Effect of ambient temperature on respiratory tract cells exposed to SARS-CoV-2 viral mimicking nanospheres-An experimental studySARS-CoV-2 바이러스 모방 나노스피어에 노출된 호흡기 세포에 대한 주변 온도의 영향-실험 연구Article Published on 2021-01-282022-09-12 Journal: Biointerphases [Category] 진단, [키워드] ACE-2 ACE-2 receptor acute respiratory syndrome airway epithelial cell ambient angiotensin-converting enzyme 2 binding bovine Calu-3 caused change coated with Community coronavirus country denaturing Effect fibroblast cell fluctuation had no Host host cell incubated indicated infect Infection Infectious disease Interaction lung epithelia mimicking modulated nonspecific Novel coronavirus occurred pandemic Polymer Protein RBD reached reported respiratory tract respiratory tract cell S protein S-RBD SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 viral seasonal serum Spread stability surface receptor temperature the S protein the SARS-CoV-2 Transmission Viral transmission virus [DOI] 10.1116/6.0000743 PMC 바로가기 [Article Type] Article
Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents잠재적인 항 SARS-CoV-2 제제로서의 3-키모트립신 유사 프로테아제(3CLPro) 억제제의 확인Article Published on 2021-01-202022-09-10 Journal: Communications Biology [Category] 신약개발, 치료제, [키워드] 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-SARS-CoV-2 boceprevir chymotrypsin Combination Coronavirus-2 develop drug drugs enzymatic activity enzyme enzyme activity exhibited FDA approved Drugs High-throughput screening homodimeric identification identify Infection inhibit inhibit SARS-CoV-2 inhibitor inhibitory activity inhibitory effect Ivermectin lack micafungin molecular molecular dynamics Molecular dynamics simulation morbidity ombitasvir outbreak paritaprevir protease public health Replication replication of SARS-CoV-2 respiratory SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral Screening selected severe acute respiratory syndrome Coronavirus simulation studies target targets the SARS-CoV-2 therapy tipranavir Viral was used [DOI] 10.1038/s42003-020-01577-x PMC 바로가기 [Article Type] Article
Genome Sequencing of Sewage Detects Regionally Prevalent SARS-CoV-2 Variants하수의 게놈 시퀀싱은 지역적으로 널리 퍼진 SARS-CoV-2 변이체를 감지합니다Research Article Published on 2021-01-192022-09-10 Journal: mBio [Category] 변종, 유전자 메커니즘, 치료기술, [키워드] abundance allele Area can be used characterized collected Complete Consensus coronavirus COVID-19 pandemic Environmental microbiology Epidemic epidemiological epidemiological surveillance Evidence generate genetic diversity Genome Genome sequencing genomes Genomics Genotype Local metagenomic metagenomics metatranscriptomic Nasopharyngeal swab nasopharyngeal swabs nucleotide Observed Patient Region RNA RT-qPCR San Francisco San Francisco Bay SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 viral sequenced Sequencing sewage Single nucleotide variant Spread Surveillance the United State United States utility variant Viral Viral genome sequencing viral lineage viral lineages viral spread viral strain viral strains wastewater [DOI] 10.1128/mBio.02703-20 PMC 바로가기 [Article Type] Research Article
DeepTracer for fast de novo cryo-EM protein structure modeling and special studies on CoV-related complexes530 Published on 2021-01-122022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] Accuracy Amino acid applied assist automated average cellular and molecular complex complexes Course Coverage cryo-EM de novo deep learning-based method determine disease drugs Efficiency electron explain High-resolution human cell information Interaction macromolecular macromolecule mechanism Microscopy modeling multichain Protein protein complex provide receptors residue robust SARS-CoV-2 viral sequence Significance Structure therapeutic Vaccine [DOI] 10.1073/pnas.2017525118 PMC 바로가기 [Article Type] 530
Tmprss2 specific miRNAs as promising regulators for SARS-CoV-2 entry checkpointArticle Published on 2021-01-082022-11-01 Journal: Virus research [Category] COVID-19, SARS, [키워드] Abstract Algorithms association binding Caco-2 Caco-2 cells cellular computer Coronaviruses COVID-19 differential expression experimental validation hsa-miR-214 hsa-miR-32 hsa-miR-98 humans identify in vitro Infection interactions Intervention management miRNA miRNAs molecular molecular target Pathogenesis Pathologies pool prevention of COVID-19 Probability Replication SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 viral selected therapy TMPRSS2 TMPRSS2 protein transcriptional regulator transfection Transmission utility [DOI] 10.1016/j.virusres.2020.198275 PMC 바로가기 [Article Type] Article
Proof of SARS-CoV-2 genomes in endomyocardial biopsy with latency after acute infection급성 감염 후 잠복기가 있는 심근내막 생검에서 SARS-CoV-2 게놈의 증거Case Reports Published on 2021-01-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] accompanied acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 cardiovascular cardiovascular complications causal relationship causative agent Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Endomyocardial biopsy Evidence Genome heart failure heart muscle Infection investigated latency Myocardial inflammation myocarditis pandemic Patient proof pulmonary symptoms reached reported respiratory SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus Symptom Viral viral infection viral myocarditis [DOI] 10.1016/j.ijid.2020.10.012 PMC 바로가기 [Article Type] Case Reports
Quantitative analysis of SARS-CoV-2 RNA from wastewater solids in communities with low COVID-19 incidence and prevalenceCOVID-19 발생률 및 유병률이 낮은 지역사회의 폐수 고형물에서 SARS-CoV-2 RNA의 정량 분석Article Published on 2021-01-012022-09-11 Journal: Water research [Category] SARS, 치료기술, [키워드] 16S rRNA 18S rRNA absence Analysis approach assays Bacteroide Bacteroides Biomarker Canada Capital Region city collected Community community infections Concentration conditions correlated COVID-19 COVID-19 incidence declining effective environmental conditions epidemiological fecal Frequency gene region Health health-care Human IMPROVE Infection less Metrics Mild MONITOR N1 and N2 National normalization normalized outcome Prevalence Prevent Primary clarified sludge public health Public health intervention Public health interventions quantification quantified reduce reducing resource RNA rRNA RT-qPCR sampling SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral SARS-CoV-2 viral RNA Sludge Solids Spread Surveillance Vaccine Viral virus wastewater water [DOI] 10.1016/j.watres.2020.116560 PMC 바로가기 [Article Type] Article
Hydroxychloroquine is associated with slower viral clearance in clinical COVID-19 patients with mild to moderate disease하이드록시클로로퀸은 경증에서 중등도 질환을 앓고 있는 임상 COVID-19 환자에서 더 느린 바이러스 제거와 관련이 있습니다.Article Published on 2020-12-242022-09-11 Journal: Medicine [Category] SARS, 치료제, [키워드] 24 hour 24 hours 95% confidence interval adjust antiviral drugs Comorbidities confounder COVID-19 COVID-19 patient Cox proportional hazard defined Efficacy Efficacy and safety followed by hazard ratio HCQ hospitalized patients Hydroxychloroquine Linear regression analysis Mild mild to moderate mild to moderate disease moderate disease Multiple multiple linear regression analysis multivariable nasopharyngeal Nasopharyngeal swab negativity oxygen Oxygen therapy Patient Pneumonia positive Primary outcome randomized clinical trial receive regression analysis RT-PCR assay SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral significantly Symptoms tested Treatment turn use of hydroxychloroquine Viral viral clearance was used [DOI] 10.1097/MD.0000000000023720 PMC 바로가기 [Article Type] Article
Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland Research Published on 2020-12-212022-10-05 Journal: Nature Microbiology [Category] SARS, 변종, 유전자 메커니즘, [키워드] absence acute respiratory syndrome Admission Analysis approach Community coronavirus Coronavirus disease 2019 COVID-19 COVID-19 case deaths diagnosed epidemiological Epidemiology Europe event Genome healthcare facility Hospital admissions identify Infection intensive care International introduced Italy majority measure Measures occurred outbreak Patient Phylogenetic population immunity quarantine reduced reveal risk SARS-CoV-2 SARS-CoV-2 viral Spain subsequent Transmission Travel [DOI] 10.1038/s41564-020-00838-z [Article Type] Research
Development of immunohistochemistry and in situ hybridisation for the detection of SARS-CoV and SARS-CoV-2 in formalin-fixed paraffin-embedded specimens포르말린 고정 파라핀 포매 표본에서 SARS-CoV 및 SARS-CoV-2 검출을 위한 면역조직화학 및 in situ hybridization 개발Article Published on 2020-12-142022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] addition against SARS-CoV animal animal models antibody Antigen antigen retrieval method applied causative agent caused coronavirus coronavirus pathogenesis COVID-19 demonstrated detect determine development dissemination evaluated expressing facilitate FFPE flexibility formalin formalin-fixed paraffin-embedded IHC immunohistochemistry infected cell infected cells Live virus MERS Microscopy non-infected cell non-infected cells nucleoprotein paraffin positive control probe protocol public health Research RNA SARS-CoV SARS-CoV spike protein SARS-CoV-2 SARS-CoV-2 viral specimen spike gene Spike protein tested therapeutic Therapeutics tissues utility Vaccine Viral virus virus detection [DOI] 10.1038/s41598-020-78949-0 PMC 바로가기 [Article Type] Article