.1128/mBio.02707-20 PMC 바로가기 [Article Type] Research Article