The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patientsCOVID-19 환자의 임상 결과에 대한 흉부 CT 체성분 매개변수의 영향Observational Study Published on 2021-05-142022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 임상, 진단, [키워드] adipose Adipose tissue age baseline body composition C-reactive protein Chest CT Chest CT scans Clinical outcome COVID-19 patient COVID-19 patients CRP CT scan death died disease disease severity ectopic Effect extension fat accumulation female hospital Hospitalization Hospitalized Increased Inflammation lung mechanical ventilation median age mediation Mortality outcome outcomes oxygen oxygen saturation parameter parenchymal Patient patients performed Primary outcomes protective factor risk factor Risk factors secondary Secondary outcomes TAT tissue area vertebrae visceral with COVID-19 [DOI] 10.1371/journal.pone.0251768 PMC 바로가기 [Article Type] Observational Study
Randomized controlled trial of convalescent plasma therapy against standard therapy in patients with severe COVID-19 disease중증 COVID-19 질환 환자의 표준 요법에 대한 회복기 혈장 요법의 무작위 대조 시험Randomized Controlled Trial Published on 2021-05-112022-08-13 Journal: Scientific Reports [Category] SARS, 임상, 치료기술, 치료법, [키워드] 95% CI appear biochemical parameter Biochemical parameters clinical Clinical outcome confirmation Control Controlled trial convalescent patient Convalescent plasma therapy COVID-19 disease COVID-19 patient CP group died feasibility ferritin ferritin level higher risk hospitalized COVID-19 patient hospitalized COVID-19 patients hypoxia IMPROVE measure mechanical ventilation Mortality NIV no difference no differences no significant difference no significant differences Non-invasive not differ one patient open open label Patient pilot study plasma Primary outcome primary outcome measure Randomized Randomized controlled trials required respiratory indice respiratory indices risk risk ratio Safe secondary outcome secondary outcome measure Secondary outcomes severe COVID-19 severe COVID-19 disease severe disease Standard of care Standard therapy therapy Trial Two patient two patients Ventilation Virology [DOI] 10.1038/s41598-021-89444-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Study protocol for a phase II randomised, double-blind, placebo-controlled trial of perampanel as an antiepileptogenic treatment following acute stroke급성 뇌졸중 후 항간질 치료제로서 페람파넬에 대한 2상 무작위, 이중 맹검, 위약 대조 시험을 위한 연구 프로토콜Article Published on 2021-05-102022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 1:1 adverse event adverse events analysed approved baseline Cognitive function collected Concentration correlation cortical double-blind dysregulation Efficacy and safety enrolled epilepsy Ethics ethics committee evaluate Evidence Fisher Fisher's exact test Glutamate high risk HREC Human include ischaemic stroke life lobar magnetic resonance imaging Magnetic resonance spectroscopy matching placebo mechanism of action medication mood MRI outcome outcomes participant Patient perampanel performed Placebo placebo-controlled trial plasma Primary prevention proportion protocol Quality quantification Questionnaires randomisation randomised receive reference registration number Research Ethics scale secondary Secondary outcomes Seizure Seizures stratified stroke stroke medicine study period Support titration transfer Treatment unique Withdrawal [DOI] 10.1136/bmjopen-2020-043488 PMC 바로가기 [Article Type] Article
Standard Care Versus Awake Prone Position in Adult Nonintubated Patients With Acute Hypoxemic Respiratory Failure Secondary to COVID-19 Infection—A Multicenter Feasibility Randomized Controlled TrialCOVID-19 감염에 따른 급성 저산소성 호흡부전이 있는 성인 삽관되지 않은 성인 환자의 깨어 있는 자세와 깨어 있는 자세 비교 - 다기관 타당성 무작위 대조 시험Randomized Controlled Trial Published on 2021-05-052022-08-13 Journal: Journal of Intensive Care Medicine [Category] MERS, 임상, [키워드] 6 hour 6 hours acute hypoxic respiratory failure acute respiratory distress acute respiratory distress syndrome adverse events Awake prone positioning clinical trial conditions conducted Controlled COVID-19 COVID-19 pneumonia exceeded failure feasibility Feasibility study feasible group help hypoxia hypoxic respiratory failure knowledge maintain no significant difference non-intubated patient non-intubated patients observational studies observational study outcome oxygen pandemic parallel group Patient Pneumonia position Primary outcome prone prone group Prone position prone positioning proportion protocol Randomized rationale recruited requiring supplemental oxygen respiratory respiratory distress Respiratory failure Result Safe saturation secondary outcome Secondary outcomes secondary to significant difference Standard standard care supine supine group supplemental oxygen syndrome Trial with COVID-19 [DOI] 10.1177/08850666211014480 PMC 바로가기 [Article Type] Randomized Controlled Trial
Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial급성 COVID-19 호흡기 질환이 있는 성인을 위한 회복기 혈장(CONCOR-1): 국제, 다기관, 무작위 배정, 공개 시험을 위한 연구 프로토콜Study Protocol Published on 2021-05-042022-09-01 Journal: Trials [Category] SARS, 임상, 진단, 치료기술, 치료제, [키워드] acute COVID-19 acute respiratory syndrome Analysis anti-SARS-CoV-2 antibodies antibodies antibody titres baseline Blood Group CCP Community community acquired community acquired pneumonia CONCOR-1 convalescent plasma coronavirus COVID-19 COVID-19 infection criteria death detect detectable anti-SARS-CoV-2 antibodies detectable anti-SARS-CoV-2 antibody determine Donor donors Ebola Ebola virus Efficacy and safety estimation Evidence exclusion criteria Exploratory analyses global pandemic hospital include inclusion criteria independent Infection Influenza information intensive care interim analysis International Intubated intubation Middle East Middle East respiratory syndrome multicentre NCT04348656 Neutralization assay neutralization assays Non-intubated Novel coronavirus Open-label outcome oxygen Patient patients with SARS-CoV-2 plasma Pneumonia Primary outcome quantified randomization Randomized Randomized controlled trial randomized trial reaction receive receiving recruitment reduce reduction in Relative risk respiratory respiratory complication Respiratory complications Respiratory illness respiratory symptom respiratory symptoms responsible risk risk reduction Sample size SARS-CoV-2 SARS-CoV-2 antibody titre SARS-CoV-2 antibody titres SARS-COV-2 infection SARS-CoV-2 viral load secondary Secondary outcomes Serious Adverse Events Serologically Severe acute respiratory syndrome Standard of care Study protocol supplemental oxygen Support syndrome threshold thresholds titre transfusion reactions Trial two-sided Ventilator-free days Viral viral disease Viral diseases Viral load with COVID-19 [DOI] 10.1186/s13063-021-05235-3 PMC 바로가기 [Article Type] Study Protocol
Alterations in the lipid profile associate with a dysregulated inflammatory, prothrombotic, anti-fibrinolytic state and development of severe acute kidney injury in coronavirus disease 2019 (COVID-19): A study from Cincinnati, USA2019년 코로나바이러스 질병(COVID-19)에서 조절되지 않는 염증성, 혈전성, 항섬유소용해 상태 및 심각한 급성 신장 손상의 발달과 관련된 지질 프로필의 변화: 미국 신시내티의 연구Article Published on 2021-05-012022-09-11 Journal: Diabetes & metabolic syndrome [Category] SARS, 바이오마커, [키워드] Acute kidney injury ADAMTS13 AKI alteration analyzed Apolipoprotein Apolipoproteins association Biomarkers Cincinnati Control coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 cohort COVID-19 patient COVID-19 patients creatinine CRP decrease Department Deterioration dietetics disease driven by dysregulated Emergency emergency department Hospitalization Hypolipidemia ICU admission IL-10 IL-6 IL-8 immunothrombosis independent Inflammatory Inflammatory biomarker kidney LDL-C Lipid lipoprotein Lipoproteins multiorgan injury nutritional interventions observational study outcome Patient patients plasminogen Predictive presenting Primary outcome profile prospective observational study prothrombotic renal Secondary outcomes serum serum creatinine sick significantly lower thrombotic thrombotic microangiopathy USA were measured [DOI] 10.1016/j.dsx.2021.04.011 PMC 바로가기 [Article Type] Article
The impact of theory-based messages on COVID-19 vaccination intentions: a structured summary of a study protocol for a randomised controlled trial이론 기반 메시지가 COVID-19 백신 접종 의도에 미치는 영향: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-292022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 allocation approach automatically blinded Blinding comparator Contact contact with COVID-19 COVID-19 illness COVID-19 vaccination COVID-19 vaccine creating dissemination element ethnic group exposure to Follow-up Gender hypothesised illness beliefs Image individual individually randomised information initiate Intention Intervention investigator investigators messaging minute Necessity-Concerns Framework number objective online survey software outcome oversampling pandemic participant Participants performed post-intervention proportion Prospective protocol randomised randomised controlled trial receive reported Sample size secondary Secondary outcomes Side effect Side effects status Study protocol supplementary material treatment beliefs Trial Trial registration two group two groups Two-arm uptake vaccination vaccination against COVID-19 vaccination intention Vaccine vaccine for COVID-19 Vaccine hesitancy variable website [DOI] 10.1186/s13063-021-05277-7 PMC 바로가기 [Article Type] Letter
Assessment of Length and Readability of Informed Consent Documents for COVID-19 Vaccine TrialsCOVID-19 백신 시험에 대한 사전 동의 문서의 길이 및 가독성 평가Research Published on 2021-04-282022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 임상, [키워드] Accessibility Analysis analyzed assessment average CLARITY clinical trials collected complex complexity conducted Consent COVID-19 COVID-19 vaccine COVID-19 vaccine trial COVID-19 vaccine trials document effective enrolled examined exceeded explain finding Formal GRADE ideal Importance IMPROVE Informed Informed consent Length Level measure minute not difficult objective outcome participant Participants placebo group Point Quality improvement randomized clinical trial randomized clinical trials Readability reading receive reduce Relevance Research Research Ethics Result Safe score scored secondary Secondary outcomes setting the placebo group the vaccine Trial trials Vaccine [DOI] 10.1001/jamanetworkopen.2021.10843 PMC 바로가기 [Article Type] Research
A Systematic Review and Meta-Analysis of Cancer Patients Affected by a Novel CoronavirusMeta-Analysis Published on 2021-04-242022-10-31 Journal: JNCI Cancer Spectrum [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval affected association calculated Cancer cancer patient Cancer patients China Comorbidities coronavirus disease COVID-19 death disease driven by Fatality rate forest plot General population Hematological malignancy highest increased risk Interaction likelihood lung cancer Meta-analysis morbidity Mortality novel Older outcome Patient patients with COVID-19 proportion random-effects model reported Result review Secondary outcomes Subtypes survival systematic review therapy variables with COVID-19 [DOI] 10.1093/jncics/pkaa102 PMC 바로가기 [Article Type] Meta-Analysis
The effect of traditional Chinese medicine treatment for post-viral olfactory dysfunction A protocol for systematic review and meta-analysis바이러스 후 후각 기능 장애에 대한 한약 치료의 효과 체계적인 검토 및 메타 분석을 위한 프로토콜3800 Published on 2021-04-232022-08-31 Journal: Medicine [Category] Coronavirus, MERS, meta-analysis, SARS, [키워드] affected approval assist carried caused CBM China Chinese clinical assessments Clinical practice CNKI Controlled controlled trials COVID-19 data extraction database domain Effect effective Effectiveness Efficacy Efficacy and safety English ENhance Ethical approval Ethics evaluate evaluate the effect Evidence individual Infection Infrastructure journal life Meta-analysis network olfactory olfactory disorder olfactory disorders olfactory dysfunction Patient peer-reviewed performed post-viral Primary outcome PROSPERO protocol Quality of life questionnaire Questionnaires Randomized controlled trial Randomized controlled trials registration number reported respiratory respiratory viruses review secondary outcome Secondary outcomes subgroup analysis subjects systematic review TCM Traditional Chinese medicine Treatment VIP Visual Analogue Scale [DOI] 10.1097/MD.0000000000025536 PMC 바로가기 [Article Type] 3800